Congrats to the authors @Yale on this exciting and important work! #BrainTCellsRule || The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour | Nature nature.com/articles/s41586-0…
Very happy to share our new recently published work!
🧬 lrrtm4l1 knockout in #zebrafish leads to:
⚠️ Increased anxiety
❌ Reduced aggression
...without changes in locomotion or social interaction.
A fresh angle on #LRRTM4 and neuropsychiatric disease.
🔗 doi.org/10.1111/apha.70042
Our results highlight LRRTM4L1 as a potential modulator of dopaminergic & adenosinergic signaling—linking synaptic structure to emotional behavior.
This may offer new insight into aggression/anxiety in neuropsychiatric conditions like ASD & Tourette's.
Key findings:
High lrrtm4l1 expression in brain regions homologoud to amygdala & hippocampus
KO zebrafish anxious in 3 assays (OFT, novel tank, light/dark)
Less aggression in mirror-induced tests
Why does this matter?
LRRTM4 is a synaptic adhesion protein linked to aggression & autism in humans, but its functional role in behavior has remained unclear.
We used zebrafish to dissect behavior, transcriptomics & the metabolome.
Antipsychotics are often prescribed to suppress hyperaggression. Do they really suppress aggression or just cause sedation? Antipsychotics target dopamine receptors. Our new study, published today @Nature, uncovered the role of dopamine in aggression.
nature.com/articles/s41586-0…
Only two weeks left to apply!!!
The Young Researcher Committee (#YoRC) of @eu_fish is looking for TWO new members! 🎉
Do you want to contribute to empowering early-career researchers in the #zebrafish community, apply by January 31st!
forms.gle/t1ydTPKU4KsEmsLH9
📣 Time to register : 7th European Zebrafish Principle Investigators Meeting will be held in Paris, April 2- 5, 2025
Early bird until December 15th, 2024
Abstract submission open. Deadline December 15th 2024. 👉 lnkd.in/e4pDe7uh#zebrafish@eu_fish
What your brain's microbiome means for your health? The answer is: Absolutely nothing, as there is none. And no, brain microbiomes play also no role in neurodegenerative disorders like Alzheimer's. This article is not based on scientific information that is credible.
In this week's new issue: What your brain's microbiome means for your health.
Grab a copy in shops now or download our digital editions. newscientist.com/issue/3510/
Zebrafish peeps: I understand after many conversations at the Kyoto meeting that not everyone is aware of the Room Temperature zebrafish sperm paper. In Vitro Storage of Functional Sperm at Room Temperature in Zebrafish and Medaka | Zebrafish (liebertpub.com)