Thrilled to share our @CellCellPress paper with Shosei Yoshida & Ben Simons, led by @ChakraArun: 1) spatial geometry can resolve temporal dynamics 2) Sertoli cells run an intrinsic cycle coupled to germline, suggesting oscillator coupling as a principle of tissue organization

Just posted a preprint on our new spatial genomic recording system, baseMEMOIR. biorxiv.org/content/10.1101/… Motivation: Cells divide, differentiate, and migrate to form exquisitely organized tissues. Reconstructing the dynamic histories of individual cells, including their lineage relationships and ancestral states, is essential for understanding how intrinsic and extrinsic signals generate tissues during development and in regenerative medicine. Engineered genomic recording systems can reconstruct cell lineage histories from endpoint measurements. However, existing methods either require sequencing (disrupting spatial organization) or have been limited in memory size and scalability. To address this need, @ChadlyDuncan, Kirsten Frieda, and others in the lab created a high memory capacity image-readable recording system termed baseMEMOIR.

Check out Giotto Suite — our latest tool for spatial multiomics analysis. This is a complete overhaul of the original Giotto package, a result from years of making. Great collaboration with @RnDries team. Kudos to @jiaji_g_chen @josschavezf1 and the entire Giotto team!