Bon courage

🍫 TABLEAU FINAL DES PRESQUE-MÉDAILLES 🏅 ON PENSAIT QUE C'ÉTAIT IMPOSSIBLE MAIS ILS L'ONT FAIT. QUATRIÈME DES QUATRIÈMES. CHEZ NOUS, DANS NOS JEUX. LE CHOCOLAT LE PLUS PUR.

Variants in type 1 and type 3 von Willebrand disease occur throughout the gene, whereas variants associated with type 2 VWD are localized to specific VWF domains. go.nature.com/4cSDuCA

This Figure shows an algorithm for diagnosis and subtyping of von Willebrand disease. go.nature.com/4cSDuCA

von Willebrand factor is essential in recruiting platelets to sites of vascular injury; in intact blood vessels with normal flow conditions, this function is inhibited by bound procoagulant factor VIII. #VWD go.nature.com/4cSDuCA

von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD go.nature.com/4cSDuCA

Paving the way to factor X deficiency therapies ow.ly/rAf750SzQnB #thrombosisandhemostasis

Fitusiran is an investigational siRNA reducing antithrombin expression that is under clinical evaluation for the treatment of hemophilia. ow.ly/iax450SzP4M #thrombosisandhemostasis

Great job Geneviève 💪💪👏👏

C’est super Jean!! Bravo !!!

In the 1800s, Scottish surgeon Robert Liston became infamous for a surgery that led to an astonishing 300% mortality rate, losing his patient to infection, accidentally amputating his assistant's fingers, who also died of infection, and slashing a spectator who died from heart attack. While amputating another patient's leg, he broke his personal record by finishing the surgery in two and a half minutes. However, in the interest of speed, he chopped off the patient's testicles along with his leg. He also once mistook a lump in a young boy's neck for a skin tag and removed it suddenly at the boys home. The lump turned out to be an aneurysm of his carotid artery, and the boy died. Keep in mind that in those times there was no anesthesia and that speed and cleanliness were the only skills. Known as "the fastest knife on West End," Robert Liston was particularly skilled at quick amputations. Where most surgeons at that time lost one in four patients, due to his speed and skill, Liston only lost about one in ten.

Congratulations to Geneviève McCluskey and Rodrigo Núñez-Cortés for winning the Christine Lee Young Researcher Award best oral and best poster respectively! #WFHCongress2024

A huge congrats to Dr Genevieve McCluskey for her work on Fitusiran in FX deficiency 👏👏 #wfhCongress2024 @InsermU1176

#WFHCongress2024 Attending a "Free paper session" by young female researchers from three different continents. Inspired by the diversity and talent in science! #WomenInScience #FemaleResearch #hemophilia

All 4 young investigators did a great presentation !!

Dr Geneviève McCluskey giving a great presentation on her work on repurposing fitusiran for Factor X-deficiency.

C'est un honneur pour toute notre équipe à l'Institut Coeur Poumon de collaborer avec l'équipe du Pr Messas pour évaluer cette thérapeutique innovante et non-invasive pour traiter les patients qui souffrent de sténose aortique mais qui ne peuvent pas être opérés.

Did you know it’s von Willebrand Disease Awareness Day? VWD is the most common bleeding disorder, affecting ca. 1% of the population. Our VWD360 study is exploring its impact on individuals and families. Access our survey here: bit.ly/42jpzAZ #VWDunited #beVWDaware

On von Willebrand disorder awareness day, we celebrate the incredible work being done to further improve treatment and diagnosis. Their dedication, passion and determination is truly inspiring. #vonwillebranddisorder #VWDAwareness #VWDAwarenessDay

EHC VWD Committee members about European VWD Awareness Day! Join us to raise global awareness! #VWDunited #beVWDaware #VWDtogethere