Shining light on organic chemistry
Joined June 2015
- Tweets 1,248
- Following 130
- Followers 22,779
- Likes 384
732 Photos and videos
Cheers to Eva Lin and Lauren Harstad for an awesome Third Year Seminar!
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Congrats to Jennifer Nguyen and William Zhao for a brilliant Third Year Seminar talk!
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MacMillan Group retweeted
The David MacMillan Lab @macmillan_lab advances a couple-close strategy to make “the impossible, possible.” Great work Jiaxin (Jay), Will, Johnny, Will, Noriyuki, Alice, Taylor, Chris, Marian, Dave!
Enjoy our story on the lab’s new research in Science: bit.ly/4lnjNrA
ALT Full-color image of member of the MacMillan Lab at his bench.
ALT Graphical journal illustration.
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Cheers to Taehyun (Tae) Kim, Min Sun (Esther) Kang, and Zihan (Blair) Dong for delivering an awesome Third Year Seminar!
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We will miss you, Yuki! We wish you the best of luck, and it was a pleasure working with you in the lab!
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Huge congrats to Will, Inji, and Eli on passing their generals exams! 🎉👏 Major milestone achieved—so proud of our grad students! 🧪✨
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22 Oct 2025
We’re hiring a postdoc in collaboration with J&J! The position will be split between our lab and J&J’s Spring House site. We’re looking for someone with a strong chemistry background ideally with expertise in photochemistry and developing photocatalysts.
jj.wd5.myworkdayjobs.com/JJ/…
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10 Oct 2025
Our recent JACS paper unveils a metallaphotoredox platform enabling N-alkylation with alcohols, acids, or halides — even in complex drugs & peptides! Opening the door to new C(sp³)-rich drug designs. Congrats, Johannes, Danielle, and Aimee!
pubs.acs.org/doi/10.1021/jac…
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9 Sep 2025
Our latest μMap platform in action on @ChemRxiv! In collaboration with BMS we efficiently deconvolute MoAs from a large phenotypic screen, uncovering BACH2 degraders that act via upstream kinases & harness LONP1. A powerful example of rapid MoA resolution
chemrxiv.org/engage/chemrxiv…
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27 Jun 2025
Old tissue, new tricks??
We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples.
📃: doi.org/10.1021/jacs.5c06489
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MacMillan Group retweeted
20 May 2025
With thanks to these esteemed early-career researchers Steve, Sijbren, Alex, Kristina, and Erik who presented at yesterday’s Princeton Catalysis Initiative Symposium opener. Well done, all.
ALT Full-color image of researchers standing at the entrance of Princeton Chemistry's Taylor Auditorium.
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25 Apr 2025
‘Tis the season! Here, Noah Bissonnette of the @MacMillan_Lab during his dissertation defense, and being introduced by adviser David MacMillan.
Best of luck to all graduate students defending this spring! You are our future.
ALT Full-color image of Taylor Auditorium with seated students and grad student upfront presenting.
ALT Full-color image of audience at Taylor Auditorium and P.I. upfront introducing his advisee.
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24 Apr 2025
Alcohols aryl acids = C(sp3)–C(sp2) bonds! In collaboration with @LongLabCal & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan!
pubs.acs.org/doi/10.1021/jac…
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MacMillan Group retweeted
18 Apr 2025
Thrilled to announce that Brandon Bloomer of the @MacMillan_Lab has been named a 2025 @BeckmanFnd Postdoctoral Fellow in the chemical sciences, one of just 14 across the country.
Congratulations, Brandon! Announcement here: bit.ly/3S1KAvr
ALT Head-and-shoulders image of Brandon standing in Frick Lab at Princeton Chemistry.
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16 Apr 2025
Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat!
Give it a read here: cell.com/chem/abstract/S2451…
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29 Mar 2025
Want to selectively couple two radicals?... You're in luck!
Check out our newest work in Nature where we use dynamic orbital selection to unlock alkylation of native aryl C–H bonds.
Congrats to @GrosskopfJo, Charlene, Robert, and Alex!
Read more at: nature.com/articles/s41586-0…
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MacMillan Group retweeted
17 Mar 2025
Spring into some great seminars from @POCC_Chem ! Next week's installment is @PrincetonChem very own @dmac68 for our Allan Day award lecture. Prof, MacMillan will be discussing research from @MacMillan_Lab including organocatalysis, photoredox catalysis, and microenvironment mapping. Join us on Thurs 3/27 at 6:30 PM for food/drinks with the talk kicking off at 7:30 at @PennChemistry !!!
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9 Jan 2025
Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain!
pubs.acs.org/doi/10.1021/jac…
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MacMillan Group retweeted
22 Dec 2024
Parallel Proteomic & Transcriptomic Microenvironment Mapping (μMap) of Nuclear Condensates in Living Cells Journal of the American Chemical Society @dmac68 @MacMillan_Lab @PrincetonChem #Proteomic #Transcriptomic #Mapping #Nuclear #Condensates #LivingCells pubs.acs.org/doi/10.1021/jac…
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