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ShorterLab @ShorterLab

Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn

Joined January 2012
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ShorterLab@ShorterLab
May 7
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/scie…

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how...

science.org
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From The Blue Bridge
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London, England 🏴󠁧󠁢󠁥󠁮󠁧󠁿
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London, England 🏴󠁧󠁢󠁥󠁮󠁧󠁿
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Life is nothing but an electron looking for a place to rest. — Albert Szent-Györgyi
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Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell cell.com/cell/fulltext/S0092…

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and...

Cancer-associated somatic variants are enriched in the brain immune cells of Alzheimer’s disease (AD) patients, driving them toward inflammation and proliferation, which may contribute to neuroinfl...

cell.com
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Survey of the human proteostasis network: the ubiquitin-proteasome system biorxiv.org/content/10.64898…

Survey of the human proteostasis network: the ubiquitin-proteasome system

Modification by ubiquitination governs the half-lives of thousands of proteins that are fated for elimination by either the proteasome or autophagy pathways, depending on the intricate architectures...

biorxiv.org
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Generalizable Prediction of Alzheimer Disease Pathologies with a Scalable Annotation Tool and an High-Accuracy Model medrxiv.org/content/10.1101/…

Generalizable Prediction of Alzheimer Disease Pathologies with a Scalable Annotation Tool and an...

Characterizing the cardinal neuropathologies in Alzheimer disease (AD) can be laborious, time consuming, and susceptible to intra- and inter-observer variability. The lack of high throughput unbiased...

medrxiv.org
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Day 5, Cell Biology of the Neuron #GRC
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RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons jneurosci.org/content/44/15/…

RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in...

DYT1 dystonia is a debilitating neurological movement disorder, and it represents the most frequent and severe form of hereditary primary dystonia. There is currently no cure for this disease due to...

jneurosci.org
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Identifying and targeting abnormal mitochondrial localization associated with psychoses biorxiv.org/content/10.1101/…

Identifying and targeting abnormal mitochondrial localization associated with psychoses

Therapeutics working by novel mechanisms are needed for patients with psychiatric conditions. Cell-based assays to identify candidates that reverse observed abnormalities could accelerate the...

biorxiv.org
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From development to regeneration: The spiny mouse as a model in neurob… sciencedirect.com/science/ar…
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