Autoimmunity, Lupus, Germinal Center B cells, Memory B cells, BCR signaling, Infectious Diseases
Joined August 2017
- Tweets 105
- Following 165
- Followers 1,077
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11 Photos and videos
Mark Shlomchik Lab retweeted
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Mark Shlomchik Lab retweeted
@ShlomchikLab and his team have solved a 20-year #lupus mystery! In a new @jclinicalinvest paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR
ALT Eight microscopy images of B cell endosomes, which appear as colorful spheres, showing that chimeric TLR receptors made of TLR7 recognition elements with TLR9 signaling domains are localized in endosomes.
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22 Jul 2024
Check out the N&V in @NatImmunol by Inaki Sanz about
@elsner_rebecca's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg.
nature.com/articles/s41590-0…
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22 Jul 2024
We are excited about new questions raised by these studies, discussed in Inaki Sanz’s N&V rdcu.be/dOzOT. EF responses are prominent in autoimmune diseases including SLE, and infection-associated immunopathogenesis including COVID-19.
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22 Jul 2024
There is still much to learn! Is there a role for IL-12 in severe infection? Is there interplay with innate immunity? How is this response negatively regulated? How can it be shut off when it causes too much damage? Does IL-12 influence B cell memory?
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12 Jun 2024
Congrats to lead author @elsner_rebecca, along with Shuchi Smita and @MShlomchik on their newest study, recently published in Nature Immunology!
11 Jun 2024
Shlomchik and colleagues find that IL-12 initiates a B cell-intrinsic feed-forward loop between IL-12 and IFNγ which promotes B cell proliferation and plasmablast differentiation. Read it here: rdcu.be/dKvqK
nature.com/articles/s41590-0…
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24 Feb 2023
In our latest @JExpMed study, we characterized age-associated B cells (ABCs) in a model of lupus. We found unexpected heterogeneity among ABC subpopulations, identified precursor-product relationships, and showed that reducing ABCs improved renal disease. A 🧵! (1/12)
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24 Feb 2023
Altogether this suggested that ABC undergo frequent cycles of reactivation, with some ABC progeny retaining the ABC phenotype but others terminally differentiating to PB. (11/12)
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24 Feb 2023
We conclude that ABC are a diverse and dynamic population of B cells that promote autoimmune disease. Developing approaches to target ABCs specifically, rather than all B cells, could be beneficial in lupus. (12/12)
x.com/JExpMed/status/1629193…
24 Feb 2023
.@KMNickerson, @mshlomchik @Shlomchiklab @PittTweet & colleagues show that age-associated B cells are heterogeneous with respect to expression of memory and plasmablast markers. bit.ly/3ZgTxTw
#Autoimmunity
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