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The Magauer Lab @MagauerGroup

Synthesis and Synthetic Methodology

Joined March 2019
  • Tweets 141
  • Following 252
  • Followers 2,559
53 Photos and videos
The Magauer Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
5 Dec 2025
Unified Total Synthesis of Phrymarolin and Haedoxan Natural Products | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Unified Total Synthesis of Phrymarolin and Haedoxan Natural Products

We disclose a unified synthetic route to the furofuran lignans phrymarolin I and II as well as the insecticidal natural products haedoxan A and D. The furofuran core was constructed using a formal [3...

pubs.acs.org
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Congrats to Jan for successfully passing his PhD defense! We wish you all the best for your future career!
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The Magauer Lab retweeted
ChemistryEur@ChemistryEur
13 May 2025
Evolution of a Strategy for the #TotalSynthesis of the Ganoderma Meroterpenoid Ganoapplanin by Thomas Magauer and co-workers (@MagauerGroup) #OpenAccess 🔓 onlinelibrary.wiley.com/doi/…

Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin

Herein, the development of the first total synthesis of the Ganoderma meroterpenoid ganoapplanin is presented. Insights from unsuccessful approaches guide the design of an efficient route centered...

chemistry-europe.onlinelibrary.wiley.com
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The Magauer Lab retweeted
Ondrej Kovac@OndrejKovac1
28 Apr 2025
The final chapter of the Ganoapplanin story is here! Check out our team’s effort (@MagauerGroup ) toward this complex meroterpenoid. Great chemistry and experience! chemistry-europe.onlinelibra…

Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin

Herein, the development of the first total synthesis of the Ganoderma meroterpenoid ganoapplanin is presented. Insights from unsuccessful approaches guide the design of an efficient route centered...

chemistry-europe.onlinelibrary.wiley.com
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The Magauer Lab retweeted
Total Synthesis
@TotalSynthesis
10 Apr 2025
#TotalSynthesis of Dactyloquinone A and Spiroetherone A via a Metal-Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol–Enedione Rearrangement by Guillaume Schoenn, Cyrille Kouklovsky, Régis Guillot, Thomas Magauer (@MagauerGroup), and Guillaume Vincent (@GVincentUPSUD) in @angew_chem onlinelibrary.wiley.com/doi/…
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Last week, our Master's student Daniel successfully defended his MSc thesis. Congratulations! All the best for your future career.
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Congrats to Immanuel for successfully passing his PhD defense! We wish you all the best for your future endeavours!
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Congrats to Jan and Christian for their intriguing total synthesis of the maleidride natural products glauconic acid and glaucanic acid, achieved through an intramolecular alkylation strategy doi.org/10.1039/D4SC08332F

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Also congratulation to our PhD student Aldo for his successfull collaboration with the Tollinger group, resulting in a publication in @JPhysChem pubs.acs.org/doi/10.1021/acs…

Refining Ligand Poses in RNA/Ligand Complexes of Pharmaceutical Relevance: A Perspective by QM/MM...

Predicting the binding poses of ligands targeting RNAs is challenging. Here, we propose that using first-principles quantum mechanics/molecular mechanics (QM/MM) simulations, which incorporate...

pubs.acs.org
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Our latest publication in @NatureChemistry describes a non-enzymatic methylcyclization of alkenes, mimicking the reactivity of Nature’s C-methyltransferases. Congrats to Immanuel, Elias and Sebastian! nature.com/articles/s41557-0…

Non-enzymatic methylcyclization of alkenes

Nature Chemistry - Bifunctional methyltransferase–cyclases both transfer a methyl group to alkenes and induce cyclization—a process called methylcyclization. Now a non-enzymatic...

nature.com
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And also congrats to Nico and Ondrej for the acceptance of their @synlett_journal paper about the "Development of a Triethylborane Mediated Giese Cyclization/Aldol Reaction Cascade for the Total Synthesis of Ganoapplanin" thieme-connect.com/products/…
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Congrats to the Pimarane-Team for the acceptance of their article "Development of a Synthetic Platform for Ent‐Pimaranes Reveals their Potential as Novel Non‐redox Active Ferroptosis Inhibitors" in Chemistry - A European Journal (@ChemEurJ) chemistry-europe.onlinelibra…

Development of a Synthetic Platform for Ent‐Pimaranes Reveals their Potential as Novel Non‐Redox...

A full account of five distinct synthetic strategies towards a subfamily of ent-pimaranes is given. Highlights include radical and cationic polyene cyclizations for construction of the tricyclic...

chemistry-europe.onlinelibrary.wiley.com
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Today, our department had the pleasure of hosting @KarlGademann for an inspiring presesentation on microbiome metabolites and engaging discussions. Grateful for the insights and perspectives!
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Take a look at our latest work on the synthesis of ganoderma meroterpenoids published in @JOC_OL! Congratulations to Alex and Team Ganoderma! pubs.acs.org/doi/10.1021/acs…

A General Entry to Ganoderma Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone...

Ganoderma meroterpenoids are fungal derived hybrid natural product class containing a 1,2,4-trisubstituted benzene ring and a polycyclic terpenoid part. The representatives applanatumol E, H and I,...

pubs.acs.org
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Last week, our PhD students Jan and Nico attended the 6th Boehringer Ingelheim MedChem PhD course. It was a great opportunity to gain insights into research in an industrial setting. Many thanks for the invitation @Boehringer
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The Magauer Lab retweeted
Ondrej Kovac@OndrejKovac1
14 Oct 2024
Ganoderma meroterpenoids strike back! Check out the latest contribution in @JOC_OL from @MagauerGroup. Congrats to Alex and Team Gano. pubs.acs.org/doi/10.1021/acs…

A General Entry to Ganoderma Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone...

Ganoderma meroterpenoids are fungal derived hybrid natural product class containing a 1,2,4-trisubstituted benzene ring and a polycyclic terpenoid part. The representatives applanatumol E, H and I,...

pubs.acs.org
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Yesterday, we had the pleasure of welcoming @HeretschPhilipp to our institute, where he shared his exciting research on radical chemistry in natural product synthesis. It was a fantastic talk with engaging discussions! We really enjoyed having you with us.
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Last week, our PhD student Nico attended the ASTS-NDM conference (The Art and Science of Total Synthesis of natural and designed molecules for biology and medicine) in Paris, where he presented our latest findings on natural product synthesis!
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Yesterday, our group had the opportunity to present some of our latest work at the 9th CMBI meeting in Igls. A big congratulations to Immanuel for winning the Speaker Award!
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Congratulations to Liesa on her successful PhD defense. All the best for your future career!
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