C3 glomerulopathy is a rare disease resulting from an overactivation of the complement alternative pathway. This study found intra-renal terminal pathway activation was associated with specific histological phenotype & disease prognosis in this population bit.ly/JASN0373
ALT Histological and C5b-9 deposits evaluation in C3 glomerulpathy
(a) Representative images of main glomerular patterns: membranoproliferative on the left (arrow indicates glomerular basement membrane duplication) and mesangioproliferative on the right (arrow indicates mesangial cell hypercellularity). Two kidney biopsies did not belong to either of this two patterns: one showed extensive mesangial and parietal deposits, and the other one displayed non significant glomerular lesions on light microscopy (b) C3 glomerulopathy histological index quantification in kidney biopsies: activity and chronicity scores. Violin plot, each individual value is represented by a point. (c) Representative images of glomerular C5b-9 in negative control and C3 glomerulopathy biopsies classified as no/low, intermediate and high. (d) Repartition of kidney biopsies among the 3 glomerular C5b-9 groups.
You need a reliable measurement of many #complementbiology biomarkers at the same time?
Read our new paper about the multiplex assay for complement biomarkers in plasma!
Congratulations @MSMeuleman@Duval_anna_ MA Dragon-Durey and team! Happy to take part
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Petite enquête: Ça vous tenterait de faire un DU « complément et maladies » qui traiterait de tous les aspects diagnostiques, physiopathologiques et thérapeutiques du complement en médecine?
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