Molecular and Cellular Proteomics (MCP) | Research, perspective, technological innovation and resources, and issues in proteomics articles | Published by @ASBMB
#MolCellProt cover | SOX2 progenitors & NEUN neurons in mouse cortex. Inspired by: Spatial Proteomics Reveals Distinct Protein Patterns in Cortical Migration Disorders Caused by LIN28A Overexpression and WNT Activation: mcponline.org/article/S1535-….
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ALT This is an immunofluorescent image of the cerebral cortex, showing the progenitor marker SOX2 and the mature neuron marker NEUN. The image illustrates the process by which the nanosecond infrared laser ablates the brain tissue and dissolves the proteins into an aerosol. Each sample has a unique protein composition projected as dots in a UMAP. By Jelena Navolic and Julia Neumann.
Our latest study @molcellprot uncovers a hidden crosslinking chemistry of lipid peroxidation! We show that an endogenous aldehyde crosslinks vicinal cysteine–lysine pairs in cellular proteins via Michael addition and Paal-Knorr condensation. #LipidPeroxidation#Crosslinking
🧠 Via @MolCellProt:
Researchers at @WinshipAtEmory have developed a new proximity-labeling method to identify the proteins that interact with tau during aggregation, uncovering hundreds of tau-associated proteins linked to neurodegenerative disease.
asbmb.org/asbmb-today/scienc…
New in MCP press| N-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function.
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ALT Figure 4 | Spectra of identified glycosylated peptides Representative spectra showing glycopeptide and glycan fragmentation patterns of AXL glycosylation sites N43 (A), N157 (B), N198 (C) and N345 (D).
New in MCP Press| Scientists present MsTargetPeaker, a quality-aware search procedure for identifying peak regions in targeted proteomics data.
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mcponline.org/article/S1535-…#asbmbMCP
ALT Figure 7 .Usage workflow of MsTargetPeaker and diagnostic reports.
🌍 Join #MolCellProt in celebrating the International Day of Women and Girls in Science!
Women in Proteomics, a new MCP special issue, showcases women driving innovation and discovery in proteome research.
➡️ Read more: mcponline.org/women-in-prote…
🎨 Luciana Giono
ALT Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.
This special issue of Molecular and Cellular Proteomics spotlights the leadership and achievements of women in proteomics, celebrating their scientific excellence, innovation, and transformative impact on the field.
mcponline.org/women-in-prote…#molcellprot
New in MCP Press| Circulating extracellular vesicle protein biomarkers for the early detection of high-grade serous ovarian cancer.
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ALT Figure 7. Development of a combinatorial exo-protein diagnostic biomarker panel and assessment of MUC1 exo-protein in plasma-derived EVs.
#WorldCancerDay research spotlight: "High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen" by Vanarsa, Kamala et al.
➡️Access the #MolCellProt paper: mcponline.org/article/S1535-…
ALT Antibody array-based proteomic screening of colorectal cancer stool and graphical representation of significantly different proteins in CRC vs HC.
#WorldCancerDay | Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies.
➡️ Read about this recent article published in Molecular & Cellular Proteomics: asbmb.org/asbmb-today/scienc…
In this special issue of Molecular and Cellular Proteomics, we wish to recognize and celebrate the career achievements of Professor Donald Frederick Hunt upon his retirement after 60 years in science.
mcponline.org/special-issue-…#molcellprot
New in MCP press| Scientists observe that proteins selected based on their measurement robustness are still able to capture differences in abundance across disease groups in a small sample set.
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ALT Figure 2. CSF survey PRM assays developed from either Stellar MS linear ion trap (LIT) GPF library or Orbitrap™ (OT) GPF library data.
New in MCP press| plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy
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mcponline.org/article/S1535-…#molcellprot
ALT Figure 2. Differential protein abundance analysis of plasma samples across irAE groups.
New in MCP press| Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.
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ALT Figure 1. Tandem duplications within exon 3 of AKT1 in JGCTs used in this study.
A recent study explores how extracellular vesicles (EVs) in the maternal environment impact embryo development in cattle. By analyzing EVs from pregnant heifers, they're unlocking insights to improve bovine reproductive efficiency: asbmb.org/asbmb-today/scienc…@ASBMB@molcellprot
Check out our latestwork‼️
"Omics and Multiomics-Based Diagnostics for Invasive Candidiasis: Toward Precision Medicine" in @molcellprot
📝The paper looks at how omics technologies can be used to develop biomarkers in IC
Congratulations @VictorArribs
👇👇
sciencedirect.com/science/ar…
Extracellular vesicles from pregnant cattle support embryo development better than laboratory models, highlighting their potential to improve reproductive efficiency in bovine embryo cultures.
➡️Read more about this recent @MolCellProt paper: ow.ly/imbu50Xvv33.