Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology
Joined June 2019
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49 Photos and videos
Anthony Rullo: chemically modulating proximity retweeted
Jun 11
Multi-equilibria systems offer a highly regulated control over pathway selection & switching.
End-result: chemical platform to discover new reactions, targets, and opportunities
Credit @RAJIB__MOLLA, @Dwaipayan_13, and team at @chm_iiserb, @iiserbhopal
cell.com/cell-reports-physic…
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Anthony Rullo: chemically modulating proximity retweeted
Triazenyl Furans as Diels–Alder Dienes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Linker-Driven Sampling of PROTAC-Induced Ternary Complexes | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…
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Anthony Rullo: chemically modulating proximity retweeted
A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference
nature.com/articles/s41589-0…
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Anthony Rullo: chemically modulating proximity retweeted
May 1
It‘s time to remove the question mark!
A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc.
1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!
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Anthony Rullo: chemically modulating proximity retweeted
Apr 16
Fast and Selective Labeling of Serine and Threonine in HFIP for Facile Editing of Peptide Alcohol Side Chains | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Apr 6
Just out @J_A_C_S Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation
pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation | ACS Chemical Biology pubs.acs.org/doi/10.1021/acs…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 31
Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation | Bioconjugate Chemistry pubs.acs.org/doi/10.1021/acs…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 22
Discovery of Covalent Ligands with AlphaFold3 | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 20
Confinement Catalysis Enables Macrocyclization at Up to 0.6 M: Selective Formation of Mono- and Dimeric Glycosidic Macrocycles | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 18
Beyond traditional strain-promoted azide–alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides
Nature Communications 2026
nature.com/articles/s42004-0…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 18
Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
Mar 16
AI‐Based Prediction of PROTAC‐ and Molecular Glue‐Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz‐2 - Riepenhausen - 2026 - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/…
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Anthony Rullo: chemically modulating proximity retweeted
A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors go.nature.com/4uC0qiM
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Anthony Rullo: chemically modulating proximity retweeted
Mar 6
Nature holds the keys to PPIs—why don't we use them? Some thoughts on stabilizing hotspots without sequence changes, using the emerging non-symmetric stapling. This could unlock the therapeutic potential of native peptides. Now out as @ChemRxiv preprint. chemrxiv.org/doi/full/10.264…
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Farewell to a giant in chemical immunology and induced proximity
Mar 6
Today I lost a dear friend, mentor, and colleague. Dr. Philip Low was a brilliant scientist whose discoveries transformed human health. I’m deeply saddened by Phil’s passing and grateful for his friendship and mentorship. His legacy will endure. purdue.edu/newsroom/2026/Q1/…
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Anthony Rullo: chemically modulating proximity retweeted
Tetrazine-Mediated Bioorthogonally Activated Therapeutic (TBAT) Platforms | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Anthony Rullo: chemically modulating proximity retweeted
A @nchembio study led by Assoc. Prof. @Michael_A_Erb describes a strategy to deliberately discover “molecular glue” degraders by converting existing protein binders into compounds that recruit the cell’s disposal machinery, selectively degrading ENL and BRD4. More: ow.ly/Fqrr50YoenT
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Anthony Rullo: chemically modulating proximity retweeted
Awesome new @biorxivpreprint from @Keribackus and Amit Choudhary @harvardmed. A modular platform for #proximity #pharmacology. Converting known inhibitors into PTM writer/erasers, using endogenous proteins, tunable Lys/Cys-targeting chemistry. Great read! biorxiv.org/content/10.64898…
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