How much of the blood pressure-lowering effects of GLP1s are due to weight loss?
About 70% (according to this paper)
The remaining 30% probably comes from a mixture of things:
- Relaxation of vessels
- Renal effects (volume off-loading, natriuresis, reduced renin–angiotensin activation)
- Less inflammation, less insulin resistance (= better vascular function)
The new weight loss drugs are roughly as effective for blood pressure-lowering as anti-hypertensives: