Understanding the molecular and genetic mechanisms of a variety of developmental disorders and paediatric diseases to improve global child health outcomes.
Joined February 2021
- Tweets 95
- Following 122
- Followers 286
- Likes 199
24 Photos and videos
Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models. @cirunalab @SickKidsNews
rdcu.be/eIT2f
scienmag.com/oxidative-stres…
@SickKidsNews @CIHR_IRSC @NatureComms @sickkids @UofT @mogen
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Great work being done by postdocs in @yunli lab in the @SKDevStemCell program at SickKids.
youtube.com/watch?v=fODijlKw…
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Developmental, Stem Cell & Cancer Biology retweeted
4 Feb 2025
Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm
can01.safelinks.protection.o…
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Developmental, Stem Cell & Cancer Biology retweeted
29 Nov 2024
Great job @FabianDoktor and the @Zani_Lab! Another important paper highlighting the effects of #EVs on fetal hypoplastic lungs 🫁! @SKDevStemCell @Me4Ped @cdhintl @CDHUK_CHARITY
29 Nov 2024
Delighted to share our latest research on #EV based therapies for fetal pulmonary hypoplasia secondary to oligohydramnios published now at the Journal of Controlled Release! kwnsfk27.r.eu-west-1.awstrac…
@sickkids @CIHR_IRSC @dfg_public @EupsaSurgeons @APSASurgeons @JCRnEDITORS
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Developmental, Stem Cell & Cancer Biology retweeted
2 Sep 2024
Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s41556-0…
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Ulcers increase the risk of gastric cancer, but the mechanisms underlying this association remain unclear. The Kim and Guo labs demonstrate that YAP signaling promotes both gastric regeneration and metaplasia, a precancerous lesion. cell.com/cell-reports/fullte…
lab.research.sickkids.ca/kim…
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Developmental, Stem Cell & Cancer Biology retweeted
28 Oct 2023
Weifan's paper has been featured on the cover of Nature Cancer @NatureCancer
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Developmental, Stem Cell & Cancer Biology retweeted
A newly discovered protein-protein interaction has sparked the development of a novel treatment for #glioblastoma 🧠
Published in @NatureCancer, the #SKResearch team is now working to advance this therapy into clinical trials as soon as possible.
Read ➡️ bit.ly/469uANh
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Developmental, Stem Cell & Cancer Biology retweeted
12 Sep 2023
Today, we report in @NatureCancer a new approach to treat glioblastoma (GBM). First and foremost, this is the work of recently graduated Dr. Weifan Dong, who has championed this study for the past 7 years with ingenuity and perseverance. @SickKidsNews @SKDevStemCell @MoGen_Grad
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Great work!! Congratulations!
3 Apr 2023
Excited to share our paper "Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes" science.org/doi/10.1126/scia…, led by our extremely talented postdoctoral fellow Xian Wang.
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Kim lab.research.sickkids.ca/kim… and Wilson wilsonlab.org labs at SickKids have defined the epigenetic regulation of mesenchymal niche signals in stomach and intestinal development.
nature.com/articles/s41467-0…
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Developmental, Stem Cell & Cancer Biology retweeted
4 Jan 2023
First 2023 issue is out! cell.com/neuron/current
Cover art by Siqi Ou illustrates Chen & coll. findings on mechanosensitive brain tumor cells that form the blood-tumor barrier to mask chemosensitivity
Paper: cell.com/neuron/fulltext/S08…
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Dr. Tae-Hee Kim's lab lab.research.sickkids.ca/kim… identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis.
sickkids.ca/en/news/archive/…
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Congratulations Dr. Vijay Ramaswamy @vijayvijay1979 for Canada Research Chair award (Tier II) to identify weaknesses in medulloblastoma and ependymoma, the first and third most common paediatric brain cancers.
lab.research.sickkids.ca/ram…
@SKDevStemCell @SickKidsCancer @sickkids
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Great work from @XiHuang18 lab.
lab.research.sickkids.ca/hua…
@SRC_CRS @CIHR_IRSC @SickKidsCancer @braincancercan @NoBrainCancer
A SickKids team led by Dr. Xi Huang has uncovered the mechanics of the blood-tumour barrier, laying the foundation for more effectively treating medulloblastoma, the most common malignant paediatric brain tumour.
Read more ➡️ bit.ly/3fwHHmK #SKResearch
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Congratulations Maria!
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Congratulations!!
21 Sep 2022
🥳YAYY!!🥳Incredibly happy to share our work on the Human origins of Group 4 Medulloblastoma published today in @Nature. Massive collaborative effort to nail down a cell type found only in developing human brains as the cell of origin of these tumors
nature.com/articles/s41586-0…
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Congratulations to Dr. Tae-Hee Kim @SKDevStemCell lab.research.sickkids.ca/kim… for securing the @CIHR_IRSC operating grant titled: Mechanisms of intercellular communications in gut homeostasis and disease.
@SickKidsNews @sickkids @CIHR_ICR
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Developmental, Stem Cell & Cancer Biology retweeted
22 Jul 2022
Dr. Xian Wang is one of our Brain Tumour Research Fellowship recipient. We are so grateful for is amazing work and how he is helping advance brain tumour research. Learn more about his research project: bit.ly/3RXf94f
@XiHuang18 @SKDevStemCell @uoftmie
Microrobotic Swarms for Intracellular
Measurement with Enhanced Signal-to-Noise
Ratio - recent work of Dr. Xian Wang published in ACSNano from
@XiHuang18 lab @SKDevStemCell lab.research.sickkids.ca/hua… and Dr. Yu Sun's lab mie.utoronto.ca/faculty_staf……
@uoftmie
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Microrobotic Swarms for Intracellular
Measurement with Enhanced Signal-to-Noise
Ratio - recent work of Dr. Xian Wang published in ACSNano from
@XiHuang18 lab @SKDevStemCell lab.research.sickkids.ca/hua… and Dr. Yu Sun's lab mie.utoronto.ca/faculty_staf……
@uoftmie
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They have developed a magnetic robotic system to control fluorescent dye-coated nanoparticles to form a swarm for intracellular ionic measurement. Their system displays a signal-to-noise ratio ten times higher than traditional ionic dyes.
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Using this approach, they have discovered mechanical force-activated calcium dynamics at nanoscale resolution within single brain tumour cells.
pubs.acs.org/action/showCitF…
@SKDevStemCell @SickKidsNews @CIHR_ICR @BrainTumourFdn @acsnano @SRC_CRS @theABTA @sickkids @SickKidsCancer
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