Developing mass spectrometry and chemical biology tools to study dynamic protein interactions at @VanderbiltChem. This is a trainee run account.
Joined March 2019
- Tweets 144
- Following 224
- Followers 319
- Likes 105
65 Photos and videos
5 Jun 2024
Excited to share a preprint from @J_P_Davies PhD work! We find that CoVs, like SARS-CoV-2, use malectin (part of cells’ glycoprotein production assembly line) to make viral proteins and replicate. Malectin may be a prime pan-CoV antiviral target! 🧵(1/7)
biorxiv.org/content/10.1101/…
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5 Jun 2024
MLEC surveys our glycoproteins during production, checking for errors and capturing duds before they are sent out. Is this function of MLEC important for CoV replication? Yes! (6/7)
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5 Jun 2024
Lastly, is MLEC important for SARS-CoV-2 replication? We use a replicon system to show that YES, it is! (7/7)
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10 Nov 2023
Congratulations @EliFritzMcD !
Congratulations to @EliFritzMcD (of the @MeilerLab & @Plate_Lab) on winning the 2024 Karpay Award in Structural Biology! Eli presents "CFTR Folding – Started from the Translocon Now We Here" on Tuesday, January 23, 2024, for the MBTP/CSB Seminar Series.
bit.ly/3ufN00S
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2 Nov 2023
Good morning Phoenix. Looking forward to attending #NACFC2023. If you’re around, come to the lunch roundtable on Proteomic-driven Advances in Studies of CF (RT29) where we’ll discuss the latest mass spec research on CF. @CF_Foundation
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9 Oct 2023
Can #AlphaMissense identify Cystic Fibrosis causing variants?
We benchmarked AM pathogenicity predictions on CF clinical outcomes from the CFTR2.org database and CFTR in vitro data. @EliFritzMcD @MeilerLab
Here's what we found: 🧵(1/7)
biorxiv.org/content/10.1101/…
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9 Oct 2023
Finally, we were curious if AM could predict CFTR theratype - how CFTR variants respond to drug.
This feat is technically outside AM's intended design, but is important in the CF field.
We concluded, AM cannot predict CFTR theratype. (6/7)
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9 Oct 2023
In sum, AM predicts CF accurately w/ a high false positive rate.
AM correlated modestly w/ clinical outcomes, but well w/ CFTR function. It cannot distinguish pathophysiology.
AM may prove useful for identifying CF causing variants in carriers, but caution must be taken.
(7/7)
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19 Sep 2023
Congrats @Dongsheng_Han1 and @JaredNordman! Glad that @J_P_Davies and our lab could contribute to this exciting paper.
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14 Sep 2023
Follow @J_P_Davies’s research activities in Peru:
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Plate Lab retweeted
11 Sep 2023
We concluded translational dynamics modulate the co-translational folding of P67L sufficiently to sensitive it to VX-445. Personalized medicine will need to account for system level changes beyond single point mutations in targets.
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Plate Lab retweeted
11 Sep 2023
Attenuating global translation with low doses of cycloheximide (CHX) also reversed P67L VX-445 response.
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