Associate professor, virologist and mad scientist at Drexel University, Philly. Views are obviously my own.

Joined April 2016
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Some insight on Robert Malone, as I've done some work with him. I met Robert in 2016 when the company he was involved with was looking to repurpose existing drugs to combat Zika Virus. They needed help with background material and someone to bolster their science cred (1/13)
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Zachary A. Klase retweeted
Replying to @SecKennedy
Sec Kennedy: The editor-in-chief already clearly explained the reason for the removal in his notice (sciencedirect.com/science/ar…), which was that there were methodological flaws in the paper so serious that the conclusions were unsubstantiated. I mention the specific methodological flaw here, which involves inferring causality from the fact that VAERs reports clustered close in time to the day of the shot, an inherent characteristic of passive reporting systems and not even close to sufficient to conclude causality or even an association: x.com/jsm2334/status/2057919… Given this fatal flaw that was not detected by peer review, the entire argument in the paper falls apart, and the conclusion unsubstantiated. I explain why this statistical reasoning is invalid in my white paper on the USA vaccine safety monitoring system (see plot below) This white paper (annenbergpublicpolicycenter.…) summarizes the various US vaccine safety monitoring components, describing how they are supposed to work together, and providing specific suggestions on how it could be improved for more sensitive and specific detection of potential vaccine harms and more transparent communiation. It also highlights various valid and invalid analytical approaches that some use to analyze data from these systems -- and inferring causation from simple temporal reporting patterns in days since vaccine is one of them:
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I like that you clarified the first level... What do you think about @russvought 's attempts to make science completely political? Is that Gold Standard? statnews.com/2026/06/12/omb-…
Dr. Raymond Jacobson’s leadership will help ensure the first level of NIH review remains rigorous, fair, and transparent for all grant applications and contract proposals moving forward. These principles are paramount to implementing NIH’s Unified Funding Strategy, where impartial peer review with expert input remains a core tenant. Welcome, Dr. Jacobson!
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Zachary A. Klase retweeted
Attempting to force states like New Jersey to turn over sensitive, private voter data and threatening to withhold delivery of mail-in ballots is a blatant abuse of power. Trump knows his Administration is failing the American people, and if Republicans compete in a FREE and FAIR election they will lose. We won't be intimidated by these threats. We will continue to fight back. cnn.com/2026/06/10/politics/…
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It's not about health.
The Biden administration commissioned a federal study on alcohol consumption to shape the new dietary guidelines. The study found no net health benefit at any level of alcohol consumption, called for a ceiling of one drink per day, and tied alcohol to more than 200 ailments including various cancers and heart disease. One drink per day carries a 1-in-1,000 chance of an alcohol-linked death, the authors calculated. Two drinks daily bumps that to 1-in-25. That study was allegedly shelved before Kennedy's new dietary guidelines were released in January. The guidelines that did come out told Americans only to drink "less alcohol for better overall health" - no specific ceiling, no acknowledgment of the cancer and mortality data, "moderation" left undefined. The person who ran the project, Robert Vincent, lost his job in a federal staffing purge last spring. He published an editorial alongside the study Tuesday: "The evidence is really pretty straightforward. There is no safe level of alcohol." Vox reported last September that HHS declined to publish the study after the alcohol lobby petitioned to block its release. HHS says that characterization is inaccurate. The study is now published. The guidelines already went out without it. Kennedy spent months publicly crusading against food dyes, seed oils, and ultra-processed snacks. He said nothing about the federal study sitting in his department that found alcohol causes cancer at any consumption level. The science was straightforward. The lobby was louder.
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Zachary A. Klase retweeted
Let's walk through what actually happened here, in order. DOGE cut the USAID program specifically designed to prevent screwworm from crossing the U.S.-Mexico border. DOGE cut USDA's animal disease control and prevention funding. That funding had supported more than 180 outbreak investigations in 22 countries and capacity-building in more than 160 laboratories. The screwworm monitoring and response program that watched the border for exactly this parasite - cut. Then screwworm showed up in Texas cattle. Texas Governor Greg Abbott declared a disaster for Zavala and Uvalde counties this week. Agriculture Secretary Brooke Rollins went on CNBC this morning and blamed the Biden administration, 17 months out of office. Her specific words: "obviously not much had been done to push back." The program that was supposed to push back existed. DOGE eliminated it in March 2025. Rollins has been Agriculture Secretary since February 13, 2025. The cuts happened on her watch. Beef prices are already high. Ranchers in south Texas are now dealing with a flesh-eating parasite that was eradicated in this country in the 1960s - eradicated, specifically, using the sterile fly program her department defunded. The flies existed. The program existed. The budget existed. Until it didn't.
