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Sébastien Rigali @SebaRigali
Joined March 2012
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From spelunking to new #antibiotic discovery! Fantastic work in collaboration with HEDERA-22. Lunaemycins, first new bioactive molecules found from cave moonmilk-dwelling #Streptomyces. See our work at lnkd.in/egHScnTx. @Strep_papers @saveantibiotics
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Very excited to share our latest work published in mBio showing that Strepto can use glucose from any plant heteroside thanks to a unique 'swiss army knife' enzyme! DOI: 10.1128/mbio.00935-22
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New voracious enzyme from Strepto: Structure and function of BcpE2, the most promiscuous GH3-family beta-glucosidase for scavenging glucose from heterosides biorxiv.org/content/10.1101/…

Structure and function of BcpE2, the most promiscuous GH3-family beta-glucosidase for scavenging...

Cellulose being the most abundant polysaccharide on earth, beta-glucosidases hydrolyzing cello-oligosaccharides are key enzymes to fuel glycolysis in microorganisms developing on plant material. In...

biorxiv.org
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Old Enzyme, New Role: The β-Glucosidase BglC of Streptomyces scabiei Interferes with the Plant Defense Mechanism by Hydrolyzing Scopolin mdpi.com/1417312 #mdpibiophysica via @MDPIOpenAccess

Old Enzyme, New Role: The β-Glucosidase BglC of Streptomyces scabiei Interferes with the Plant...

The beta-glucosidase BglC fulfills multiple functions in both primary metabolism and induction of pathogenicity of Streptomyces scabiei, the causative agent of common scab in root and tuber crops....

mdpi.com
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The virulome of Streptomyces scabiei in response to cello-oligosaccharide elicitors | Microbiology Society microbiologyresearch.org/con…

The virulome of Streptomyces scabiei in response to cello-oligosaccharide elicitors

microbiologyresearch.org
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Transcription awakening by a Genetic compensation phenomenon. pubmed.ncbi.nlm.nih.gov/3275…

Deletion of bglC triggers a genetic compensation response by awakening the expression of alternat...

In the plant pathogen Streptomyces scabies, the gene bglC encodes a GH1 family cellobiose beta-glucosidase that is both required for primary metabolism and for inducing virulence of the bacterium....

pubmed.ncbi.nlm.nih.gov
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On the Risks of Phylogeny-Based Strain Prioritization for Drug Discovery: Streptomyces lunaelactis as a Case Study mdpi.com/766056 via @MDPIOpenAccess
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My 50th publication is out today!! 😃 frontiersin.org/articles/10.…

Frontiers | Production of Prodiginines Is Part of a Programmed Cell Death Process in Streptomyces...

Actinobacteria are prolific producers of antitumor antibiotics with antiproliferative activity, but why these bacteria synthetize metabolites with this bioac...

frontiersin.org
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Complete Genome Sequence of Streptomyces lunaelactis MM109T, Isolated from Cave Moonmilk Deposits. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/2979…
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#mdpiantibiotics Isolation, Characterization, and Antibacterial Activity of Hard-to-Culture Actinobacteria from Cave Moonmilk Deposits mdpi.com/274880 @antibioticsmdpi

Isolation, Characterization, and Antibacterial Activity of Hard-to-Culture Actinobacteria from Cave...

Cave moonmilk deposits host an abundant and diverse actinobacterial population that has a great potential for producing novel natural bioactive compounds. In our previous attempt to isolate cultura...

mdpi.com
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#mdpiantibiotics High-Throughput Sequencing Analysis of the Actinobacterial Spatial Diversity in Moonmilk Deposits mdpi.com/274660 @antibioticsmdpi
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Prodiginine Production in Streptomyces coelicolor Correlates Temporally and Spatially to Programmed Cell Death disq.us/t/2y9d85c
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Cracking the Regulatory Code of Biosynthetic Gene Clusters as a Strategy for Natural Product Discovery out now! :-) authors.elsevier.com/sd/arti…
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Listen to Elio Schaechter commenting our work on Moonmilk Streptomyces. :-) TWiM #157: Back to the ancestor schaechter.asmblog.org/schae…
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