Joined January 2022
- Tweets 4,675
- Following 425
- Followers 539
- Likes 103
2,901 Photos and videos
All roads lead to Rome.
Different starting points, different paths
Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, ¬ just HLA problem
48
Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, ¬ just HLA problem
May 13
Cancer type-specific variation in patterns of driver alterations across 50,000 tumors dlvr.it/TSWtCg
67
Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, ¬ just HLA problem
@Cancer_Cell
Cancer type-specific variation in patterns of driver alterations across 50,000 tumors cell.com/cancer-cell/fulltex…
1
21
All roads lead to Rome.
Different starting points, different roads.
@Cancer_Cell
Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent
@Cancer_Cell
cell.com/cancer-cell/fulltex…
1
3
6
514
Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent
@Cancer_Cell
cell.com/cancer-cell/fulltex…
538
Jun 13
ddx6 and adar1 are mainly embryonic neural
The RNA helicase DDX6 promotes immunosuppression in #cancer by repressing ADAR1-mediated #dsRNA stabilization, preventing interferon activation. Learn more in Science #Immunology: scim.ag/4eeZDga
1
71
Jun 13
Understanding
cancer cell/immunoevasion
&cancer complexity
&cancer therapy
&even the inverse correlation between cancer and Alzheimer's
...
as a whole
by understanding neural stemness as the core property of cancer cell
&rules dictated by neural stemness.
preprints.org/manuscript/202…
Jun 13
When you talk about cancer stem cells or cancer stemness, what are you talking about?
Tissue stemness, ESC stemness, other stemness or nothing comparable?
Understanding neural stemness as the core property of cancer cells and its role in immunoevasion @Cancer_Cell
18
Jun 13
When you talk about cancer stem cells or cancer stemness, what are you talking about?
Tissue stemness, ESC stemness, other stemness or nothing comparable?
Understanding neural stemness as the core property of cancer cells and its role in immunoevasion @Cancer_Cell
Jun 11
Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways dlvr.it/TT0Hqm
29
Jun 13
The EMT community still cannot face EMT's essential flaws directly
They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs
link.springer.com/article/10…
Jun 13
The impact of EMT is profound.
It has established very strong&solid conditioned reflexes.
Once symbols like vim/cdh2...are heard/seen, the tempting but mythic EMT immediately comes to mind, and just can't stop the urge to explore EMT
@Cancer_Cell
cell.com/cancer-cell/fulltex…
15
Jun 13
The impact of EMT is profound.
It has established very strong&solid conditioned reflexes.
Once symbols like vim/cdh2...are heard/seen, the tempting but mythic EMT immediately comes to mind, and just can't stop the urge to explore EMT @Cancer_Cell
Jun 10
A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma dlvr.it/TSzKxk
2
48
Jun 13
When the question 'why cancer is so hard to treat' is seriously discussed🫣🤭
9
Jun 13
The EMT community still cannot face EMT's essential flaws directly
They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs
link.springer.com/article/10…
18
Jun 13
The impact of EMT is profound.
It has established very strong&solid conditioned reflexes.
Once symbols like vim/cdh2...are heard/seen, the tempting but mythic EMT immediately comes to mind, and just can't stop the urge to explore EMT
@Cancer_Cell
cell.com/cancer-cell/fulltex…
31
Jun 13
When the question 'why cancer is so hard to treat' is seriously discussed
Jun 13
You don't even know what is EMT, but you know EMT states in cancer. @Nature
nature.com/articles/s41588-0…
25
Jun 13
The EMT community still cannot face EMT's essential flaws directly
They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs
link.springer.com/article/10…
Jun 13
You don't even know what is EMT, but you know EMT states in cancer. @Nature
nature.com/articles/s41588-0…
27
Jun 13
You don't even know what is EMT, but you know EMT states in cancer. @Nature
nature.com/articles/s41588-0…
90
Jun 13
The EMT community still cannot face EMT's essential flaws directly
They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs
link.springer.com/article/10…
Jun 13
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT&how it can be helpful.
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
link.springer.com/article/10…
18
Jun 13
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT&how it can be helpful.
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
link.springer.com/article/10…
Jun 12
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency: Cell cell.com/cell/fulltext/S0092…
48
Jun 13
The impact of EMT is profound. It has established very strong&solid conditioned reflexes.
Once symbols like snai1/cdh2...are heard/seen, the tempting but mythic EMT immediately comes to mind, and just can't stop the urge to explore EMT.
Jun 12
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency: Cell cell.com/cell/fulltext/S0092…
31