Joined November 2011
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I'm excited to share that I will be starting my lab at NTU Singapore. It is bittersweet to be moving halfway around the world. On one hand, I'm excited for a new adventure. I have spent my entire adult life chasing this dream, and it's finally happening. On the other hand, I still love America and believe in all of the good that it stands for. My parents moved here to give me the gift of the American Dream and I never thought I would experience what it's like to be an immigrant to a new country myself. I can only say that life has a way of offering blessings in disguise, and I’m grateful for this opportunity in every way.
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Richard She retweeted
Excited to announce a powerful new one-two punch for voltage imaging from our lab and collaborators! In two new preprints, we introduce ASAP6c for high-throughput population spike-recording, and ASAP7yfor deep, subthreshold 2P imaging. 🧵 1/14
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Funny American living abroad situation: I have a new HSBC credit card, but my checking account is with another bank (DBS). Credit card bill is due. Log in to app: "no eligible accounts to transfer money from." Stuck. Chat with customer support. Apparently everyone in Singapore "knows" that payments here work on a "Push" vs. a "Pull" system. In the US, you just setup Autopay and the credit card pulls your money from wherever you bank. In Singapore, you go to where your money lives and push it onto your credit card to settle the bill. 2-3 business days, don't forget to do it on time 🤣 @patio11
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Everyone's been dunking on this video of a travel influencer couple showing off their photo book collection. But none of you realize that you've been suckered. This isn't a real couple -- it’s a mega-viral AI marketing campaign by the photo book company Pixory. They’re stealing a real Instagram influencer’s likeness to run a network of fake TikTok accounts, pumping out daily fully AI-generated videos just to push a discount code. See for yourself (tiktok.com/@tatianasphotoarc…) This is the state of our internet commons now. A reminder for us olds: everything you see on the internet is fake. Your feed is a stealth marketing campaign. vulture.com/article/social-m… @max_spero_ we need Pangram on the case ASAP
Embarrassing levels of consumption.
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Richard She retweeted
I ran comms for Google during Oracle v. Google in 2012, tech's last big trial of the century. Watching Musk v. Altman has me flashing back hard. Fifteen observations on the trial comms war so far, in no particular order:
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5.8k twitter bots have retweeted this post within the first two hours. Great story: AI cures dog cancer. Perfectly engineered in a lab for virality. Except it's a load of crap. Meanwhile, all the real biologists left this platform long ago and so all we're left with is this AI slop
this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get
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Richard She retweeted
1/ The technology behind @Tahoe_ai is now published in Nature Cancer. GENEVA: pool diverse disease models into one mosaic tumor → treat → deconvolve response at single-cell resolution. The architecture that had to exist before datasets like Tahoe-100M were possible.
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Richard She retweeted
This one surprised us : deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author Joe McKellar and all co-authors ! published in Cell sciencedirect.com/science/ar…
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Some of you are Monitoring The Situation just for the sake of a few Twitter likes. Me, I told my mom a week ago that she should rebook her flight through Dubai, which was scheduled for today (she did not listen to me)
IM NOT HAVING A MANIC EPISODE MOM THERES A WAR GOING ON AND TWITTER NEEDS ME
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In retrospect, the Polymarket Odds for the Iran Strike today were really mispriced
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I just got married into this culture. My wife grew up in KL and I grew up in Seattle. Even my Chinese parents have never been exposed to this level of tradition; our tea ceremony had a gate crashing, a Dai Kum Mun Jie, a wedding car, and a million ritualistic details that don't exist anymore in mainland China. It's a really striking contrast to the Chinese diaspora elsewhere
Quick Kuala Lumpur review 🧵 * Horrible weather. Muggy, hot. Might be worse than Bangkok. * Questionable city planning. One of the few big Asian big cities where I wish I had a car. Some streets are difficult and dangerous to walk through. * Grab (Southeast Asia's Uber) usually takes a long time to come. Probably not enough drivers bad traffic. * Heavy-flavor and calorie-dense foods abound. I am a fan but know I'll gain hella weight if I were to live there (love bak kut teh, durian, and satay especially). Not surprised that the average Malaysian seems a bit on the pudgier side. * The Malaysian Chinese are secure in their identity, as I discussed in the quoted post, and I really respect that and think every Chinese can learn from them. * I know racial tensions and conflicts have been big in Malaysia for a long time (which probably is the main reason why the Chinese are extra cooperative and proud there), but people seem to coexist fairly well in KL in 2026. Felt the same about Penang when I was there last May. Hell, Malaysians even invented a term, "Kongsi Raya", which denotes Chinese New Year and Eid ul-Fitr (end of Ramadan) coinciding, leading to big simultaneous multicultural celebrations.
