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Perrimon Lab @PerrimonLab

Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.

Joined December 2017
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  • Followers 4,435
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New paper: Streptomyces produce a diphtheria toxin-like exotoxin that targets insects. Xu et al.Nat Microbiol. 2026 Apr 30. doi: 10.1038/s41564-026-02315-5. Online ahead of print. PMID: 42062574
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New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678
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Miao, T., Liu, Y., Qadiri, M., Dasseux, A., Asara, J. M., Hu, Y., Sun, X., Pliego-Alcántara, LDC., Dibble, C. and Perrimon, N. (2026) Renal coenzyme A (CoA) production from Vitamin B5 fuels stem cell proliferation and tumor growth. Nat Commun. doi: 10.1038/s41467-026-71716-1.
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hms.harvard.edu/news/not-wan…

Not Wanting To Eat Protein May Be Early Herald of Cancer Cachexia

Study in fruit flies uncovers earliest known sign of impending muscle and fat wasting

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Han. M., Xia, B., Kim, A-R., Filine, E., Stoneburner, E., Miao, T., Liu, Y., Zirin, J. and Perrimon, N. (2026) Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila. PNAS. 14;123(15):e2531777123. doi: 10.1073/pnas.2531777123. PMID: 41941621
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Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134
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Lane, E., Petsakou, A., Liu, Y., Chen, W., Qadiri, M., Hu, Y. and Perrimon, N. (2026) Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis. PloS Genetics. 22(2):e1012048. doi: 10.1371/journal.pgen.1012048. PMID: 41701793
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Ewen-Campen, B., Chen, W., Tattikota, S. G., Liu, Y., Hu, Y. and Perrimon, N. (2026) The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth. doi: doi.org/10.1101/2025.06.27.6…. Nat Comm. PMID: 41593082
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Moon, Hu, Dzieciatkowska, Kim, Asara, D'Alessandro and Perrimon (2026) Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels. Nat Comm. doi: 10.1038/s41467-026-68395-3.
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Marques et al. (2025) In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila. eLife14:RP109422https://doi.org/10.7554/eLife.109422.1
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Lin, Deng, Gao, Tan, Zhong, Tan, Tan, Virshup, Bosch, Perrimon and Wang (2026) Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila. Nat. Comm. doi: 10.1038/s41467-025-66727-3. PMID: 41298547
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Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu., Y., Mohr, Perrimon and Smith (2025) A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes. 16(1):10323. doi: 10.1038/s41467-025-65304-y. PMID: 41285753
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Huang, K. and Perrimon, N. (2025) Metabolic command centers in Drosophila: How the fat body and oenocytes orchestrate immunity, reproduction, and aging. Current Opinion in Insect Science. 101459. doi: 10.1016/j.cois.2025.101459. PMID: 41218693
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New paper Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila Han, Xia, Ah-Ram Kim, Filine, Stoneburner, Miao, Liu, Zirin, Perrimon bioRxiv 2025.10.31.685841; doi: doi.org/10.1101/2025.10.31.6…
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New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon bioRxiv 2025.10.10.681672; doi: doi.org/10.1101/2025.10.10.6…
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New paper: A family of lethal exotoxins defined by cell entry via the Attractin receptor Viswanatha, Lee, Robins, Mameli, Hu, Kim, Hashmi, Hiroshi , Prakash, Butnaru, Churchman, Mohr, Mekalanos, Perrimon doi: doi.org/10.1101/2025.10.08.6…
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New paper: Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer Liu, Miao, Wang, Ezequiel, Kim, Zhang, Sun, Binari, Asara, Hu, Goncalves, Janowitz, Perrimon doi: doi.org/10.1101/2025.10.01.6…
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thecrimson.com/article/2025/… Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News |...

Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson

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A Better Way to Treat Obesity

PhD student Muhammad Ahmad has pinpointed important genes that regulate the retention and burning of fat in fruit flies and mammalian cells. His goal? To develop gene-editing therapies that could be...

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