This new preprint might make some noise.
One of the central assumptions in social neuroscience is that the right dorsolateral prefrontal cortex is involved in prosocial decision making.
Neurostimulation studies using TMS and tDCS are often cited as providing the strongest causal evidence for this claim.
In this new paper, we meta-analyzed two decades of studies that stimulated the rDLPFC while participants made economically incentivized decisions involving costly prosocial behavior.
At first glance, the results look exactly as expected:
Exciting the rDLPFC leads to more prosocial behavior,
Inhibiting the rDLPFC leads to less prosocial behavior.
We also find something new in the literature and potentially interesting: stimulating the rDLPFC has a particularly strong effect on positive and negative reciprocity.
However, when we start controlling for publication bias a disaster happens.
Not even one estimation remains credibly different from zero:
Overall effect? Not credibly different from zero
Excitatory stimulation? Not credibly different from zero
Inhibitory stimulation? Not credibly different from zero
Prosocial domain-specific effects? Not credibly different from zero or dramatically underpowered.
TMS studies? Not credibly different from zero
tDCS studies? Not credibly different from zero
A total disaster.
Overall, these findings raise questions about the robustness of one of the most widely cited claims in social neuroscience and neuroeconomics, and highlight the need for well-powered replication studies and stronger incentives to publish null results.
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preprint in the first reply
joint work with Leticia Micheli