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Ajay Mathuru @MathuruLab

The question that drives our research @yalenus is to gain a better understanding of how #brains operate and generate #behavior; #mechanisms.

Joined April 2020
  • Tweets 70
  • Following 56
  • Followers 123
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Ajay Mathuru@MathuruLab
12 Jun 2024
Happy to announce our recent study on “Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion” came online over the weekend. rdcu.be/dKeoU

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Ajay Mathuru retweeted
Tirtha Das Banerjee@TirthaDasBaner1
12 Dec 2024
Our new manuscript describing gene multiplexing (using RAM-FISH) is finally out... We profiled multiple known and novel mRNA candidates during different developmental stages of Bicyclus and Danio. biorxiv.org/content/10.1101/… @MonteiroLab @MathuruLab
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chrna3 modulates biphasic response to alcohol biorxiv.org/content/10.1101/… Our preprint on biphasic response to alcohol and the nicotinic acetylcholine receptor subunit chrna3 is out! The lay summary of our findings in the thread below.

chrna3 modulates biphasic response to alcohol

Alcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics are valuable for...

biorxiv.org
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However, chrna3 mutants exhibited a prolonged attraction to alcohol and were less affected by alcohol exposure. These findings suggest that chrna3 dysfunction may contribute to acute alcohol tolerance, potentially playing a significant role in the development of addiction.
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And, a big thank you to a fantastic ongoing collaboration with @TirthaDasBaner1 and Antónia Monteiro, on a number of projects. The spatial expression patterns studied uses a modified HCR tech perfected in-house allowing for expression analyzing in 2-3 week old z.🐟!
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Happy to announce our recent study on “Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion” came online over the weekend. rdcu.be/dKeoU

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However, we conclude we need more research to fully ascertain if iatrogenic transmission by this route is possible when the Aβ sequence similarity between species is higher than it is between zebrafish and humans or there is a long incubation period.
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Great to see what started out as a fun little 💬 with @jangruber467 and @ nicktolwinski a few years ago matured into the HLCA catalyst award and this paper! Congratulations to @ Josh Raine, on his first paper in the lab!
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Evaluating the transmission risk of amyloid beta peptide via ingestion biorxiv.org/content/10.1101/… The answer at the moment, thankfully, seems to be unlikely! Read more ⬆️

Evaluating the transmission risk of amyloid beta peptide via ingestion

Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties in humans. Transmission of Aβ peptide and the development of associated pathologies after surgeries...

biorxiv.org
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Ajay Mathuru retweeted
The Aging Brain Lab@AgingBrainLab
22 Feb 2023
📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis. 🧵A brief thread pnas.org/doi/10.1073/pnas.22… @PNASnews @NTU_LKCMedicine @NTUsg @alzforum #mitochondria #microglia #Alzheimers #Immunometabolism

Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in...

Microglial phagocytosis is an energetically demanding process that plays a critical role in the removal of toxic protein aggregates in Alzheimer’s ...

pnas.org
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Check out the smchd1 story here. nature.com/articles/s41467-0… Had not been thinking about homeotic transformations till this amazing study with @shifengxue and @ReversadeLab. Congratulations 🎉 also to Raunak Vijayakar whose capstone thesis contributed to this publication. His 1st 📝!
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Ajay Mathuru retweeted
Shifeng Xue@shifengxue
24 Jun 2022
Happy to share our latest work on the role of maternal SMCHD1 in regulating #HOX expression @NatureComms with @ReversadeLab @MathuruLab. This project survived a job change, maternity and pandemic. 🧵 nature.com/articles/s41467-0… 1/n

HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformati...

Nature Communications - Hox genes are known to control anteroposterior patterning, including the vertebrate spine. Here Xue et al. show that maternal Smchd1 regulates Hox expression in an...

nature.com
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Hi all, We are hiring! My lab has two open positions. Please write to me with the job title in subject line. Details here - yale-nus.edu.sg/careers/rese… And here - yale-nus.edu.sg/careers/rese… #zebrafishjobs
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Have you been wondering what fish will do if they could self-administer alcohol? Check out our lab's preprint for an answer! #Hormesis, #CRITTA with at James, and @adamcchang. Contingent-behavior assay shows zebrafish preference for alcohol is biphasic biorxiv.org/content/10.1101/…

Contingent-behavior assay system shows zebrafish preference for alcohol is biphasic

Alcohol use disorders are poorly understood, complex, multifactorial phenomena with a very large footprint within the global burden of diseases. Methods to study the development of addiction have...

biorxiv.org
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onlinelibrary.wiley.com/doi/…

Cover Image

The cover image is based on the Original Article Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference by Fatima Megala Nathan et al., https://doi.org/10....

onlinelibrary.wiley.com
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Great to see this work in pre-print! congrats @ Anja and @ Erin Connect with me at Mathurulab for these mutants. Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio) biorxiv.org/content/10.1101/…

Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio...

Zebrafish are highly social teleost fish and an excellent model to study social behavior. The neuropeptide Oxytocin is associated different social behaviors as well as disorders resulting in social...

biorxiv.org
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Fantastic to see this published. Great #Collaboration with IMH, NAMS, and Venki‘s lab @ IMCB on an important problem. #Mentalhealth “Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders…” mdpi.com/1165130, @JCM_MDPI
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Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study mdpi.com/1165130 ##mdpijcm via @JCM_MDPI

Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot...

Genetics intersects with environmental, cultural, and social factors in the development of addictive disorders. This study reports the feasibility of whole-exome sequencing of trios (subject and two...

mdpi.com
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