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The Janda Lab @LabJanda

Student run Twitter account for the lab of Prof. Kim Janda @ScrippsResearch. Follow for updates on current research in our group!

Joined July 2020
  • Tweets 24
  • Following 9
  • Followers 106
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Earlier this year we published our approach using a catalytic antibody to not only sequester carfentanil, but inactivate it. Ming will be presenting this paper along with other great work he has done at his defense in September! pubs.acs.org/doi/10.1021/acs…

Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression

Carfentanil, the most potent of the fentanyl analogues, is at the forefront of synthetic opioid-related deaths, second to fentanyl. Moreover, the administration of the opioid receptor antagonist...

pubs.acs.org
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Happy Friday from the Janda Lab 🍻 margaritas and pizza anyone?
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The Janda Lab retweeted
Anjali A. Sarkar, PhD@Anjali_Sarkar
1 Nov 2022
#Hybridoma screening, #pharmacokinetics and #pain tests enabled Kim Janda’s team at @scrippsresearch develop a monoclonal #antibody against #heroin in mice. genengnews.com/topics/drug-d…

Heroin Antibody Fares Better than Earlier Therapies That Targeted Its Metabolites

A monoclonal antibody against heroin (11D12) is effective in blocking the euphoric and lethal effects of this much-abused opioid. The current findings clarify the reasons underlying the failure of...

genengnews.com
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Our latest work showcasing a promising opioid immunopharmacotherapy and how it can help shift trends in vaccine development.
ACS Central Science@ACSCentSci
13 Oct 2022
NEW #ASAP Therapeutic monoclonal antibody for heroin abuse/overdose by @LabJanda shows vaccines have been mistargeting heroin’s metabolites for decades and should refocus efforts on heroin itself. Read here: go.acs.org/2tG
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Collaboration with Prof. Andrianov at the University of Maryland showed PCEP to be a promising adjuvant for anti-drug vaccines. When hapten design is already optimized, finding new adjuvants for intranasal immunization is the way to go. Check it out here: pubs.acs.org/doi/10.1021/acs…

Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development

Cocaine is a highly addictive drug that has seen a steady uptrend causing severe health problems worldwide. Currently, there are no approved therapeutics for treating cocaine use disorder; hence,...

pubs.acs.org
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Check out our latest paper: Identification of Slow-Binding Inhibitors of the Botulinum Neurotoxin Protease pubs.acs.org/doi/10.1021/acs… Congrats Ealin!

Identification of Slow-Binding Inhibitors of the BoNT/A Protease

Botulinum neurotoxin A (BoNT/A) is a lethal toxin, which causes botulism, and is categorized as a bioterrorism threat, which causes flaccid paralysis and death. Botulinum A neurotoxicity is governed...

pubs.acs.org
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Our most recent publication in JMC: A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl pubs.acs.org/doi/10.1021/acs… Congrats Jinny and Hyeri!

A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than...

New psychoactive substance (NPS) opioids have proliferated within the international drug market. While synthetic opioids are traditionally composed of fentanyl analogues, benzimidazole-derived...

pubs.acs.org
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During National Immunization Awareness Month (August 2021), we congratulate Dr. Kim D Janda of Scripps Clinic and Research Institute -- Recognized as an Expertscape Expert in Synthetic Vaccines. expertscape.com/ex/vaccines%…
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Our lab recently published a potential therapeutic for the synthetic cannabinoid PB-22. Congrats Ming! pubs.acs.org/doi/10.1021/acs…

Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22

Synthetic cannabinoids are part of a group of drugs called new psychoactive substances. Most of these cannabinoids are unregulated, and there are no therapeutic treatments for their addictive...

pubs.acs.org
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Salicylanilides as a promising therapeutic for COVID-19? Check out our latest paper to read more about it! pubs.acs.org/doi/10.1021/acs…

Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a...

SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highly contagious, to dying from acute respiratory distress...

pubs.acs.org
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Check out a synthetic fluorescent MYC probe we found and how we developed a high-throughput screening assay that found a promising lead compound. sciencedirect.com/science/ar…
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A new paper from our lab is out on Chemrxiv that used structure-based drug design as a way to develop inhibitors of botulinum neurotoxin A protease. Congrats @LewisTu52514415 and @alexanderln91! doi.org/10.26434/chemrxiv.14…

Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A...

We have used crystal structures and molecular modeling to evaluate inhibitor binding modes and design a series of compounds to take advantage of a new, cryptic, hydrophobic sub-pocket. This is a...

chemrxiv.org
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Our recent publication on irreversible bifunctional inhibitors of botulinum neurotoxin A is out in RSC Med Chem, check it out! Congrats @LewisTu52514415 and @alexanderln91 🥳 pubs.rsc.org/en/content/arti…

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Here is our original proof of concept for this recent publication! pubs.acs.org/doi/10.1021/acs…

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two...

pubs.acs.org
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Check out our latest work on an improved dual hapten vaccine for fentanyl-contaminated heroin! sciencedirect.com/science/ar…
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Congrats to Lisa on the paper published today on two synthetic opioid vaccines! It not only elicits high-affinity antibodies against carfentanil and fentanyl, but also offers protection against opioid-induced respiratory depression. pubs.acs.org/doi/10.1021/acs…

A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory...

The opioid epidemic remains a dire public health crisis with millions of people currently suffering from opioid use disorder (OUD) and tens of thousands dying each year. Synthetic opioids are most...

pubs.acs.org
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We're excited to share our latest work on the first broadly neutralizing vaccine for synthetic cannabinoids in JACS Au! pubs.acs.org/doi/10.1021/jac…

Broadly Neutralizing Synthetic Cannabinoid Vaccines

Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming a major public health risk. Due to the wide variety of SCs, broadly neutralizing antibodies generated...

pubs.acs.org
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Happy to share our latest work on bifunctional covalent inhibitors of Botulinum Neurotoxin in JMedChem! pubs.acs.org/doi/10.1021/acs…

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two...

pubs.acs.org
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We are features in the latest issue of Newsweek.
Scripps Research
@scrippsresearch
13 Aug 2020
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how-…
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The Janda Lab retweeted
Scripps Research
@scrippsresearch
13 Aug 2020
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how-…
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