This is really cool (and wild): Scientists simulated a complete living cell for the first time. Every molecule, every reaction, from DNA replication to cell division. The paper (Luthey-Schulten et al., Cell 2026, doi.org/10.1016/j.cell.2026.…), just out today, used JCVI-Syn3A — a synthetic minimal bacterium with fewer than 500 genes. A 3D time simulation of the full 105-minute cell cycle: DNA replication, protein translation, metabolism, division. Every gene, protein, RNA, and chemical reaction tracked through physical space. It took years to build. Multiple GPUs. Six days of compute time per run. And this is the simplest possible cell. A human cell has ~20,000 genes. It lives in tissue. It interacts with neighbors. It differentiates. It responds to drugs in ways that depend on context we haven't fully measured. Mechanistic simulation of the minimal cell costs 6 GPU-days for 105 minutes of biology. You cannot scale that to human cells. The complexity isn't 40x harder. It's exponentially harder. This is why the field pivoted to data-driven models. You can't hand-encode the regulatory wiring of a human hepatocyte. But you can learn it — if you have the right perturbation data collected across enough diverse biological contexts. The two approaches aren't competing. Papers like this generate the ground truth that future ML models need for validation. But the path to a clinically useful virtual cell runs through foundation models, not through scaling up mechanistic simulation. Amazing work!

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New preprint alert! We've uncovered the role of the microtubule-associated protein Ccdc66 in maintaining the stability and disassembly of the primary cilium. Our findings reveal how Ccdc66 depletion leads to unstable cilia and affects signaling pathways like Hedgehog and Wnt.

Save the date! March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳 Stay tuned for more info!