Please have a look at the new paper of the Low lab @thelowlab. The second take on the Tad pilus system, providing the structural basis of the bidirectional pilus processing by CpaF. Great collaboration with Tung Le @Tung_BK_Le and @EmmaJBanks.
nature.com/articles/s41467-0…
Excited to share a new preprint of the lab! Using native SV2A and cryo-EM we provide the structural basis for tetanus toxin entry into central neurons and reveal the binding mode of the anti-seizure drug Levetiracetam used in the treatment of epilepsy.
biorxiv.org/content/10.1101/…
We're looking for a postdoc and an RA to join us @ucl! Interested in how the #malaria parasite adapts its cytoskeleton for disease transmission? Join our @wellcometrust funded project and use #insitu#CryoET to study parasites! DM or email any questions. Links in the comments.
📢1x PDRA & 1 x PhD position available 📢
@ImperialInfect, @imperialcollege
Building minimal gut microbiome models using 3D printing & fluidics 🖨🦠🤖
PhD deadline : 12 th of January 2024 (home fees)
PDRA deadline: 30 th of January 2024
Apply 👇
mpl-group.github.io/join.htm…
The missing piece in the bacterial #ESCRT-III story.. #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😎😵💫 Wonderful collaboration with @Colom_D@RouxLab… 1/2
biorxiv.org/content/10.1101/…
Excited to share our first exploration of the pilus-forming Tad secretion system in bacteria.. here showing the assembly mechanism of a secretin-pilotin complex.. And congratulations to brilliant @Matteo_tassina for his relentless heroics in the lab 👏
nature.com/articles/s41467-0…
An MFS transporter that extracts lipids from membrane with the help of a lipoprotein?!?🤩
Check out our paper on the fascinating duo of Rv1410 and LprG on @biorxivpreprint!
biorxiv.org/content/10.1101/…
We have funding for a postdoc (3 years) or PhD student (4 years) on an exciting project linking structural biology, microbiology, biochemistry and biophysics. We look for a candidate who has an excellent educational background in one of these fields...
Proud to see our DMS paper out in @nchembio after going through a productive review process🥳EfrCD's drug efflux activity profile determined for >1400 single variants. Identified single mutations that convert the exporter into a drug-specific ABC importer! nature.com/articles/s41589-0…
Following the installation of ALERT, we are very grateful to Brahmal Vasudevan and Shanthi Kandiah for giving @imperialcollege the opportunity to be the setting for a striking new artwork by Antony Gormley, one of the UK’s foremost living artists.
imperial.ac.uk/news/239911/a…
!!We’re still looking to fill this postdoctoral job opening!! 🕺💃Interested in understanding the role and mechanism of ESCRT-III-like membrane remodelling proteins in bacteria?.. then come join us! #Cryoem#CryoET Please retweet!
imperial.ac.uk/jobs/descript……
!!Postdoctoral job opening!! 🕺💃Interested in understanding the role and mechanism of ESCRT-III-like membrane remodelling proteins in bacteria?.. then come join us! #Cryoem#CryoET Please retweet!
imperial.ac.uk/jobs/descript…