Trump's agriculture secretary laid the blame for the outbreak on the Biden administration, despite it being more than 17 months since Biden's term ended. thedailybeast.com/brooke-rol…
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Zachary A. Klase retweeted
As a reminder when Wakefield testified to Congress about his theory that MMR vax causes autism he failed to disclose he held a patent on a single antigen measles vaccine. He was looking to monetize his theory
The idea vaccines cause autism was invented by Andrew Wakefield in 1998 and was so thoroughly debunked he lost his license for gross malpractice And here we are 27 years later RFK Jr dredging up the same nonsense Such a tiresome waste of time
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Zachary A. Klase retweeted
If ICE or federal officers violate your right to record, there should be consequences. That's why I introduced the Right to Record Act to create a legal pathway to sue and hold them accountable — because no one is above the law.
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Zachary A. Klase retweeted
1/ Peter McCullough is a board-certified cardiologist with over 1,000 publications. He also sells you $66 capsules to “detox” a problem he invented, in a company he holds equity in. This isn’t bad science. It’s a business model.
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Zachary A. Klase retweeted
MedCram reviewed Ivermectin for Covid in April of 2020 showing that Ivermectin prevented replication of SARS-CoV2 in vitro. But made it clear that this was only in a test tube! youtube.com/watch?v=nHzBLfuN… We later reviewed (2 years later) data in humans showing it didn't work. youtube.com/watch?v=nHzBLfuN… Since then numerous trials have confirmed this with different doses: Key U.S. trials: 1) ACTIV-6, ivermectin 400 µg/kg daily x 3 days — JAMA 2022 U.S. decentralized, double-blind, randomized placebo-controlled trial at 93 U.S. sites. Ivermectin did not significantly improve time to recovery, and hospitalization/death was essentially identical: 1.2% vs 1.2%. 2) ACTIV-6, higher-dose ivermectin up to 600 µg/kg daily x 6 days — JAMA 2023 Also U.S., double-blind, randomized, placebo-controlled. Median recovery was 11 days with ivermectin vs 12 days with placebo, but the posterior probability of reducing symptoms by more than 1 day was <0.1%, and urgent care/ED/hospitalization/death was 5.5% vs 5.8%. Authors concluded it did not support ivermectin use. 3) COVID-OUT — NEJM 2022 U.S. phase 3 randomized, double-blind, placebo-controlled factorial trial of metformin, ivermectin, and fluvoxamine. For ivermectin, the adjusted odds ratio for the primary composite outcome was 1.05, and for hospitalization/death was 0.73 with a very wide CI crossing 1; the trial concluded none of the three drugs prevented hypoxemia, ED visit, hospitalization, or death. The closest “positive” ivermectin signal in a rigorous recent community trial is not U.S. and not placebo-controlled: the UK PRINCIPLE trial was open-label and found a small symptom-duration signal, but the authors still said the findings did not support ivermectin use for COVID-19.
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Good! @SecKennedy continued presence puts the health of our citizens and ou children at risk. He is an existential threat to the science, medicine and lives. No strategy that abides this is viable or ethical. politico.com/news/2026/06/10…
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Zachary A. Klase retweeted
The man running the agency responsible for 340 million Americans' health arrives at 10am, leaves by 4pm, skips his own division chief meetings, and when he does show up - scrolls his phone and gets described by colleagues as "checked out." Ebola is spreading. Six Americans already exposed. He has not briefed himself with CDC scientists. His response to a reporter asking if he was worried: "Yeah, we're working on it." The CDC is being run by a health economist with no public health experience who already has another full-time job running NIH. Half of the 27 NIH institutes have no permanent director. The top FDA drug regulator got fired in May - Kennedy found out after it happened. When measles killed two children in Texas, the CDC official leading the response asked repeatedly to brief Kennedy. He was rebuffed every time. The person actually running HHS operations is a longtime personal adviser whose policy spreadsheet - more than 50 items - is hidden from the department's own policy team. When Kennedy gets asked a question, his standing answer is "just run that by Stefanie." This is not a management philosophy. This is a vacancy wearing a title.
