Genome Integrity Lab | Assistant Professor @CRI_UTSW @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange in cancer genomes.
Joined October 2018
- Tweets 2,333
- Following 611
- Followers 2,363
- Likes 7,925
102 Photos and videos
Pinned Tweet
May 19
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/S0092…
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Peter Ly retweeted
Jun 11
Why 50% of human fertilized eggs fail to complete pre-implantation development?
Latest work from my lab in @CellCellPress now clarifies the two causes that contribute to the low efficiency of early human embryos and provides one of the solutions. (1/7)
doi.org/10.1016/j.cell.2026.…
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Peter Ly retweeted
Jun 12
Now online: Seeing is Believing: Intercellular Transfer of DNA between human cells doi.org/10.1158/0008-5472.CA…
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Peter Ly retweeted
Very excited to be sharing our new paper, just out in Nature Cell Biology! nature.com/articles/s41556-0…
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Peter Ly retweeted
Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, @vaitsiankova, and Tomas Lama-Diaz!
biorxiv.org/cgi/content/shor…
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Peter Ly retweeted
Thrilled to have contributed to this beautiful work from the O'Sullivan lab, now out @Nature! nature.com/articles/s41586-0…🧬 @ginibh31 @MahlkeMegan @KarlsederLab @UPMCHillmanCC
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Jun 1
The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏
Full posting: cri.utsw.edu/careers/
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Peter Ly retweeted
May 29
Learn how DNA can be exchanged between two cells that connect by forming nanotubes, and find out why this is crucial for cancer research. discovermagazine.com/human-c…
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May 29
Proud milestone for our lab. Congrats to our first two graduate students, Lizz Maurais, PhD, and Justin Engel, PhD! @UTSWGradSchool
We also celebrated Lizz’s last day as she moves on to an exciting new adventure @biogen. Good luck Lizz!
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Peter Ly retweeted
May 28
🧬 ⛓️💥 Our paper is now out in @NatureSMB! We examined the fate of replication forks that collapse at single-strand DNA breaks (SSBs) in vertebrates 🐸, comparing the consequences of collapse at single vs convergent forks. nature.com/articles/s41594-0…
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Peter Ly retweeted
May 23
Until now, no one had seen DNA voyaging between human cells along intercellular highways called tunneling nanotubes.
sciencenews.org/article/dama…
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Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research…
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Peter Ly retweeted
May 22
Now online! Genome instability triggers intercellular DNA transfer between human cells dlvr.it/TSgLb5
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Peter Ly retweeted
May 22
Telomere crisis is an engine of genomic instability, driving the structural evolution of cancer genomes. Our new preprint finds this damage isn't random: it converges on the nucleolus and the chromosomes that build it. 🧵
biorxiv.org/content/10.64898…
ALT Two multicolor FISH karyograms of telomere-crisis NHA cells. Each chromosome is painted a distinct color and arranged in karyotype order, with extra marker chromosomes below. Labels point to numerous abnormalities, including several translocations and deletions; chromosome 13 is deleted in both cells.
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May 20
Had a fun conversation with @ScienceNews about our recent findings. Thanks for covering our work!
May 19
Like prisoners tunneling out of jail, damaged DNA travels via tubelike structures between neighboring cells.
sciencenews.org/article/dama…
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Peter Ly retweeted
ONLINE NOW in @CellCellPress: @PeterLyLab has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. Read more about this #relentlessdiscovery ⬇️ cri.utsw.edu/human-cells-can…
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Peter Ly retweeted
ONLINE NOW in @CellCellPress: @PeterLyLab has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. Read more about this #relentlessdiscovery ⬇️ cri.utsw.edu/human-cells-can…
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May 19
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/S0092…
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May 19
Many questions remain. We now aim to define the prevalence, mechanisms, and biological impact of intercellular DNA transfer across physiological and disease contexts.
🚨 We are recruiting #postdocs to lead these efforts – please reach out if interested! (6/7)
@UTSWPostdocs
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May 19
Congrats to grad student Lizz Maurais, who drove this project with relentless resilience alongside a remarkable team of lab members and collaborators! (7/7)
@CRI_UTSW @UTSWMedCenter @UTSWGradSchool
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