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Kevin OConnor @OConnorLabYale

The O’Connor Lab at Yale studies B cells in neuro-autoimmune diseases (MG, NMOSD, MOGAD) to dautoreactive B cells and antibodies drive nervous system autoimmuni

Joined October 2025
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Gianvito Masi@GianvitoMasi
29 Oct 2025
Replying to @OConnorLabYale
@OConnorLabYale and I are thrilled to share that our new study on MuSK myasthenia gravis (MG) has just been published in @Brain1878 !👇 (1/8) doi.org/10.1093/brain/awaf41…

IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology

MuSK myasthenia gravis is an autoimmune disease in which IgG4 antibodies disrupt nerve–muscle communication, causing severe weakness. Masi et al. show that

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Excited to share new findings from the O’Connor Lab at Yale & @SeismicTherap: IgM autoantibodies can drive MG in some patients. Pairing S-1117 with an IgM-targeting enzyme fully blocked harmful antibodies → step toward personalized MG therapy. pnas.org/doi/abs/10.1073/pna…

Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that...

Myasthenia gravis (MG) is an autoimmune disorder caused mainly by autoantibodies against the acetylcholine receptor (AChR), leading to muscle weakn...

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