Resubmitting my NIH K23 application this week — and feeling grateful for the many people who make clinical research possible.
A sincere thank you to the patients who participate in our studies, our research assistants and coordinators, collaborators and colleagues, my mentorship team, and the reviewers whose feedback helped strengthen this resubmission. Clinical research truly takes a team.
Our PREVENT study has now been ongoing for one year. PREVENT is a prospective observational study of patients presenting to the emergency department with acute (≤4 weeks) neck or low back pain. Over the past year, I’ve learned a great deal about conducting prospective observational research in the emergency care setting.
Importantly, this first year has given us the opportunity to analyze preliminary data, identify barriers to recruitment and follow-up, and revise study procedures to strengthen the next phase of the work. I’m optimistic about what we may learn in year two.
These preliminary data also informed my K23 resubmission, which is focused on building the training and knowledge needed to support development of a screening trigger for Pain-SBIRT (Pain Screening, Brief Intervention, and Referral to Treatment), followed by feasibility and usability work to prepare for a future R21.
Among the first 42 PREVENT participants:
▪️ 16.7% screened positive for depressive symptoms on the PHQ-2
▪️ 9.5% screened positive for anxiety symptoms on the GAD-2
▪️ 39.2% reported at least some difficulty paying for basic needs
▪️ 31.7% reported at least sometimes feeling socially isolated
▪️ 17.1% reported needing assistance with employment or job training
Pain-related psychological factors were also present:
▪️ 11.9% demonstrated clinically elevated pain catastrophizing
▪️ 55% of participants with available data showed moderate or high fear of movement
▪️ 33.3% scored below the clinically meaningful threshold for pain self-efficacy
The figure below offers an early signal: pain catastrophizing, disability, and other markers of psychological risk appear to worsen as social needs burden increases.
These analyses are descriptive and based on a small sample, but they suggest that social vulnerability and maladaptive pain-related beliefs may cluster together among ED patients presenting with acute musculoskeletal pain.
If these patterns continue as PREVENT grows, they may help us identify patients earlier who could benefit from a targeted behavioral intervention.
This work is helping inform the development of Pain-SBIRT — an ED-deliverable behavioral intervention that we hope to refine, test for feasibility and usability, and ultimately evaluate in future studies.
More to come as PREVENT continues.
#ClinicalResearch #PainScience #EmergencyMedicine
#NIH