A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
Joined March 2009
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Our June issue is live with a focus on RNA chemical biology
nature.com/nchembio/volumes/…
The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
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Structures of telomerase with allosteric inhibitor BIBR1532 reveal an unexpected mode of inhibition and unique insights into telomerase mechanism
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Glucose deprivation promotes OXCT1 phosphorylation and nuclear translocation, which leads to repressed transcription of MHC-I and chemokine genes and reduced immunotherapy responsiveness
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Cystine C-S bond cleavage fuels cysteine production under disulfide reductase deficiency
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Generation of membrane-permeable cyclic peptides inhibiting protein-protein interaction
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Oxygen-dependent and photoreactive APEX2-based proximity labeling using a chemically evolved biotin probe for applications in living cells and in vivo
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A new Review on using large-scale glycomics to understand glycan function #glycotime
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A new Perspective details the current bottlenecks and outlines a research roadmap in biocatalytic nylon recycling
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The editorial highlights RNA breakthroughs in this issue
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and a Q&A with Maria Duca, Samie Jaffrey, and Ling-Ling Chen discusses challenges and opportunities in RNA-centered therapeutics
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Our June issue is live with a focus on RNA chemical biology
nature.com/nchembio/volumes/…
The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
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Nature Chemical Biology retweeted
May 28
Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors rdcu.be/flcIs
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A genetically encoded peptide inhibitor of mTORC1 is developed and reveals that nuclear mTORC1 regulates a specific set of genes and promotes cancer cell proliferation
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The potency of a class of RAF kinase inhibitors is found to depend on cancer cell signaling activity, and MEK inhibitors can be reengineered to sensitize RAF kinases to inhibitors for synergistic RAF-MEK inhibitor combinations
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A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference
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A new platform screens for and enables the design of peptide biosensors of dysregulated proteolytic activity in tumors for tumor detection and therapeutic development
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A bioorthogonal, clickable dopamine probe enables chemoproteomic mapping of dopaminylated proteins, revealing a role for histone H4 dopaminylation in cell growth
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Nature Chemical Biology retweeted
Happy to share the final version of this work is now out in @nchembio. Lots of additional exciting data! Congrats to all the authors!
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3 Aug 2025
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews. biorxiv.org/content/10.1101/…
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Our May issue is live!
nature.com/nchembio/volumes/…
The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites
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A new Perspective discusses recent developments in RNA modifications on chromatin-associated RNAs, how they modulate chromatin states, and future direction for studying RNA regulatory elements to control gene expression
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A condensation-independent intramodular translocation mechanism in trans-acyltransferase polyketide synthases
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A cell-permeable nanobody stabilizes misfolded F508del cystic fibrosis transmembrane conductance regulator (CFTR) and restores CFTR activity
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