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Miguel Ramalho-Santos Lab @MRSantosLab

The Miguel Ramalho-Santos Lab does research on Developmental Epigenetics at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto, Canada.

Joined February 2018
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Miguel Ramalho-Santos Lab@MRSantosLab
2 Jan 2025
Learn more about the lab's research and news at: mrsantoslab.org and bsky.app/profile/mrsantos.bs…

Santos Lab

mrsantoslab.org
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The #LTRI in Toronto is a diverse and inclusive community in a multicultural city: we encourage candidates from underrepresented groups to apply! 2 PI positions, by Oct 20. #womeninscience #BlackandSTEM #NativeinSTEM #NativeScience #LatinXinSTEM #MarginSci #DiversityinSTEM 👇
Sinai Health@SinaiHealth
10 Sep 2025
Job Alert 🚨 We are looking for outstanding candidates to join our institute! Find out more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529
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🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @SinaiHealth. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost!
Sinai Health@SinaiHealth
10 Sep 2025
Job Alert 🚨 We are looking for outstanding candidates to join our institute! Find out more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529
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Ending 2024 in style! We found that LINE1s are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together 2 facets of Barbara McClintock’s pioneering work: nucleolar organizer regions and transposable elements. genesdev.org/cgi/doi/10.1...
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Also noted: Ribosomal DNA copy number is associated with body mass in humans and other mammals. rdcu.be/dZ3q3
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Discussed in @MRSantosLab lit review: Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration: Cell cell.com/cell/fulltext/S0092…

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration

ERV suppression is an essential pathway to protect adult stem cells in somatic regenerative tissues. Stem cell activity-coupled ERV silencing enables lineage progression during adult tissue regener...

cell.com
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Happy Halloween!
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Miguel Ramalho-Santos Lab retweeted
Sinai Health@SinaiHealth
15 Oct 2024
In a groundbreaking discovery, Sinai Health researchers have found that transposable DNA elements – long considered “junk DNA” because they had no known function – are critical for early human development. Congrats to Dr. Ramalho-Santos & team at LTRI! sinaihealth.ca/news/new-rese…

New research unveils key role of “selfish DNA” in early human development | Sinai Health

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

sinaihealth.ca
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📢@MRSantosLab - LINE1 RNA prevents developmental reversion of human embryonic stem cells to the 8 cell-like state! new insights on PRC2, nucleolus and chr. 19. Revised and expanded now @Dev_Cell, free access until Dec 4th (earlier version on bioRxiv): authors.elsevier.com/a/1jxLO…
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Highlights: -Knockdown of LINE1 RNA induces reversion of naive hESCs to 8C-like cells -LINE1 RNA and PRC2 maintain nucleolar architecture in hESCs -Disruptions of the nucleolus de-repress the 8C program -Chr19 is enriched for 8C genes and dissociates from the nucleolus in 8CLCs
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📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.1101/… 👇Key findings:

LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells

The family of LINE1 transposable elements underwent a massive expansion in mammalian genomes. While traditionally viewed as a mutagenic selfish element, recent studies point to roles for LINE1 in...

biorxiv.org
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The results point to a conserved role for LINE1 in repression of developmental reversion in both mouse (@MPercharde et al, Cell 2018) and human. The findings raise fascinating questions regarding transposon evolution and their role in genome compartmentalization.
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Excellent team effort driven by postdoc Juan Zhang @LesleyZ618, working with Lamisa Mizan @mizanlam and Kirti Mittal in our lab, and in collaboration with Miguel Esteban, @jeffwranalab and @michaelhoffman. Thanks to all! Watch this space for an update in the next few months…
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Recent review from @MRSantosLab. Everything you wanted to know about hypertranscription but were afraid to ask! This review discusses concepts of hypertranscription & technological advancements to probe global transcriptional shifts in stem cell biology. cell.com/trends/genetics/ful…
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Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions. mrsantoslab.org

Santos Lab

mrsantoslab.org
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MRS reported latest from our lab on LINE1 in hESCs #ISSCR2024, Hamburg. Great to reconnect with many colleagues, @bulutkarslioglu @EveCollignon. Excellent science, massive industry show. For respite: Art Museum, Caspar David Friedrich, “Wonderer above the sea of fog”, 1817.
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