Wow! I remember when this was your dream Rob People don’t have a clue about how hard it is to get our great science from bench to bedside Congratulations!🙌
Grateful for this lovely writeup of our work on chemo induced infertility in @EmboMolMed! Many thanks to @norahspears@AgnesStefansd and Adomas Liugaila
Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage? embopress.org/doi/full/10.10…
Hormone-free infertility treatment....well, here we are finally...it's a clinical reality!! 20 years ago, our old IVM alliance: myself, @jeremygthompso2, Johan Smitz and @MdevosMD made this our aspirational goal. Now Dr Lan Vuong and @TuongMHo got there!!
New #openaccess review published as part of the Reproductive Ageing collection:
'Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes' by Bettina P Mihalas et al.
Read it here: doi.org/10.1530/REP-23-0510
What an achievement from @TuongMHo and the @research_hope , completely hormone-free ART with good pregnancy outcomes. Only possible with an advanced IVM system. Awesome - we have been waiting a long time to get to this point. Congrats!!
Hormone-free ART for PCOS women | Presented at ESHRE 2024 to a large audience.
It is feasible and efficient. Single blastocyst transfer with good pregnancy outcome.
Interested in IVM in hyperresponders? 👉 Check our poster on (cori)follitropin priming of antral follicles and the impact on oocyte yield and pregnancy rates #ESHRE2024 @BrusselsIVF @UZBrussel@ESHRE
fantastic work @TuongMHo@research_hope . OTO-IVM (ex vivo IVM; immature oocytes from ovarian tissue) is a no-brainer for fertility preservation for a lab routinely running IVM for infertility treatment. Easy peasy !!
OTO & CAPA IVM | We retrieved immature oocytes from ovarian tissue, applied biphasic IVM. We got 22 MII oocytes for vitrification in this case. Really potential !
Wow..!! Zero stimulation ART is a thing! This is what can be achieved when you have an excellent quality and very experienced IVM clinic. Congrats @TuongMHo and @research_hope
Why stimulation for PCO women?
Today we have 4 cases of IVM for PCO. We collected at least 20 oocytes each, without any gonadotropin priming. Our maturation rate is > 60%. > 90% of our IVM cases have blastocysts for transfers.
Good question … An inverse relationship between the oocyte developmental status at collection and the length of pre-IVM culture has been hypothesized (Gilchrist et al. 2024) @RG_EggLab. Oocyte developmental status depends on gonadotropin (dose) priming, follicle size. #ESHREjc
I do not believe we should see IVM as replacing IVF. However IVM should be acknowledge for their advantages and should be considered as a complementary tool available for the treatment of a selected groups of patients (hyperresponders) within a conventional IVF program. #ESHREjc
academic.oup.com/humupd/arti… Good to read about the new IVM system. We have good results with this. More than 800 babies have been born. Three-year follow up of children has been assuring. #ESHREjc
🪩 IVM in all its glory 🪩
The study of Mostinckx et al (doi.org/10.1093/humrep/dead2…) addressed
🧫 In Vitro Maturation (IVM)
vs
💉Ovarian Stimulation (OS)
for women with high AMH👸🏻
(aka ~PCO aka hyper-responders)
Here a 🧵 summary in preparation for #ESHREjc this Friday👇🏻
🪩 IVM in all its glory 🪩
The study of Mostinckx et al (doi.org/10.1093/humrep/dead2…) addressed
🧫 In Vitro Maturation (IVM)
vs
💉Ovarian Stimulation (OS)
for women with high AMH👸🏻
(aka ~PCO aka hyper-responders)
Here a 🧵 summary in preparation for #ESHREjc this Friday👇🏻