Joined February 2021
- Tweets 20
- Following 22
- Followers 68
- Likes 1
9 Photos and videos
Pinned Tweet
20 Sep 2022
Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 authors.elsevier.com/a/1fnZ7…
3
15
41
🚨 Proud to share our new study in @CellPressNews: B cells producing auto-Abs that neutralize type I IFNs in severe viral infections. Work from AI2B_lab @NeckerInem, @casanova_lab, @GorochovG and Rey’s labs @institutpasteur. doi.org/10.1016/j.cell.2026.…
4
39
114
46,014
Our data support a model where T-cell tolerance breakdown drives a germinal center B-cell response against type I IFNs, months to years before severe viral infection.
1
1
11
422
This silent autoimmune state, revealed upon viral infection, may affect ~0.4% (<70 yrs) to 4% (>70 yrs) of the population and represents a common and global determinant of severe viral disease.
1
6
19
589
Pascal Chappert retweeted
7 Aug 2023
Online now: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals dlvr.it/StKFk6
22
46
6,990
Des scientifiques ont découvert comment l'infection par le variant #Omicron BA.1 remodèle la mémoire immunitaire chez des patients vaccinés, améliorant ainsi les capacités des cellules mémoires à reconnaître le #SARSCOV2 et à le neutraliser.⤵️
presse.inserm.fr/linfection-…
2
21
48
10,153
Pascal Chappert retweeted
Une équipe de recherche a analysé la mémoire immunitaire après infection par le variant Omicron BA.1 chez des patients vaccinés avec trois doses du vaccin COVID-19 à ARN messager.
aphp.fr/contenu/linfection-p…
5
12
32
7,364
Pascal Chappert retweeted
4 Aug 2023
🔬Our new article is now online at @ImmunityCP ! We analyzed how memory B cell repertoire is remodeled by Omicron breakthrough infection💉🦠🧫! Great collaborative work! @NeckerInem @institutpasteur @APHP @IMRB_Mondor @PChappert @MahevasMatthieu cell.com/immunity/fulltext/S… 👇🧵
1
16
36
10,102
20 Sep 2022
Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 authors.elsevier.com/a/1fnZ7…
3
15
41
20 Sep 2022
Instead, these long-lived MBCs appeared enriched in a CD21hiCD20hi IgG splenic B cell subset displaying a marginal zone-like NOTCH/MYC-driven signature and harbored long-lasting elongated telomeres.
2
1
20 Sep 2022
Overall, our results imply that separate mechanisms such as early telomere elongation, affinity selection during the contraction phase and access to a specific niche contribute to ensuring the functional longevity of MBCs.
2
Pascal Chappert retweeted
18 Jun 2021
Diversity is the key! Our new pre-print shows that the diversity of their repertoire allows memory B cells to control SARS-CoV-2 variants. Thanks to all for this collaborative study! @NeckerInem @institutpasteur @IMRB_Mondor biorxiv.org/content/10.1101/…
1
3
10