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The Rotello Group @RotelloGroup

It is all about particles...

Joined June 2011
  • Tweets 722
  • Following 162
  • Followers 1,367
294 Photos and videos
Hurray!! Congratulations to Prof. Vincent Rotello for being recognized in Research.com's 2024 list of top scientists as 99th in the U.S and 223rd in the world among the Best Materials Science Scientists. umass.edu/news/article/umass… research.com/scientists-rank…
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Congratulations to Prof. Vincent Rotello for being ranked 220 in the world and 115 in United States by Research.com research.com/scientists-rank…
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Congratulatons to Prof. Vince Rotello for being placed as the top 0.05% of all scholars worldwide by ScholarGPS. scholargps.com/scholars/1940…
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Liang Liu and colleagues developed a responsive bio-orthogonal catalysis system utilizing an enhanced green fluorescent protein (EGFP)–nanozyme (NZ) composite (EGFP-NZ) mdpi.com/1996-1944/17/7/1507

Controlled Bio-Orthogonal Catalysis Using Nanozyme–Protein Complexes via Modulation of Electrosta...

Bio-orthogonal chemistry provides a powerful tool for drug delivery systems due to its ability to generate therapeutic agents in situ, minimizing off-target effects. Bio-orthogonal transition metal...

mdpi.com
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In this research, Zhai et al. uncovers a new molecular process that may utilize ROS-Nrf2-p62 signaling to regulate macrophage Mox polarization. This discovery offers potential for enhancing the safety and effectiveness of nanomaterial usage. sciencedirect.com/science/ar…
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In this article, Zhang et al. reports gold nanoparticle based bioorthogonal nanozyme for repolarizing macrophages from M2-like to M1-like phenotype providing a potential strategy for anticancer immunotherapy. pubs.rsc.org/en/content/arti…

Polarization of macrophages to an anti-cancer phenotype through in situ uncaging of a TLR 7/8...

Macrophages are plastic cells of the immune system that can be broadly classified as having pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. M2-like macrophages are often...

pubs.rsc.org
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Congratulations William the 2024 RCSA fellowship x.com/RCSA1/status/177265505…

Research Corporation for Science Advancement@RCSA1
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Eight postdoctoral scholars have been selected to participate in the first year of the #RCSAFellows initiative, which aims to help increase faculty diversity in the physical sciences through job search preparation and community building. bit.ly/3TQ6Vy2
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Nabawy and colleagues describe the creation all-natural antifungal treatment by gelatin-based nanoemulsion platform integrated with a natural essential oil with antimicrobial properties, aimed at treating biofilm associated fungal infections. pubs.rsc.org/en/content/arti…

Nature-derived gelatin-based antifungal nanotherapeutics for combatting Candida albicans biofilms

Infections caused by fungi are emerging global health challenges that are exacerbated by the formation of fungal biofilms. Further challenges arise from environmental contamination with antifungal...

pubs.rsc.org
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Hirschbiegel et al. reflect upon the impact of our inaugural work on nanoparticle hydrophobicity and protein corona formation on the scientific community in this Materials Horizons 10th anniversary special. Check it out! pubs.rsc.org/en/content/arti…

A reflection on ‘Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic...

Nanomaterials are at the forefront of modern therapeutics. The systemic administration of nanomaterials, however, can disrupt red blood cells. This hemolysis impacts the applicability of nanomateri...

pubs.rsc.org
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In this article, Hirschbiegel (@cm_hirschbiegel) & Goswami et al. showed how modulating the hydrophobicity of the polymer scaffold can enhance catalyst loading efficacy, catalytic activity, and serum stability of bioorthogonal polyzymes. Read more: onlinelibrary.wiley.com/doi/…

Engineering of bioorthogonal polyzymes through polymer sidechain design

Synthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide bioorthogonal nanocatalysts. These “polyzymes” catalyze the in situ generation of therapeutic agents without...

onlinelibrary.wiley.com
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Check out RSC Materials Horizons' (@MaterHoriz) Community Spotlight at blogs.rsc.org/mh/2023/12/11/…
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In this review, Goswami and Gupta et al. discuss the importance of nuclear targeting and how the interplay between nuclear import pathways and nuclear localization signal (NLS) motifs can help pave the way for better therapeutic design and delivery. pubs.rsc.org/en/content/arti…

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In this article, Profs. Epple, Rotello and Dawson discuss the opportunities and challenges of ultrasmall nanoparticles. Read more: pubs.acs.org/doi/full/10.102…

The Why and How of Ultrasmall Nanoparticles

ConspectusIn this Account, we describe our research into ultrasmall nanoparticles, including their unique properties, and outline some of the new opportunities they offer. We will summarize our...

pubs.acs.org
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Thrilled to see this work highlighted in Materials Horizons 10th anniversary regional spotlight collection: The Americas ! @MaterHoriz
The Rotello Group@RotelloGroup
18 Mar 2022
Intracellular bacterial infections are difficult to treat. In this study, Hardie, Makabenta et al. leveraged bioorthogonal catalysis to generate antibiotics within host macrophages (in situ) to fight intracellular infections. Read more here: doi.org/10.1039/D1MH02042K
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In this study, Huang & Fedeli et al. examine the effects of ligand headgroups on the dynamics of organic ligands attached to gold nanoparticles. Read more: pubs.acs.org/doi/full/10.102…

Modulation of Gold Nanoparticle Ligand Structure–Dynamic Relationships Probed Using Solution NMR

Ligand dynamics plays a critical role in the chemical and biological properties of gold nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and hydrophilic...

pubs.acs.org
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In this work, Makabenta et al. stabilize and deliver non-antibiotic antimicrobial phytochemicals using polymer-stabilized biodegradable nanoemulsions, achieving high bacterial clearance (99% bacteria reduction) in a MRSA-induced murine model of peritonitis sciencedirect.com/science/ar…
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In this review, Keum & Hirschbiegel et al. discuss current strategies for intracellular catalysis and applications of biomimetic and bioorthogonal nanozymes. Check it out! nanoconvergencejournal.sprin…

Biomimetic and bioorthogonal nanozymes for biomedical applications

Nano Convergence - Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific...

link.springer.com
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In this work, Makabenta & Nabawy et al. tackled difficult-to-treat wound biofilm infections by integrating antimicrobial polymeric nanoparticles into hydrogels, clearing 99% of bacterial infection and significantly enhancing wound healing in vivo. doi.org/10.1016/j.jconrel.20…
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In this work, Nabawy & Gupta et al. demonstrate the design and application of a biodegradable nanoemulsion that encapsulates a palladium-based TMC, generating bioorthogonal nanocatalysts for anti-cancer applications. pubs.rsc.org/en/content/arti…

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In this article, Park et al. in collaboration with the @VachetLab, report a combination therapy for biofilm infections. Silver nanoclusters and eugenol integrated into polymeric biodegradable nanoemulsions demonstrated synergistic antimicrobial activity. pubs.acs.org/doi/10.1021/acs…

Synergistic Treatment of Multidrug-Resistant Bacterial Biofilms Using Silver Nanoclusters Incorpo...

Multidrug resistance (MDR) in bacteria is a critical global health challenge that is exacerbated by the ability of bacteria to form biofilms. We report a combination therapy for biofilm infections...

pubs.acs.org
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