Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.
Joined December 2018
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62 Photos and videos
Jun 5
Our study demonstrated that IRF4 can be chemically targeted. Our approach can be further developed into novel therapy for multiple myeloma.
nature.com/articles/s41589-0…
Please support our drug discovery effort for high risk tagets @JunQiLab at @DanaFarber. danafarber.jimmyfund.org/sit…
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May 28
Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors rdcu.be/flcIs
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Mar 8
Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. molecularmetabolism.com/arti…
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Feb 24
Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks
Hope is powerful. Research is lifesaving. 🙏
Your support helps fund groundbreaking discoveries for children battling cancer.
Read how it’s making a difference in our latest edition of Research Outcomes: ow.ly/sNel50YhTUk
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Jan 23
With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.
Jan 23
New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs.
➡️ bit.ly/4rbilu9
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Jan 23
It was such a fun day to visit @PennMedicine and talk about science with @junwei_s @LilingWanLab and present our science. Thank you for having me.
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Jan 20
Our work using cap region proteins of proteosome to directly induce targeted protein degradation is now published online @angew_chem. Congratulations to all the authors on bringing this to the finish line. Thanks @BloodCancerUtd for supporting our work.
doi.org/10.1002/anie.2025200…
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4 Dec 2025
We would like to thank the support from @EpendymomaRF, @curingkidsckc and @StBaldricks that allow us to build our biology capability to explore novel therapeutic options for pediatric brain cancer.
3 Dec 2025
Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/jac…
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3 Dec 2025
I am thrilled to work and publish together with my postdoc PI, Prof. Mo Movassaghi @ChemistryMIT to bring their sophisticated chemistry to potential therapy development. I am excited to keep learning from Mo and @FilbinMariella. Pic from: news.mit.edu
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3 Dec 2025
Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/jac…
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21 Nov 2025
This is absolutely fun!!! @LabSethi cannot wait to do more together. To create more and better understanding in cancers and find potential novel therapy together. @AGA_Gastro
Can we have a biotinylated and inactive version of the HDAC1/2 inhibitor? How do you do Chem-seq, Jun? In the end, we were able to follow our observations and publish these findings thanks to collaborative science fostered by @DanaFarber @DanaFarberNews
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20 Nov 2025
It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. authors.elsevier.com/c/1m7oK…
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19 Jul 2025
It is so exciting to see our collaborative work with @Nilay_Sethi is now available online. My team and I are always eager to learn more about novel therapy development for CRC together with Nilay and his wonderful team!!!
18 Jul 2025
Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study: bit.ly/46gS7z1
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14 Apr 2025
It is awesome to have JQ-WON team to build a boat and get first place in the boat building competition at @DFCI_ChemBio retreat!!!! Awesome design, decoration, ride, and teamwork!
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26 Mar 2025
It is so great to have @LilingWanLab to visit us and give a great seminar.
25 Mar 2025
Had a great time visiting Dana-Farber Cancer Institute and sharing our work on chromatin mechanisms in cancer! Huge thanks to @JunQiLab for the invitation and generous hosting. So much fun reconnecting with mentor & old friends, making new ones, & a full day of amazing science!
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5 Mar 2025
Congratulations to all of our friends, collaborators, and colleagues!!! @FilbinMariella @Nilay_Sethi @Oser_Lab @srviswanathan
4 Mar 2025
Dana-Farber has elected the largest cohort of physician-investigators to the 2025 class of ASCI
@DanaFarber @FilbinMariella @ManciasLab @Oser_Lab @AbbyRosenbergMD @Nilay_Sethi @srviswanathan
oncodaily.com/blog/dana-farb…
#ASCI #Cancer #OncoDaily #Medicine #Oncology #MedEd #MedX #MedNews
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30 Jan 2025
It is so exciting to receive the Curing Kids Cancer Research Award from @curingcancer together with our dearest collaborators, @ADurbinLab @RousselMartine! Thank you for supporting our work to develop a novel therapeutic strategy for medulloblastoma!
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19 Dec 2024
It is great to celebrate this holiday season with a group of hardworking and self motivated lab members. Thank you for making the science so much fun. I am excited to work with you more in 2025. Happy holidays, Qi lab!!!!!
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18 Dec 2024
It is also exciting to see that the Chem-Seq works so well with HDAC1/2 with @Nilay_Sethi and @LabSethi after the development on Chem-Seq of BET bromodomain @jaybradner.
biorxiv.org/content/10.1101/…. Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer. By screening drugs using a new reporter system, we found that inhibiting HDAC1/2 promotes colorectal cancer (CRC) differentiation and anti-tumor activity
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18 Dec 2024
It is exciting to work with @LabSethi and whole team on this project to reveal more mechanisms on CRC differentiation.
biorxiv.org/content/10.1101/…. Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer. By screening drugs using a new reporter system, we found that inhibiting HDAC1/2 promotes colorectal cancer (CRC) differentiation and anti-tumor activity
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