Taking a first step towards hibernation pods :)  Just announced a $58M Series A led by @foundersfund to back the core roadmap reversibly cryopreserve human organs -> help transplant patients build sustainable business -> accelerate R&D for whole body cryo

curious if there are any examples, anywhere in biology, of cells 'throwing' a molecule from one point to another (ie the trajectory direction of velocity of the non-tethered molecule matter, functionally - not just magnitude)

Hello! I'd like to host a small 'let's understand Galois / group theory' meetup in SF. If you've ever spent hours staring at group theory textbook desperately trying to understand why it's relevant to polynomials - this meetup is for you! luma.com/8dy5h2a4

first FDA approval resulting from a company in the portfolio! so so excited for all those involved the patients who now have access to a transformative therapy ❤️

!! wow congrats to the team! it's very cool to see this kind of result (doubling median survival 6.7 mo -> 13.2 mo), esp for metastatic pancreatic cancer (notoriously difficult prognosis)

:)

very excited for this!

aw!

Random molecule thoughts from today: - I'm a water molecule in the cell. Am I warm or cold? Oh wait! I don't have temperature (too small, just feels like velocity / being bumped into by other fighter jets running at the speed of sound - ouch!) - feels mildly dehumanizing, but then again, I am a water molecules >.< - Tiny molecules like H20 are SO much smaller than proteins, I actually had the incorrect intuition here - ~0.3nm vs ~20-30 nm for very large protein complexes (like ribosomes) - so ~100x my human size for comparison. This is like a Statue of Liberty, or a sequoia! - One thing the H20/protein size intuition updated me on is the amount of time a molecule of that size might have to spend 'searching' the surface of the protein (ie NO in a relevant signaling context). I think I don't understand this well enough (not obvious how much ie NO signaling is limited by this given the way / speed at which it diffuses), but it was cool to at least generate a curiosity-inducing intuition from a simple thought expt! (also, while the ChatGPT-generated image is cute and funny, I should note that molecules do not have eyes...but I do think coloring molecules while doing visual thought expts is reasonable)

I'm curious what the equivalent of the qualia of love will be in ~100 years (surprising, emergent property) - it feels (to me) like something I could never have predicted if I were 'guessing how single cell life would unfold'.

I want to host a small, ~5 person, 'simple questions for biology' hangout this Saturday, at 1:30p Come if you are a beginner / visual thinker, are willing to do an hour of somewhat guided self study, and want to learn one cool thing about biology! RSVP here (if it fills up and adds you to a waitlist, I'll let you know about future sessions if I do them): luma.com/2ft62qxw more info: the format: we go to a park, and talk/teach each other about biology! my goal will be for you to leave having learned at least one cool biology fact, but trying out this format so no guarantees. come prepared to do active learning / not just be lectured at! please come if you are: a beginner (no biology experience required!), interested in biology but not yet knowledgeable, especially if you play a lot of videogames and are a visual/spatial thinker!

reversible cryo is one of the most important and beautiful ideas I've ever met wrote a primer about it for the curious! might go through another draft so feedback welcome :) notebook.ldeming.com/whyilov…

maybe an odd q, but is there a comprehensive list of mental representation structures? would love any recs!

thanks for having us! getting to chat science with @jacobkimmel was super fun, and I really appreciated the thoughtful questions