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Joined July 2019
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100 Photos and videos
Our new study online today @MolNeuro shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes link.springer.com/article/10…
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Our new JCI review discusses the cGAS-STING pathway's evolution & molecular roles beyond inflammation & highlights how activation affects glial states, neuronal homeostasis, & BBB integrity, yielding new therapeutic paths in neurodegenerative disease pubmed.ncbi.nlm.nih.gov/4222…
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Lu et al. profiled >10,000 plasma & CSF samples to uncover how APOE2 & APOE4 confer divergent AD risk. APOE2 protects by sustaining homeostatic & anti-inflammatory signatures before Aβ accumulation, whereas APOE4 proteomic changes respond after pathology nature.com/articles/s43587-0…
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In our latest preprint, we show microglia protect against levodopa-induced dyskinesia (LID): microglia-derived sTREM2 acts on TrkB, boosts BDNF-TrkB signaling, and points to plasticity as a potential Parkinson’s/LID therapy biorxiv.org/content/10.64898…
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Excited to share our spotlight article in Cell Stem Cell on CAR-A astrocyte therapy for Alzheimer’s disease, an innovative approach for in vivo amyloid clearance. We discuss both the promise and the challenges ahead. 🧠
sciencedirect.com/science/ar…
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New in Nature: de Faria et al. show focal white matter lesions trigger remote microglial response to demyelinated neurons in grey matter, which is required for remyelination. Deplete grey matter microglia→repair failures→chronic grey matter inflammation doi.org/10.1038/s41586-026-1…
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New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s41591-0…
ALT Snapshot of Fig 1 from Nat Med paper
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Check out our earlier work: Immunotherapy targeting AcTau174 improves cognition in mouse models of TBI & tauopathy, establishing AcTau174 as a driver of cognitive decline link.springer.com/article/10…
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Paquet lab addresses iPSC limitation: new line with endogenous P301L/S320F 4R tau develops age-related tauopathy phenotypes stem cells typically fail to model. Platform shows pathological tau aggregation for more precise tauopathy research & drug screening
science.org/doi/10.1126/scit…
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MAPT p.R406W disrupts autophagy–lysosome pathway, impairing Tau degradation. Mutant neurons accumulate Tau/pTau in lysosomes, impairing motility, fusion, & clearance. Autophagy enhancement lowers Tau & restores degradation but doesn't rescue trafficking nature.com/articles/s41467-0…
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The 13th Annual Appel Symposium on Mar 24 spotlighted the interconnectedness of neurodegenerative diseases. Drs. Sreeganga Chandra (Yale), Eddie Lee (UPenn), & Anna Orr (Appel) gave keynote presentations, preceded by over two dozen trainee posters from Appel & collaborating labs
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