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Life Medicine @LifeMedJournal

Life Medicine is a fully open access, peer-reviewed journal that aims to accelerate the translation of life science research from bench to bedside.

Joined August 2021
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Identification of deferasirox as a human xanthine oxidase inhibitor doi.org/10.1093/lifemedi/lna…

Identification of deferasirox as a human xanthine oxidase inhibitor

The incidence of hyperuricemia, characterized by elevated serum uric acid (UA) concentration in extracellular fluid and tissues or impaired UA excretion, i

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Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling doi.org/10.1093/lifemedi/lna…

Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling

Abstract. Cellular senescence is a key contributor to aging and aging-related diseases, but its metabolic profiles are not well understood. Here, we perfor

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Proteomic aging atlas identifies senoproteins as drivers of vascular and systemic senescence doi.org/10.1093/lifemedi/lna…

Proteomic aging atlas identifies senoproteins as drivers of vascular and systemic senescence

Mammalian aging is a natural process marked by the progressive decline of organ function and increased vulnerability to chronic diseases. Organs follow dis

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iPSC-derived breast cancer models: advancing the study of BRCA1-driven tumorigenesis doi.org/10.1093/lifemedi/lna…

iPSC-derived breast cancer models: advancing the study of BRCA1-driven tumorigenesis

The advent of induced pluripotent stem cells (iPSCs) has created a powerful platform for building human disease models. Since Yamanaka’s pioneering demonst

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Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes doi.org/10.1093/lifemedi/lna…

Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes

Abstract. Rosacea, as a progressive and chronic inflammatory skin disease, lacks safe and effective treatment options. Our previous study reported metaboli

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Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development doi.org/10.1093/lifemedi/lna…

Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development

Abstract. Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological propertie

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Natural compounds of medicinal plants as a source for novel anti-orthopoxvirus medications doi.org/10.1093/lifemedi/lna…

Natural compounds of medicinal plants as a source for novel anti-orthopoxvirus medications

Natural products are increasingly recognized as promising sources of antiviral agents against Mpox. Current in silico and in vitro findings point to severa

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HDAC8-selective inhibitor PCI-34051 protects against aortic dissection by attenuating ferroptosis of vascular smooth muscle cells doi.org/10.1093/lifemedi/lna…

HDAC8-selective inhibitor PCI-34051 protects against aortic dissection by attenuating ferroptosis...

Abstract. Aortic dissection (AD) is a fatal emergency which lacks effective drug therapies. Previous studies demonstrated that histone deacetylase 8 (HDAC8

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Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets doi.org/10.1093/lifemedi/lna…

Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and...

Abstract. Integrated genomic evidence on shared genetic architecture between obesity and psychiatric disorders remains limited. This work utilized multi-le

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Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications doi.org/10.1093/lifemedi/lna…

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiati...

Abstract. Cell-based immunotherapy, recognized as living drugs, is revolutionizing clinical treatment to advanced cancer and shaping the landscape of biome

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A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement doi.org/10.1093/lifemedi/lna…

A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

Abstract. Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural e

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Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling doi.org/10.1093/lifemedi/lna…

Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via...

Abstract. The decline in intestinal stem cell (ISC) function is a hallmark of aging, contributing to compromised intestinal regeneration and increased inci

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Oral microbiota in aging and diseases doi.org/10.1093/lifemedi/lna…

Oral microbiota in aging and diseases

Abstract. Human microbiomes are microbial populations that form a symbiotic relationship with humans. There are up to 1000 species on the surface of human

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Versatile platelets contribute to rejuvenation doi.org/10.1093/lifemedi/lna…

Versatile platelets contribute to rejuvenation

Aging is manifested by the progressive deterioration of tissues and organs, with associated changes in cellular composition, transcriptional programs, epig

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CD157 selectively identifies hPSCs with enhanced hepatic differentiation capacity doi.org/10.1093/lifemedi/lna…

CD157 selectively identifies hPSCs with enhanced hepatic differentiation capacity

Dear Editor,

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Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis doi.org/10.1093/lifemedi/lna…

Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis

Dear Editor,

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The complex landscape of immune dysregulation in multisystem inflammatory syndrome in children with COVID-19 doi.org/10.1093/lifemedi/lna…

The complex landscape of immune dysregulation in multisystem inflammatory syndrome in children with...

Abstract. The immune responses following SARS-CoV-2 infection in children are still under investigation. While coronavirus disease 2019 (COVID-19) is usual

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mRNA therapy: a precise and efficient approach for disease treatment doi.org/10.1093/lifemedi/lna…

mRNA therapy: a precise and efficient approach for disease treatment

The field of messenger RNA (mRNA) therapeutics is currently at the forefront of medical research, with numerous clinical trials actively exploring its pote

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Xenotransplantation: How close are we to clinical applications? doi.org/10.1093/lifemedi/lna…

Xenotransplantation: How close are we to clinical applications?

Xenotransplantation has recently made the leap from large animal models to preclinical and clinical research. In the USA, several preclinical studies have

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The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans doi.org/10.1093/lifemedi/lna…

The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility...

Abstract. The ovary plays a crucial role in the reproductive system of female mammals by producing mature oocytes through folliculogenesis. Non-human model

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