Movement Disorders Clinical Practice is the exclusively online Journal of the International Parkinson and Movement Disorder Society (MDS) @movedisorder.
Joined November 2018
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262 Photos and videos
Key lessons from molecular imaging in genetic PD:
• Changes detectable before symptoms
• Non-dopaminergic systems matter early
• Patterns differ by mutation (GBA vs LRRK2 etc.)
Imaging may guide prognosis, cognition & treatment choices
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PD is a disease of uncertainty, and intolerance of uncertainty drives anxiety, avoidance & ↓QoL.
Clinicians: ask about it!
It’s modifiable: CBT/ACT/mindfulness may help.
Treat the uncertainty, not just the motor symptoms loom.ly/5kOko2o
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New MDCP Pearl: Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study loom.ly/5kOko2o
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Motor improvement ≠ life improvement.
After STN-DBS, patients rated real-world functioning ~7.7/10—yet genetics (GBA) and sex tracked more with socio-occupational outcomes than the usual clinic scores.
We need outcomes that reflect living, not just moving. loom.ly/JkeP8t4
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Cervical dystonia has 2 big phenotypes:
-Early onset (35y) = much worse pain/mood/QoL vs later onset (48y) — motor severity differences are smaller.
-Don’t “BoNT-and-bye”: treat the non-motor load. loom.ly/C2cZIOc
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PD & fractures: we’re missing the mark.
Only 12% on bone protection pre-fracture → just 53% @48wks post-fracture.
-Men, rib #, care home residents = least treated
-Vertebral # drives treatment—but shouldn’t be the trigger
-Think bone health EARLY in Parkinson’s
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The Japanese anime character Naruto Uzumaki has for generations inspired children and adults. in this study Naruto's running style was observed and described in children and interpreted as a evidence of a cultural meme rather than a pathological disorder of movement. loom.ly/hclviEI
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Continuous subcutaneous apomorphine infusion (CSAI) may benefit selected patients with multiple system atrophy. In a French multicenter cohort (n=50), CSAI improved motor symptoms in 90% at 6 months, with acceptable tolerability. #MSA #Parkinsons #DAT #Apomorphine loom.ly/BL2WFJo
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Among PDRD patients with significant palliative needs, nearly half had an ED visit and one in five were hospitalized annually. Home-based services were used by over a third. Acute care use remains substantial underscoring gaps in supportive care delivery. loom.ly/ni_LYAc
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Foslevodopa/foscarbidopa improves urinary disturbances, nocturia and quality of life in PD patients. Both overnight continuous dopaminergic stimulation and increasing the total dose of L-dopa contribute to improve overactive bladder. loom.ly/7apCuI8
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The 'Swallow Tail Sign' gets an upgrade!
Absence of dorsolateral nigral hyperintensity on SMWI is a robust, reproducible marker of neurodegenerative parkinsonism—works early, survives real‑world controls, and fits existing MRI pathways! @movedisorder loom.ly/VaFEiNw
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MRgFUS thalamotomy shows strong tremor control even in patients ≥80 — with 95.6% improving and side‑effect rates similar to younger adults.
Learning point: Age alone shouldn’t exclude MRgFUS; balance issues are common but usually improve or resolve. movementdisorders.onlinelibr…
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Two siblings with BCL11B‑related early‑onset dystonia showed striking, long‑lasting motor improvement after GPi‑DBS,with >50% BFMDRS-M reduction. A reminder that genetic dystonias can be highly DBS‑responsive—mutation type, phenotype & timing matter. movementdisorders.onlinelibr…
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Exocrine dysfunction in PD is common & early—drooling, dry mouth/eyes, seborrhea, rhinorrhea, sweating & GI issues all reflect autonomic α‑synuclein pathology.
Clinician tip: Ask about these symptoms—they’re underrecognized but highly impactful! movementdisorders.onlinelibr…
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Subcutaneous foslevodopa/foscarbidopa (fLD/fCD) was thought to overcome systemic and nutritional complications of LCIG therapy, but peripheral neuropathy can still emerge.
Baseline ongoing vitamin & nerve monitoring recommended! movementdisorders.onlinelibr…
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New scoping review highlights how FXTAS remains under diagnosed in Latin America.
Key takeaways:
• Classic signs = ataxia & intention tremor
• Cerebral atrophy more common than MCP sign
• Atypical phenotypes (spasticity, PSP‑like, rapid dementia)
• Urgent need for better access to genetic testing & clinician awareness
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A global MDS member survey on career and work environment found pronounced gender disparities in the field. Data were proportionally representative of Pan-America, Asia-Oceania, Europe, and Africa. @movedisorder movementdisorders.onlinelibr…
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New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. @AMahajanMD @UCMovDis movementdisorders.onlinelibr…
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The Parkinson’s Pals program reduced loneliness and demoralization in pwPD after just 8 virtual sessions, while boosting student PD knowledge. Low‑cost, scalable psychosocial care in action! loom.ly/-dCdb0U
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New MDCP Pearl: Digital Gait Measures Discriminate People with Friedreich's Ataxia from Healthy Controls loom.ly/WPtnCjQ
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