Seeing new things by using fluorescent proteins and interesting microscopes
Joined December 2020
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34 Photos and videos
Apr 14
I took my hand (specifically, my hurting middle finger) to the doctor today... Here is the result😇. They made me do it😂. Less fun: if you look closely, you will see that the end of the bone is crushed🙄
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Apr 13
Unrelated: last week I gave a seminar for the students of the Science program of Charles University (natur.cuni.cz/uchazeci/studi…). Seems like an excellent program and a lovely group of students!👍😍 I hope they enjoyed it as much as I did!
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Apr 13
Got my hand pinched by a door a week ago... Ouch! 😰 One of my fingers still hurts, but Petro has now at least made it look better... At least in Photoshop🙂
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Feb 22
The actual video can be watched here... We are on at time 6:29
ct24.ceskatelevize.cz/rubrik…
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Jan 19
Check out how this translocation-based biosensor develops linear dichroism (when the orientational freedom of the fluorescent protein becomes restricted)! 😎 Imaged with our new, super-fast confocal LD microscope🔬⚡️, now available from innovativebioimaging.com
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Jan 18
We used a super-fast linear dichroism confocal microscope based developed in collaboration with our friends at KU Leuven:
The TriScan: fast and sensitive 3D confocal fluorescence imaging using a simple optical design biorxiv.org/content/10.1101/…
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Jan 18
Microscopy imaging of activation of the b2-adrenergic receptor by using a FLIP biosensor - resting state (on the left) and after b2AR activation (on the right). Can you spot the difference?🤔 Pretty cool, huh? 😎🙂
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Jan 18
FLIPs are new, super-simple molecular biosensors that convert molecular events into changes in orientation of a fluorescent protein. This change is then observable by linear dichroism (LD) microscopy. Isn't this simple?
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Jan 18
And this is the paper we were celebrating!🥂:
FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy | Science Advances science.org/doi/10.1126/scia…
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Jan 16
We had a little celebration of our upcoming paper in Science Advances... One of the co-authors showed up in full strength!💪😱 Keep up the good work, Alex!😂
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20 Nov 2025
Electronics is fun! I did some microscopic soldering for the first time today...🔬😎 It worked!💪🏼
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10 Sep 2025
We see that an intrabody based on NB32 distinguishes between different GPCR conformations. This can be used in biosensors based on bioluminescence, but also in fluorescent biosensors that utilize linear dichroism/polarization microscopy🔬. Check it out!
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10 Sep 2025
After many, many days and nights of work, our joint paper with the Shukla lab (@arshukla) is out:
pnas.org/doi/10.1073/pnas.25…
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4 Aug 2025
A joint manuscript with @arshukla accepted, with Vendy Nagy Marková as a first co-author! Thank you, Arun & al.! Btw., first submission: 1.5 years ago 😂
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29 Aug 2024
Got back from the EMC meeting in Copenhagen @eurmicsoc #EMC2024... Impressive results by
@CizmarTomas, and a well-deserved prize, for imaging through an optical fiber🙎♂️🧵🔎🎥🖼️!
Also impressive: the Copenhagen airport security!👮😉
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25 Aug 2024
Finally: we are now revising our joint paper with Arun Shukla (@arshukla) on cool conformation biosensors of arrestin signaling:
biorxiv.org/content/10.1101/…
Looking forward to getting it published!
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25 Aug 2024
I think it turned out to be a fun event both for the adults and for the younger participants!👦👧 Thank you, Vendy, for hosting it!
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25 Aug 2024
Speaking of the lab retreat: some scientists could definitely use more sun ☀️ :-)
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