Chemistry lab at the University of Oregon. Focused on molecular recognition, physical organic chemistry, and chemical biology of reactive S and Se species.

Joined November 2010
204 Photos and videos
New @ChemRxiv preprint: Closing the H2S/NO Signaling Loop: Nitric Oxide Regeneration by a Synthetic Zn2 Persulfide via Transnitrosation and Nitrite Reduction Great work @SayanAtta95, @keyanl10, & Alex! Computational work by @PAChampagne. chemrxiv.org/doi/full/10.264…
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Excited to share our Chem Rev on the bioinorganic chemistry of persulfides! Includes biological chemistry, bioinorganic models, inorganic systems, & isolable S/Se compounds. A huge congrats to Keyan (@keyanl10) for this heroic undertaking! pubs.acs.org/doi/10.1021/acs…
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Posters from 3 of our outstanding undergrads at the UO Undergraduate Research Symposium today! Great job Addison, Christopher, & Aleanna!
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🦆 🦆 The Duck approves! 🦆 🦆
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Pluth Group retweeted
(1/2) Our awesome Chemistry and Biochemistry graduate students represented us at the Chemical Biology and Physiology Conference 2025 in Portland, Oregon last week. Go Ducks!🦆 @v_derose @PluthGroup @uoCHandBIC @Gaby_Bailey_6 @Katelyn_alley14
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Do ‘gasotransmitters’ need to be gases? Andy makes the case in Redox Biology for Protic Small Molecule Bioregulators (PSMBs): a cross-cutting class of small molecules where protonation states impact biological speciation, permeability, & action. @agdavis98 doi.org/10.1016/j.redox.2025…
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Curious about the impacts of Lewis acids on persulfide & thioselenide chemistry? Check out Keyan & Addison’s paper using isolated ZnSSR & ZnSeSR complexes to directly study reactivity. Lots of insights from 77Se NMR & XRD! @keyanl10 @angew_chem onlinelibrary.wiley.com/doi/…
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Hydrogen cyanide (HCN) is the newest gasotransmitter & a key protic small molecule bioregulator. We developed a platform approach to develop & deploy biocompatible responsive chemical tools for HCN delivery. Check out Mike's paper in @angew_chem! onlinelibrary.wiley.com/doi/…
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🎃🎃Happy Halloween from the Pluth Lab! 🦇🦇
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New Chem Commun paper on Cys-activated H2Se delivery from isoselenocyanates. Includes mechanistic insights, solution characterization, and cell imaging. Great work Reis, Keyan, Christopher, Arman, Turner, & Kaylin! pubs.rsc.org/en/content/arti…
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New ACS Chem Biol paper out: No H2S needed - We show that an increasingly common approach for H2S detection actual reports on thiols and esterases. Nice work Haley (@hsmith922), Aleanna, Christopher, & Ally sorting out the chemistry of this system! pubs.acs.org/doi/10.1021/acs…
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Pluth Group retweeted
Congratulations to the 2025 recipients of the Chemistry and Biochemistry Graduate Student Teaching Awards: Sylvia Kennerly, Marie Kerns, Natalie Lakanen, Keyan Li, Rohan Myers, and Dario Nunez! tinyurl.com/yk8cydkp
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Check out our @InorgChem paper on Fe-NO formation from Fe(II) w/ SSNO(-) & SNO(-)! New insights into metal nitrosyl & reactive sulfur species formation from small S/N hybrid molecules. Great work Keyan (@Keyanl10), Juan, and George! pubs.acs.org/doi/10.1021/acs…
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New @InorgChem paper: Mo/W-CO complexes S₈ → COS! Highlights links between CO & reactive S species (Se behaves differently!) Initial 2023 @ChemRxiv preprint, now w COS quantification & new insights. Great work Toby, Haley & Keyan! @hsmith922 @keyanl10 pubs.acs.org/doi/10.1021/acs…
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Congrats to all the UO graduates today, including Andy & Haley! Dr. @agdavis98 & Dr. @hsmith922
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If you're at the UO Undergraduate Research Symposium, go check out the great work by Addison & Aleanna!
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Check out Shiva’s @ChemicalScience paper on using in situ ReactIR to measure host-guest binding affinities across hydrogen and halogen-bonding #supramolecular systems. Can be used w/ host or guest vibrations to measure Ka values. Great work @ShivaMoaven! pubs.rsc.org/en/content/arti…
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Congratulations Dr. Smith @hsmith922 on a great PhD defense! Thanks for all your work expanding our understanding of COS biological chemistry!
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Pluth Group retweeted
9 May 2025
Honored to receive the UO CAS Collegiate Faculty Award! Thanks @uocas for this recognition, and for recognizing the research contributions, creativity, and innovation from @PluthGroup members! cas.uoregon.edu/two-natural-…

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Congratulations Dr. Davis @agdavis98 on a great PhD defense! Lots of new insights into the reactivity and binding of reactive hybrid S & N anions!
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