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Francesco Ricci Lab @RicciLab

Professor @ Univ. of Rome Tor Vergata. #Nanotechnology, #SyntheticBiology, #Nanomachines and #Nanodevices.

Joined May 2017
  • Tweets 621
  • Following 474
  • Followers 2,282
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Francesco Ricci Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
26 Oct 2025
Immune-Induced Antibody–DNA Hybrid Condensates | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Immune-Induced Antibody–DNA Hybrid Condensates

We report here the combined use of Watson–Crick and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. To achieve this, we have used an antigen-conjugated...

pubs.acs.org
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New paper from our group just out in @J_A_C_S! We show the combined use of DNA-DNA and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. pubs.acs.org/doi/10.1021/jac… Congrats to Sara (@sara29_ss) for her first first-author paper!👇🧵 1/n

Immune-Induced Antibody–DNA Hybrid Condensates

We report here the combined use of Watson–Crick and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. To achieve this, we have used an antigen-conjugated...

pubs.acs.org
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We also show that by simply replacing the antigen on the DNA nanostar we can induce the phase separation of different condensates in a orthogonal way without any crosstalk...here is the microscopy image of three condensates formed upon addition of three different antibodies! 5/n
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All results were nicely described by theory and simulations of a phase-field model by our collaborators Lorenzo Rovigatti and Marco Cappa @SapienzaRoma. Finally thanks to co-corresp author @erica_delgrosso for her invaluable support and @AIRC_it and @ERC_Research for funding. 6/n
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The next Functional DNA Nanotechnology workshop #FDN2025 (Rome 15-17 October) is just around the corner! Due to last minute cancellations, we still have a couple of places available if anyone is interested... fdn2025.com/
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All places have been filled!
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Nice to see this collaborative work out in @angew_chem. We joined forces with @Ale_Sorrenti1 and @PuigmartiLuis to achieve non-equilibrium steady states using DNA-based systems and controlled RNA fuel supply. Congrats to @erica_delgrosso and @JamesDNicholas🥳
Alessandro Sorrenti@Ale_Sorrenti1
1 Sep 2025
📢Check out our new paper! ✨ We demonstrate non-equilibrium steady states of a DNA-based system that dynamically adapt in real-time to subtle on-the-fly variations of a RNA fuel supply, and correspond to a true non-equilibrium composition of the system. doi.org/10.1002/anie.2025129…
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Francesco Ricci Lab retweeted
Erica Del Grosso@erica_delgrosso
4 Aug 2025
Excited to see our latest work finally out in @NatureNano 😍😍. Great collaboration and many thanks to all the authors @leonard_prins @RicciLab @benjamino_acid and @Epenocchio 🥳🥳
Nature Nanotechnology@NatureNano
1 Aug 2025
New paper online: An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions. "...mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions." nature.com/articles/s41565-0…
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Great to see this is now out in @NatureNano! Thanks to @leonard_prins for this (yet another) collaborative project...kudos to @erica_delgrosso and Ben Roberts for combining experiment and theory in such a nice way. Thanks also to @EPenocchio for help with the theoretical part!
Nature Nanotechnology@NatureNano
1 Aug 2025
New paper online: An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions. "...mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions." nature.com/articles/s41565-0…
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Hurry up! Today is the deadline to submit an abstract for the next Functional DNA Nanotechnology workshop #FDN2025, Rome 15-17 October 2025! Co-organized with Tim Liedl (@CeNS_LMU) and Fritz Simmel. fdn2025.com
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The paper describing our MAIGRET (Molecular Assay based on antibody-Induced Guide-RNA Enzymatic Transcription) system is finally out in @NAR_Open! academic.oup.com/nar/article…. @ERC_Research, @AIRC_it 1/n

MAIGRET: a CRISPR-based immunoassay that employs antibody-induced cell-free transcription of CRISPR...

Abstract. Here we report on the development of a CRISPR-based assay for the sensitive and specific detection of antibodies and antigens directly in complex

academic.oup.com
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The name of the assay is an homage to one of the best examples of CRISPR-based sensors (SHERLOCK, @Sherlock_Bio) developed by @zhangf, Collins colleagues. While SHERLOCK detects DNA/RNA strands, MAIGRET enables the detection of proteins, antibodies and other molecules. 5/n
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Finally, big congrats to our PhD student Francesca Miceli for her first first-author paper and to all the coauthors (@Simona_Ranallo, @BracagliaSara, @SorrentinoDa, @alessan_porch).
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Francesco Ricci Lab retweeted
Velia Siciliano@VeliaSiciliano
18 Feb 2025
*ALERT* If you are a bioengineer (or related), if you use synthetic biology for health-related applications, and you wish to start your own lab in a neat place (Naples), in a fantastic research institute, stay tuned, a call will be coming out! DM me if you want to have more info!
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