We've released a new summary of the purpose of the first Robust Mouse Rejuvenation study, the conclusions we've been able to draw so far, and what needs to happen to unlock the full meaning of the data sets. Check it out: levf.org/breaking-the-ceilin…

LEVF's RAID (Rodent Aging Interventions Database) project aims to record and compare all publications documenting successful lifespan extension in strains of rodents (mice and rats) with normal baseline lifespans. In this new video our Chief Science Monitor, Maximus Peto, walks us through the scope and features of the web tool we designed to enable easy visual exploration of RAID's content.

levf.org/october-2024-matchi… Longevity Escape Velocity Foundation (LEVF) today welcomes two very generous donations from long-time supporter of longevity research and activism, Didier Coeurnelle. The first donation is 200,000 euros (approximately 220,000 US dollars). The second donation, of up to another 200,000 euros, is dependent on LEVF receiving matching gifts from other donors from 1st October until the end of the month (October 31st). These donations enable a key set of pre-study pilots ahead of the next phase of LEVF’s groundbreaking investigations into the effects of combining different damage-repair interventions for middle-aged mice.

Here's RMR1 update #14! The survival curves continue to provide tantalising but preliminary information. Particularly exciting is how long the all-control group took, measured from the start of the study, to reach the survival percentage that the all-treatment group is currently at (namely 45% for females and 65% for males): we can look at the ratio of the two in order to ask how well the combination is working. As of now, for females it's (973-578)/(816-578) = 1.66, and for males it's (973-578)/(841-578) = 1.50. (See the dotted lines that I've added to the graphs.) So that's not the effect size that I've defined as "robust mouse rejuvenation", which is a ratio of 2, but it's a good deal better than any other study I know of. The message - and again, I know it's only preliminary - is that RMR1 is confirming the two fundamental beliefs that motivate this research program: first, that combo rejuvenation has greater potential than any other longevity approach, and second, that it's hugely important to do more of these studies, starting with the one whose design we announced a few months ago (see levf.org/rmr2). We are still struggling to raise the funds for that study; I'm devoutly hoping that the ongoing success of RMR1 will change that soon.

The full text of our first peer-reviewed paper, evaluating the field's progress towards rejuvenation therapies and highlighting the particular importance of combination studies, is now available to read free of charge: tandfonline.com/doi/full/10.…

Our prep for the Robust Mouse Rejuvenation program included a survey of past efforts to extend rodent lives. We're making that data available to the community as RAID, a visual comparison of the success achieved by different interventions. Take a look! levf.org/raid

Latest RMR update, sa screenshots from FB as ever:

RMR update #11! Screenshots from FB as ever.

LEV Foundation's Chief Science Monitor, Maximus Peto, is writing a new series of articles exploring the rationale behind the interventions chosen for the first Robust Mouse Rejuvenation study. The first essay - on senolytics - is available to read now. levf.org/articles/the-case-f…

Everyone who contributed $100 or more to our End-of-Year fundraiser has now been sent a form to select your donor reward. If you haven't seen that message, please check your spam/junk folder, and get in touch if needed - rewards must be claimed by the end of January!

We're hugely grateful to everyone who contributed to our 2023 EOY Fundraiser; the whopping $322,760 you donated will enable us to build on the Dublin Longevity Declaration's success, continue developing the second RMR study, and much more (t.ly/OZnx3). Thank you!🙏

There's just one day left to make a contribution to our End-of-Year fundraiser, and earn yourself a donor reward! Just $100 to name a mouse who might turn out to be the longest-lived in history... 🤞 levf.org/eoy-2023#rewards

RMR1 update #10 - screenshotted from FB as usual.

We're less than halfway through our first Robust Mouse Rejuvenation study, and the results are already very exciting. See for yourself! Our plan for the second study is also now available (t.ly/-JVSI). Please donate (t.ly/OZnx3) to help make it happen :)

In honour of #GivingTuesday we’ve upgraded our EOY campaign (t.ly/OZnx3) with a bundle of rewards - including the chance to name a mouse, exclusive Robust Mouse Rejuvenation goodies, tickets to Longevity Summit Dublin 2024 - and even the chance to meet the mice!

LEVF are proud of what we've achieved in our first year of operation, and we hope you'll agree. Visit t.ly/OZnx3 for a summary of our work so far, as well as our plans for 2024 - and please help to make those plans a reality, by joining our end-of-year fundraiser! Our team and collaborators have been working hard to realize the ambitious goal for which the Foundation was established — to facilitate progress in the development, approval, and widespread availability of treatments to comprehensively target aging and its diseases. Over the last year, we've: * Launched the first study in our flagship Robust Mouse Rejuvenation program; * Assembled over 100 expert signatories on the Dublin Longevity Declaration; * Provided seed funding to Keinice Bio to enable “off-the-shelf” organ transplants; * Co-hosted the second Longevity Summit Dublin; * Supported our partners at the Healthspan Action Coalition, Alliance for Longevity Initiatives and AfroLongevity. Of course, none of the projects we've initiated would have been possible without the unfaltering belief and generosity of our donors. We’re tremendously grateful to each and every person who has enabled our vital work to progress so rapidly. Thank you all!

Finally RMR1 update #9! Deepest apologies for the long delay. Herewith the customary screenshots from FB.