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Narayan Lab @ UMich @NarayanLab

Biocatalysis and complex molecule synthesis at the University of Michigan. Go BLUE! Go Chemistry! Now on bluesky @narayanlab.bsky.social

Joined February 2016
  • Tweets 1,589
  • Following 805
  • Followers 6,916
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Narayan Lab @ UMich@NarayanLab
Feb 6
Check out our synthesis of enantioenriched atropisomers in Nature! rdcu.be/e2Kc0
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Phenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer | Analytical Chemistry pubs.acs.org/doi/10.1021/acs…

Phenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer

Biotechnology is increasingly relying on high-throughput experiments in which large populations of cells are phenotyped and selected based on performance, e.g., for producing a desired product....

pubs.acs.org
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A round of applause for the amazing Dr. José!!! The P450 and non-heme king is moving on and we are so excited to watch you succeed!!! 👑 #GoBlue #Biocats
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CATNIP for the win! Read our newest work with the Gomes group- doi.org/10.1038/s41586-025-0… @Apatoneh @gabepgomes @daniil_boiko @AlisonNarayanUM
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Read our newest collaboration with the Hartwig group: Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade

Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and...

pubs.acs.org
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Ancestral Sequence Reconstruction to Accelerate Non-heme Iron-dependent Biocatalyst Engineering | ACS Central Science pubs.acs.org/doi/10.1021/acs…

Ancestral Sequence Reconstruction to Accelerate Non-heme Iron-dependent Biocatalyst Engineering

Nature provides access to biological catalysts that can expand the chemical transformations accessible to synthetic chemists. Among these, α-ketoglutarate, non-heme iron-dependent (NHI) enzymes stand...

pubs.acs.org
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Uncovering the Origins of Selectivity in Non-Heme Iron Dioxygenase-Catalyzed Tropolone Biosynthesis | The Journal of Physical Chemistry B pubs.acs.org/doi/10.1021/acs…

Uncovering the Origins of Selectivity in Non-Heme Iron Dioxygenase-Catalyzed Tropolone Biosynthesis

Non-heme iron (NHI) enzymes perform diverse oxidative transformations with precise control, which can be challenging to achieve with small molecule catalysts, such as the biosynthesis of tropolone....

pubs.acs.org
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Profiling of Diverse Pyridoxal-5′-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Profiling of Diverse Pyridoxal-5′-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity...

The elaboration of amine substrates through C–C bond-forming reactions is important in the synthesis of bioactive small molecules. Pyridoxal-5′-phosphate (PLP)-dependent enzymes have emerged as...

pubs.acs.org
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Narayan Lab @ UMich retweeted
UMLifeSciences
@UMLifeSciences
1 Oct 2025
A team from @UMich and @CarnegieMellon has developed CATNIP for chemists — a data-driven platform that removes a major barrier to wider adoption of #biocatalysis, making greener chemistry more accessible. Read more: myumi.ch/dgp2Z
Abstract representation of the connections between chemical space and protein space

ALT Abstract representation of the connections between chemical space and protein space
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Congrats to our newest doctor @AtsauSaucedo !!! so proud of our tropolone king 👑 #GoBlue #Biocats
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The Narayan birthday elves struck again! Happy 16th birthday Alison! 🥳 #Sweet16 #Biocats #GoBlue
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Ryan passed his candidacy exam! PLP for the win 🤩 #Biocat #GoBlue
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Narayan Lab @ UMich retweeted
Allie Paton, PhD@Apatoneh
14 Apr 2025
I’m thrilled to share that I will be joining the Department of Chemistry at the University of Rochester as an Assistant Professor! So thankful for this opportunity and excited about expanding the field of biocatalytic synthesis!
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Yesterday our PLP queen became a PhD candidate! Congratulations Maddie on a fantastic gateway exam! #PLP #Biocats #GoBlue
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Congratulations to our new PhD candidate Caroline! The Mapp and Narayan labs are so proud of you! #Biocat #GoBlue
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Calling everyone interested in learning biocatalysis! Come to the Narayan lab to learn the biocat basics. Please apply here - docs.google.com/forms/d/e/1F… #Biocat #GoBlue
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Today is the last day to apply! #Biocat #GoBlue
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The application deadline has been extended to April 11th! For more information on the workshop look here - sites.google.com/umich.edu/c…
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Narayan Lab @ UMich retweeted
Gabe Gomes
@gabepgomes
28 Mar 2025
CATNIP – our collaboration with the @NarayanLab under the NSF Center for Chemoenzymatic Synthesis – was nicely covered on @cenmag! one of the coolest works we’ve been involved in, headed by the one and only @daniil_boiko on our side. cen.acs.org/acs-news/acs-mee…

Chemists create matchmaking app for biocatalysis

Machine learning model Catnip helps chemists find biocatalysts to try in synthesis

cen.acs.org
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Go Eunjae go!!
Zimmerman Group@ZimmermanUMich
26 Feb 2025
Check out our latest article by @EunjaeShim1 now published in @ChemicalScience on label ranking, introduced as an efficient #MachineLearning algorithm to predict high yielding and effective reaction conditions for a variety of substrates. pubs.rsc.org/en/content/arti…
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