NEW: Major posts are vacant. Waves of scientists are gone. Ebola looms. How RFK Jr. manages HHS: “If the C.E.O. lacked deep expertise in the company’s business and the leaders of its most important divisions were missing, investors would revolt." nytimes.com/2026/06/07/us/po…
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Zachary A. Klase retweeted
I have never understood how this policy helps the mom whose daughter’s lifesaving cancer treatment is unaffordable.
For years, hospitals kept Americans in the dark about the true cost of care. Families made medical decisions without knowing the price—and too often got hit with bills that drained their savings. That ends now. Under President Trump’s leadership, HHS is enforcing hospital price transparency with real consequences. @DrOzCMS and I have a simple message for hospitals: Post your actual prices. Come into compliance immediately—or face serious consequences.
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Zachary A. Klase retweeted
Replying to @ProfKlase
I went to med school decades ago and we had TONS of nutrition education at @KeckMedicineUSC and so did other schools- no one needed RFK to weigh in). 🪱🧠
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Zachary A. Klase retweeted
Biochemistry and nutrition is ~20% of step 1. Not to mention that it’s also in covered in anatomy, physiology, endocrinology, and GI. But sure take credit for “adding nutrition” you jokers.
Nutrition to be added to doctors’ licensing exams thanks to RFK Jr. push trib.al/c641P2k
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Zachary A. Klase retweeted
Leaving this here, in case anyone is wondering why we have screwworm in the US for the first time since the 1960s. The DOGE stupidity from Trump and Rollins will end up COSTING taxpayers money.
Bird flu, screwworm monitoring among foreign aid programs killed by Trump agri-pulse.com/articles/2263…
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Zachary A. Klase retweeted
Researchers at Stanford University modeled how many people could die or be disabled in 25 years if vaccines for polio, measles, rubella or diphtheria were no longer available. We illustrated their findings. projects.propublica.org/chil…
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This, of course, was already there and had already been something that people thought was important. Any change we see will be someone else's work. MAHA is a grift. jamanetwork.com/journals/jam…
JUST NOW: @SecKennedy announces major nutrition science reforms: “Today represents one of the most important course-corrections in modern American medicine.” “For the first time, nutrition science will have a meaningful presence across all three steps of the United States Medical Licensing Examination.” “Approximately 15% of content across the examination sequence will assess nutrition science and its clinical application using evidence-based standards.”
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Can we cut this guy loose now? Because he's going to kill lots of Americans with his anti-science and anti-medicine. The only reason he got the job was to buy votes... Please, cut him loose? Our kids will thank you. politico.com/news/2026/06/06…
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Zachary A. Klase retweeted
Subaru Park turned orange for National Gun Violence Awareness Day to call attention to our nation’s preventable gun violence crisis.
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40 years ago deaths from CVD were a lot higher....
🚨 BIG PHARMA’S CHOLESTEROL LIE IS KILLING YOUR BRAIN 40 years ago a cholesterol level of 300 was perfectly fine. Today they scream if you go over 190… and shove you on meds immediately. They have done this to me. The side effects? Alzheimer’s. Dementia. Muscle wasting. Memory loss. And now they’ve added breast cancer — because your sex hormones are made from cholesterol. The Framingham Heart Study spent 40 years trying to prove cholesterol causes heart disease… and still hasn’t. Here’s why: Your brain is the fattiest organ in your body and it loves cholesterol as fuel. Starve it and you’re begging for disaster. Barbara O’Neill drops the bomb: If you’re on cholesterol-lowering drugs, you can stop immediately. One side effect? Your memory may actually return. This isn’t advice — it’s what they don’t want you to know. Watch the full clip👇
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