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Just checked my upcoming wedding vows with @Havelock_AI. Orarilty score 82% has the Fed Governors beat, but that's a low bar. Do I need to shoot for 100%?
In the process of scoring every Fed speech over the last 20 years on @Havelock_AI. Still not done yet. But no surprise that district Presidents, who tend to do more community outreach talks, tend to score higher
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I'm using ChatGPT 5.3 to help polish my wedding vows and it just dropped in a fake C.S. Lewis quote that made my jaw drop. It was so good, I couldn't believe it wasn't real.
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Getting DoorDash in Asia is ridiculously affordable. And yet there's still a generational divide. Old people simply like spending the whole morning going to the store. It gives me a new hypothesis: with our new endless content dopamine drips, the monetary value of leisure time has gone up. Young people just aren't willing to sacrifice a bit of extra time to save a few bucks. What does this mean for the economy when we all live like landed gentry?
I feel insanely guilty when I order DoorDash once every 6 months and yet there are people spending a solid 1/3 of their income on it 🤯
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I just want to say that Amodei's fear of left-handed handed bacteria taking over the world is totally unfounded. The human brain already uses D-serine, the mirror image of the normal amino acid. It's a key neuromodulator. Bacterial cell walls already incorporate D- amino acids to resist proteases. Peptide drugs already contain D-leucine for improved stability. It's a clever trick that's useful sometimes. But all you need is an enzyme called racemase to flip everything back to it's normal mirror image. In the metabolic desert of the deep ocean, microbes absolutely do eat both forms of the amino acids. There is NO unexploited metabolic niche for mirror life to colonize. Now nothing alive today uses mirror image nucleic acids. But if Claude ever did make such a bacterium, it would be the easiest target ever to drug. Just about every one of its essential proteins could be drugged with much less risk of off-target effects on regular life. We have loads of very good antibiotics because it's easy to find drugs that specifically kill bacteria without killing human cells. We have very few chemotherapies that aren't highly toxic because it's very hard to find drugs that kill tumors without also killing healthy cells. Mirror bacteria are dead on arrival, a lab curiosity at best. They've got a built in kill switch, all alien life is just chemistry at the end of the day, nothing to fear hombres
Thanks for the thought-provoking piece. My main critique is that you are overemphasizing flashy but low probability events like “left-handed bacteria,” while merely giving lip service to the risk of extreme economic concentration of power, which is very real and materializing as we speak. Anthropic is reportedly raising funds at a $350B valuation, and the wealth created thus far has been concentrated into a few hundred (perhaps more like dozens) high net worth individuals / institutions. It’s looking increasingly likely to me that none of the leading AI labs will IPO until they reach valuations in the trillions, at which point retail investors will finally be able to get shares. In order for retail to get a 100x return on these investments, which was achievable for Apple, Microsoft, Amazon, and Google, the valuations of the AI labs will need to reach hundreds of trillions of dollars, meaning it’s likely too late for a more equitable redistribution of wealth. Simply put, you are currently exacerbating the problem. The consequences of this are that voters may take matters into their own hands and push for either or both 1) more aggressive / nonsensical forms of redistribution — the CA Founders’ Tax is just the beginning or 2) a drastic knee-capping of the AI industry in America, which make the CCP dominance scenario more likely. The solution is to enable retail ownership now, increasing the number of Americans with economic exposure to Anthropic and other AI labs from hundreds of people to millions.
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How starved we are for demonstrations of courage and conviction in this modern age of narcissism. He sure didn't do it for the money, the fame, or the Instagram likes.
my late grandfather loved Alex Honnold-level danger (parachuting into wildfires) with 5 kids at home ppl always ask “how could someone do that to his family?” but knowing someone who lived so fully & answered a calling that big made us all better. drives like that are gifts
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Richard She retweeted
Our CytoTape work is published today in @Nature! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. nature.com/articles/s41586-0…
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When you buy furniture online from China, they sometimes don't bother even sending instructions. It's just a passive aggressive **don't be a r*tard, figure it out yourself** And they don't even play with Legos as kids
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One of the small joys in life is winning a game of blitz on chess.com with a nice tactic, having enough time to type "it's joever" in chat, and your opponent has no idea what you're talking about because they're from Puerto Rico and then they resign
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Richard She retweeted
Excited for the publication of our recent work on how pyramidal cells shape the identity of interneurons in the Cortex! Big shout out to @artofbiology and Sherry Jingjing wu! nature.com/articles/s41586-0…

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Do Uber drivers use FSD these days? If I were a math PhD I would totally do this. Heck I could Claude Code and deliver UberEats
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