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Spiegelman Lab @LabSpiegelman

We study metabolic pathways regulating energy homeostasis, mitochondrial biogenesis, and muscle/adipose biology @DanaFarber @HarvardCellBio

Joined May 2021
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Spiegelman Lab@LabSpiegelman
Apr 3
When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. nature.com/articles/s42255-0…

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells

Nature Metabolism - This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local...

nature.com
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Another great annual retreat goes in the books. Our rule is you cant talk about what you work on, and it was so interesting. Props to the lab techs who each gave a great talk. Rockport is so lovely in the spring!
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Spiegelman Lab retweeted
Nature Metabolism
@NatMetabolism
May 21
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis dlvr.it/TSfYKP

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

Nature Metabolism - Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral...

nature.com
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It is interesting to note, that much of the effects of irisin can be ascribed to the subsequent production of IL-33 by stromal cells within the adipose tissues. We never imagined such a mechanism in 2012! Big congrats to Mu and Gang for these determined efforts.
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Lab alums Hage Sprenger and Louisa Grauvogel cut loose at Karneval in Köln!!
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Last day of fishing is such a bittersweet day!
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Beware of scary scientists on Halloween!
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Sumeet Khetarpal@SumeetKhetarpal
27 Sep 2025
Here is @Rongtian2's News & Views article: nature.com/articles/s44161-0… @LabSpiegelman @rosenzweig_a
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Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) nature.com/articles/s44161-0…

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The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mang…
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Davo was a fantastic cook. This is after our last fishing adventure is June 2025
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It's not true that Jared Rutter can only do metabolite signaling! @CapeCod Bay
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Matt Gilbert and Krys Seremak cartooning the boss's favorite saying at lab meetings 🤣
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Spiegelman Lab retweeted
Harvard University
@Harvard
23 May 2025
Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t

Supporting Our International Students and Scholars

We have just filed a complaint and a motion for a temporary restraining order will follow. As we pursue legal remedies, we will do everything in our power to support our students and scholars.

harvard.edu
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Another great Spiegelman Lab Retreat goes in the record books. Everybody gives a talk, but it can't be what you work on! Stretch the mind.
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What a great occasion! Our Visiting Student Alex Braunsperger and Paulina Braunsperger-Wasserfurth tie the knot, Bavarian style. Heartly Congrats!
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A new discovery from the bowels of the DFCI CB business office. I'm gonna say Jae Bum Kim and Peter Sellers from The Pink Panther movie?
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Team Adipose Inflammation meets up again! @gshlab
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Yay Shingo! • Shingo Kajimura, PhD is the recipient of the 2025 Outstanding Scientific Achievement Award of the ADA, which recognizes research in diabetes that demonstrates particular independence of thought and originality. @KajimuraLab
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Ergothioneine is an atypical amino acid to which many health benefits in humans have been ascribed. Here we determine the direct protein target of ergo binding and how it functions in mitochondria and exercise. authors.elsevier.com/c/1kdIa…

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Hage Sprenger is back in Koeln, Germany starting his own lab. Check him out at @hagesprenger.bsky.social
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