A daily word-guessing game. Final answers are all related to neurology or neuroscience. Be careful... proper nouns, plurals, and abbreviations are fair game!
Joined April 2023
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Neurdle 1000!
Thank you to everyone who has stuck with us and our educational neurology games for 1000 days!
Join the creators of Neurdle in game development through GANGLIA: neurdgames.com/ganglia
Jan 12
Neurdle 1000 5/6
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6 Nov 2025
Neurdle, November 5th, 2025:
A cytotoxic lesion of the corpus callosum (CLOCC; also called MERS, mild encephalopathy with reversable splenial lesion) can come from many different etiologies related to infection, inflammation and medication...cont. below
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7 Nov 2025
COVID19 can cause this, and other types of brain inflammation, as reviewed here: pubmed.ncbi.nlm.nih.gov/3400…
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30 Oct 2025
Neurdle, October 29th, 2025:
What's scarier than a brain-eating fungus? Absolutely nothing - that's why I'm working on a script for a horror movie called "The Fungus that Ate My Brain," and I'm using this review to help keep it believable: ncbi.nlm.nih.gov/pmc/article…
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29 Oct 2025
Neurdle, October 28th, 2025:
Oooooh, a skull - so creepy, so Halloweeny, so normal for housing the brain! Early fusing of sutures leads to a skull deformity called craniosynostosis - a major problem that prevents brain growth...cont. below
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29 Oct 2025
that has to be distinguished clinically from the very common and completely benign positional plagiocephaly (when a baby has a kind of flat head, but the brain still grows normally). Read how to distinguish the two here: journals.healio.com/doi/full…
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28 Oct 2025
Neurdle, October 27th, 2025:
Happy almost Halloween! Many of us will be eating a lot of sugar this week (why yes, it does increase your risk for dementia - but so does everything else, so why don't you live a little...cont. below:
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28 Oct 2025
pmc.ncbi.nlm.nih.gov/article…) so let's celebrate the sugar pill - the placebo. The placebo effect is remarkable in studies of pain, headache, sleep, depression - but also in seizures and dementia (phew! glad I found an antidote to this peanut butter cup).
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28 Oct 2025
Here's a paper on the neuroscience of the placebo effect: ncbi.nlm.nih.gov/pmc/article…
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27 Oct 2025
Neurdle, October 26th, 2025:
Happy almost Halloween! CASPR2 is not a friendly ghost - it's a cell-adhesion molecule that is important for localization of voltage-gated potassium channels...cont. below
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27 Oct 2025
Antibodies to CASPR2 causes an autoimmune encephalitis with a wide spectrum of symptoms (oooh, scary!): ncbi.nlm.nih.gov/pmc/article…
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25 Oct 2025
Neurdle, October 24, 2025:
Multiple sclerosis is diagnosed by a separation of demyelinating events in space and time; so it can theoretically be diagnosed clinically, without imaging; but check out all the other elements you CAN use for diagnosis in the new...cont. below:
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26 Oct 2025
2024 McDonald criteria, intended to increase sensitivity and specificity thelancet.com/journals/laneu… (paywalled).
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26 Oct 2025
But whatever, neuroimmunologists are everywhere. Have you ever considered being a neurologist...IN SPACE? nature.com/articles/s41598-0…
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2 Oct 2025
Neurdle, October 1st, 2025:
Don't get caught in the autonomic storm! Paroxysmal sympathetic hyperactivity can occur after severe traumatic brain injury (frontiersin.org/articles/10.…)...cont. below
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2 Oct 2025
or in the setting of NMDA-receptor antibody-positive encephalitis (frontiersin.org/articles/10.…) with tachycardia, tachypnea, fever and dystonia.
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1 Oct 2025
Neurdle, September 30th, 2025:
Now Twitter is "X" and tweeting is "posting" and the world is difficult, but we still need to figure out a way to communicate neurology ideas with other neurologists and the general public...cont. below
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1 Oct 2025
The Neurology Digital Education Collaborative (ndec.institute) created by Jacki Martindale and Jess Goldstein is a great way to learn how to navigate changes in social media - and teach through online tutorials, podcasts, videos, blogs and more. Consider applying!
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30 Sep 2025
Neurdle, September 29th, 2025:
The word "neuroprotective" activates my BS detector, but the noble gas xenon has been explored for years in anesthesia...cont. below:
minervamedica.it/en/journals…
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30 Sep 2025
as an adjuvant to cooling in neonatal hypoxic ischemic encephalopathy cochranelibrary.com/cdsr/doi… and may help people climb really high mountains faster nejm.org/doi/full/10.1056/NE…
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