Accelerating the development of new medicines @medableinc. Founder CEO, dermatologist & inventor who loves building with great teams

Joined April 2012
571 Photos and videos
Michelle Longmire retweeted
As a result of a US government directive, we are suspending access to Claude Fable 5 for all users. You can continue to use all other Claude models. Here’s what this means for you: Across Claude products, new sessions will run on your selected default model or Opus 4.8, and existing Fable 5 sessions will end with an error. On the Claude Platform, requests to Fable 5 will also return an error. Please update your integrations to other Claude models. We know this is a disruption to your workflows; we appreciate your patience and support.
The US government, citing national security authorities, has issued an export control directive to suspend all access to Fable 5 and Mythos 5 by any foreign national, whether inside or outside the United States, including foreign national Anthropic employees. The net effect of this order is that we must abruptly disable Fable 5 and Mythos 5 for all our customers to ensure compliance. Access to all other Claude models is not affected. We apologize for this disruption to our customers. We believe this is a misunderstanding and are working to restore access as soon as possible. Read our full statement: anthropic.com/news/fable-myt…
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Aha moments in science are one of the greatest joys of the human experience
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Hi [PEJORATIVE], your [SLOP] is not needed. Go [ACTION] your email up your [ORIFICE].
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Disagree with @Bridgebio here. There is SO much room to improve trial timelines (and cost). The same argument was made against lean manufacturing. ‘You can’t compress a production run. You can’t generate the parts we don’t have yet.’ What Toyota proved is that 40% of factory downtime wasn’t inherent to making cars — it was coordination failure, batch thinking, and invisible bottlenecks. Real-time sensor data didn’t compress the weld time. It eliminated the white space around it. Trials have the same problem. The 45% white space isn’t biology — it’s logistics.
AI can't compress a clinical trial. It can't generate the data we don't have yet. Our CEO Neil Kumar pushed back on the AI hype with @bloomberg at #MIGlobal with @MilkenInstitute – not because the tools aren't valuable, but because the years still take years.
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Finally some hope for pancreatic cancer 💜
Incredible #ASCO26 moment. Dr. Brian Wolpin, presenter of the daraxonrasib study, received a standing ovation DURING his talk after he stated the survival benefit for PDAC patients. It was sustained. Cheering. I have never see anything like it in the middle of a talk. $RVMD
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Incredible lecture …
*New Lecture* Stanford @CS153Systems '26, Session 8 The Compute Behind Intelligence with Jensen Huang from @nvidia full link in comment - this clip is just the one where he talks about tomatoes
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Spotted in Tokyo
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When your coworkers also grew up in @LosAlamosNatLab @morrismarkw
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Tokyo in the rain
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Los Alamos from above with snow on the Sangre de Cristos
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Go @medableinc 🔥
Medable wins the 2026 Fierce Outsourcing Award for 'Digital Transformation Partner.' 🏆 This achievement celebrates the best in quality, creativity, and influence within the outsourced drug development ecosystem. Our team is proud to be recognized for scientific rigor, operational excellence, and trusted partnership throughout the clinical trial lifecycle. ________ #clinicaltrials #clinicalresearch #healthcare #digitalhealth
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Michelle Longmire retweeted
Medable wins the 2026 Fierce Outsourcing Award for 'Digital Transformation Partner.' 🏆 This achievement celebrates the best in quality, creativity, and influence within the outsourced drug development ecosystem. Our team is proud to be recognized for scientific rigor, operational excellence, and trusted partnership throughout the clinical trial lifecycle. ________ #clinicaltrials #clinicalresearch #healthcare #digitalhealth
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Totally agree with @patrickc - even as an MD, I found knowing the risks in my genome life changing. I was able to make changes in my behavior that I had wanted to for years, once I understood that I was an outlier (in a negative way) in genetic risk for certain conditions. I used @SequencingCom bc you access my raw genomic data directly.
I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
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Being underestimated is an advantage 🚀

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I simply do not understand why anyone would use Apple Maps …
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Why are they not playing Pink Floyd rn?
Apr 6
LIVE: Watch with us as the Artemis II astronauts make their closest approach to the Moon, traveling farther from Earth than ever before. x.com/i/broadcasts/1dGYljDRv…
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