Official Journal of @TheUSCAP, focused on clinical and translational research in #pathology of #humandisease. Sibling Journal: @LIjournal.
Joined January 2017
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406 Photos and videos
There might be a CISH, but finding hemosiderin deposition is a poor man's clue.
Dulken BW, et al. CHRNA6 RNA In Situ Hybridization Is a Useful Tool for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma. Mod Pathol. 2024 May;37(5):100464. PMID: 38447752.
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Bread and butter post: Inflammatory cloacogenic polyp is a mucosal prolapse polyp at the junction of rectal glandular mucosa and anal squamous mucosa. Note that the the lamina propria is filled with smooth muscle rather than the usual complement of inflammatory cells.
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Mastocytosis (seen here) is often sought by naive colleagues and seldom seen. Mod Pathol offers a great review:
Panarelli NC, Hornick JL, Yantiss RK. What Is the Value of Counting Mast Cells in Gastrointestinal Mucosal Biopsies? Mod Pathol. 2023 Feb;36(2):100005. PMID: 36853780.
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Zhang AW, et al. Cross-Platform Methylation-Based Site of Origin Classification for Squamous Cell Carcinomas. Mod Pathol. 2025 Nov;38(11):100878. PMID: 40902853.
There is a lot happening with squamous cell carcinoma. This esophageal example has a null p53 expression pattern. Check out this new article!
Zhang AW, et al PMID: 40902853.
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There is a lot happening with squamous cell carcinoma. This esophageal example has a null p53 expression pattern. Check out this new article!
Zhang AW, et al PMID: 40902853.
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This is a gastric mucosal biopsy: The clue to this "one stain diagnosis" is that GISTs seldom involve the mucosa.
Ortiz Requena D, et al. Synovial Sarcoma of the Gastrointestinal Tract. Mod Pathol. 2024 Jan;37(1):100383. PMID: 37972927.
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This is a high power field from a hibernoma (a lipoma showing brown fat differentiation). The nuclei are tiny. These tumors are richly vascularized like brown fat.
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This is an example of fat atrophy in a colon resection from a malnourished patient. It can suggest a liposarcoma but the lobulation is the clue.
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Schneider JW, Eason AB, Chambers M, Su H, Shifflett K, Guo S, Sanderson M, Bruce-Brand C, Burger H, Dittmer DP. Spatial Profiling Shows That Lymphatic Endothelial Cells Form the Core of Kaposi Sarcoma (KS). Mod Pathol. 2026 Feb;39(2):100955. PMID: 41478362; PMCID: PMC12860498.
Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology.
Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.
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Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology.
Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.
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Sande WJ, et al. Extraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization. Mod Pathol. 2025 Mar;38(3):100664. PMID: 39577663.
This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up!
Sande WJ, et al. PMID: 39577663.
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This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up!
Sande WJ, et al. PMID: 39577663.
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Simons M, et al. Two types of primary mucinous ovarian tumors can be distinguished based on their origin. Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
Although there is an association between ovarian primary mucinous tumors and Brenner tumors, in this case, a Brenner tumor has collided with metastatic pancreatic ductal adenocarcinoma.
Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
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Although there is an association between ovarian primary mucinous tumors and Brenner tumors, in this case, a Brenner tumor has collided with metastatic pancreatic ductal adenocarcinoma.
Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
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Iwamura R, et al. PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors, Including Myopericytomas, Angioleiomyomas, Glomus Tumors, and Their Combined Tumors. Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
An interpretation of myofibroma (and some related lesions) can be confirmed by in situ hybridization for PDGFRB.
Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
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An interpretation of myofibroma (and some related lesions) can be confirmed by in situ hybridization for PDGFRB.
Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
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Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin's disease, and various sarcomas. 9578090
Myxoinflammatory fibroblastic sarcoma was first reported in Modern Pathology years ago using descriptive terminology by Sharon Weiss and her colleagues. Reed-Sternberg like cells (large arrows) and an eosinophil are indicated.
PMID: 9578090.
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Myxoinflammatory fibroblastic sarcoma was first reported in Modern Pathology years ago using descriptive terminology by Sharon Weiss and her colleagues. Reed-Sternberg like cells (large arrows) and an eosinophil are indicated.
PMID: 9578090.
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Everyone's onto loss of GI tract plasma cells in patients on CAR T treatment for myeloma, but there is always daratumumab to fool us as well! Modern Pathology comes to the rescue again to help us in practice! Read all about it!
sciencedirect.com/science/ar…
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This pancreatic solid pseudopapillary neoplasm compressed the kidney. There is lots to learn!
He R, et al. Proteomics Profiling Identifies MCM4 as a Prognostic Biomarker for Postoperative Metastasis in Solid Pseudopapillary Neoplasms of the Pancreas. PMID: 41638574.
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