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Lupoli Lab @LupoliLab
Joined January 2020
  • Tweets 52
  • Following 76
  • Followers 261
16 Photos and videos
Congrats to Zixuan, Max and Aweon on our collaborative work with the Zhang Lab at NYU that combines virtual screening and biochemical assays! ProMol_Func: A Structure-Free Deep Learning Model for Virtual Screening | JACS Au pubs.acs.org/doi/full/10.102…

ProMol_Func: A Structure-Free Deep Learning Model for Virtual Screening

In computational-aided drug discovery, structure-based drug design models are computationally intensive and rely on protein structures, limiting their scalability and generalization. Additionally,...

pubs.acs.org
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Check out this mini-review by Sterling on current protein folding sensors for cells: Genetically encodable biochemical sensors for monitoring protein foldi... sciencedirect.com/science/ar…
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Congrats to Maggie, Andrea, Mia and Hanee for this work w/ collaborators Joseph and Matt Jorgenson! Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in Escherichia coli by altering related metabolite levels | PNAS pnas.org/doi/10.1073/pnas.25…

Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in Escheric...

The cell surface of gram-negative Escherichia coli is rich in glycoconjugates, including O-antigen (O-Ag) and enterobacterial common antigen polysa...

pnas.org
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Lupoli Lab@LupoliLab
25 Nov 2025
Congrats to Hersa, Joanna and Mia on our latest work looking a rare sugar epitopes: Microbial Surface Glycan Probe Isolates Anti-l-Rhamnose Antibodies from Human Serum for Bacterial Detection | ACS Infectious Diseases pubs.acs.org/doi/10.1021/acs…

Microbial Surface Glycan Probe Isolates Anti-l-Rhamnose Antibodies from Human Serum for Bacterial...

Bacterial strains are distinguished by surface glycans composed of defined sugar sequences that include “rare” monosaccharides, which are absent in human glycans and help to mediate host–microbe...

pubs.acs.org
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Lupoli Lab@LupoliLab
20 Aug 2025
Biochemical Applications of Microbial Rare Glycan Biosynthesis, Recognition, and Sequencing | Biochemistry pubs.acs.org/doi/10.1021/acs… Congrats to Joanna, Andrea, Hanee, Antara, Seayoung and Mia on their review on the many biochemical applications of "rare" sugars.

Biochemical Applications of Microbial Rare Glycan Biosynthesis, Recognition, and Sequencing

While humans utilize approximately ten building blocks, hundreds of “rare” sugars exist, which are absent in mammals but present in microbes, plants, and other natural sources. In addition to the...

pubs.acs.org
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Congrats to Hanee on these new routes to glycan probes! Defined Glycan Ligands for Detecting Rare l-Sugar-Binding Proteins | Journal of the American Chemical Society pubs.acs.org/doi/full/10.102…

Defined Glycan Ligands for Detecting Rare l-Sugar-Binding Proteins

Most cells are decorated with distinct sugar sequences that can be recognized by carbohydrate-binding proteins (CBPs), such as antibodies and lectins. While humans utilize ten monosaccharide building...

pubs.acs.org
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Congrats Nathan, Isabelle, Eric, Sam C. and Chao on this collaborative work with the Zhang lab (@nyuchemistry) and NYU Langone! A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13 | ACS Chemical Biology pubs.acs.org/doi/10.1021/acs…

A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a critical need to discover more effective antivirals. While therapeutics for SARS-CoV-2 exist,...

pubs.acs.org
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Lupoli Lab@LupoliLab
16 Jun 2024
Great line-up at the NYU Pride Symposium last Friday (including Sterling Sandler in the morning session)! @nyuchemistry
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Thanks to NYAS and all the great speakers/presenters (including our own Hanee Kim!) at the year end meeting of the Chemical Biology Discussion Group! Looking forward to the next one! @Yael_David__ @aroralabnyu @NYASciences
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Lupoli Lab retweeted
NYAS
@NYASciences
10 May 2024
The Chemical Biology Discussion Group End-of-Year Symposium: Deconvoluting Protein Networks is fast approaching! Register now to join the discussion in NYC! bit.nyas.org/3xr8k5l
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Lupoli Lab@LupoliLab
24 Apr 2024
Congrats to David Sherman and coworkers on their work! pnas.org/doi/10.1073/pnas.23…

The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamics | PNAS

Nonalcoholic fatty liver disease, recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a progressive metabolic dis...

pnas.org
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Lupoli Lab@LupoliLab
29 Mar 2024
Nice talk by Gideon on peptide-based probes in our Friday afternoon student talk series! @nyuchemistry
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Lupoli Lab retweeted
Yael David@Yael_David__
27 Mar 2024
Very excited to team up with @LupoliLab @nyuniversity @nyuchemistry in organizing the End of Year Chemical Biology Symposium, which will take place 6/6 @WeillCornell! Plenty short talks and poster presentations available for our NYC Chem Bio community! events.nyas.org/event/bc29f8…

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Nathan presenting the latest data on viral helicase inhibitors as part of a collaboration with the Zhang lab @nyuchemistry!
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Lupoli Lab@LupoliLab
19 Jan 2024
Congrats to Hanee on finishing up the week with a talk on her new rare sugar routes!
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Zixuan presents her joint work with the Zhang lab in the first research in progress of 2024!
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Lupoli Lab@LupoliLab
21 Dec 2023
Congrats to Aweon on the 2024-2025 Ted Keusseff Fellowship from NYU GSAS to support her dissertation completion!
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Best of luck to Prof. Meng Zheng on his first week in the Department of Chemistry at Fordham University!
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Lupoli Lab@LupoliLab
31 Aug 2023
Congrats to Brock and Nathan on their latest work with modified J-proteins! Bacterial J‐Domains with C‐Terminal Tags Contact the Substrate Binding Domain of DnaK and Sequester Chaperone Activity - Nelson - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibra…

Bacterial J‐Domains with C‐Terminal Tags Contact the Substrate Binding Domain of DnaK and Sequester...

J-proteins are cofactors that assist molecular chaperones in cellular protein folding. We have found that short C-terminal tags added to the N-terminal domains of J-proteins (J-domains) can promote...

chemistry-europe.onlinelibrary.wiley.com
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Lupoli Lab@LupoliLab
28 Jul 2023
Check out Aweon's short review on how different peptide scaffolds have been used to modulate chaperone function. Congrats Aweon! Peptide-based molecules for the disruption of bacterial Hsp70 chaperon... sciencedirect.com/science/ar…
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