Peter Simmonds runs a research group in University of Oxford. Very interested in the broader evolution of viruses and constraints under which they are placed.
Joined June 2017
- Tweets 107
- Following 67
- Followers 843
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21 Photos and videos
23 Jun 2024
Here is my re-visiting of the C->U hypermutation phenomenon in SARS-CoV-2 genome 4 years from the start of the COVID pandemic:
tinyurl.com/mw3ezp6c
A trajectory of loss of C's / gain of U's, but weak 5' context effect and RNA structure dependence on edited sites. APOBEC 3A??
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Peter Simmonds retweeted
9 May 2023
Before #COVID19, when was the last #coronavirus #pandemic? Some have argued for 1889-1892 for the zoonosis of human #OC43 from bovine coronavirus, but in our new paper: journals.plos.org/plosone/ar…, we suggest 1899-1900, based on a review and replication of existing molecular data.
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Peter Simmonds retweeted
8 Apr 2023
Have you ever wondered how nucleic acid editing pathways (APOBEC, ADAR, and epitranscriptomics) might impact the adaptation of zoonotic viruses to humans? Of course you have! Lucky for you, we have a new review in COVIRO considering just that issue: authors.elsevier.com/c/1gtX3…
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Peter Simmonds retweeted
24 Mar 2023
The largest study to date on the viruses residing within our tissues
Unmasking the tissue-resident eukaryotic DNA virome in humans academic.oup.com/nar/advance…
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16 Feb 2023
Four principles to establish a universal virus taxonomy
journals.plos.org/plosbiolog…
It was a wonderful experience to share a workshop with world experts on virus diversity, genomics and classification.
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16 Feb 2023
These principles traverse a range of seemingly intractable points of disagreement and contention that have bedevilled virus classification since its inception in the 1960s. Resolution of these conflicts provides a clear strategy for harnessing the genomics revolution in virology
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16 Feb 2023
We believe these principles can be used to create a coherent and logical organisational structure for virus taxonomy that can incorporate the vast diversity of viruses that exist in the world.
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Peter Simmonds retweeted
25 Nov 2021
Come and work with some fantastic people (Oxford/UCL) on using genomics to improve safety of transfusion and transplantation: jobs.ac.uk/job/CKU178/projec…
jobs.ac.uk/job/CKV942/post-d…
Fully funded Oxford PhDs:
ndm.ox.ac.uk/study/dphil-the…
Fully funded UCL PhD:
jobs.ac.uk/job/CKJ558/phd-st…
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25 Nov 2021
We will be starting a major project to apply genomics to blood and transplant donor microbiology screening. We have project manager, post-doctoral and several funded PhD positions in Oxford and UCL - Apr/22. Great collaborative work with NHSBT:
Links to follow
Please RT!
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25 Nov 2021
Links for the posts:
In Oxford:
tinyurl.com/6tvz4r8c
tinyurl.com/5b2dvpnh
in UCL:
tinyurl.com/hf2xh6d8
and the PhDs for Oxford:
tinyurl.com/kh822v9v
and UCL:
tinyurl.com/39u2wkpr
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25 Nov 2021
Project background:
Genomic Revolutions in Donation Screening and Safety (GRiDDS) is funded NIHR for 5 years and providing resources for a major expansion of genomics-based technologies in blood and transplant donation screening and emerging virus / pandemic preparedness .
Peter Simmonds retweeted
11 Nov 2021
Fantastic thread - we report here a total of 139 EV-D68 cases from Europe, most of them in September and numbers are likely to increase. A timely reminder that you will only find what you are looking for!
11 Nov 2021
1. Europe is seeing an upswing in cases of an infection that has been linked to a polio-like phenomenon called #AFM — acute flaccid myelitis — according to a report today in @Eurosurveillanc. Enterovirus D68 is thought to trigger AFM in some kids. eurosurveillance.org/content…
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Peter Simmonds retweeted
11 Nov 2021
Are you ready and looking for it! Did you know EV-D68 is back?
Thankful for the great collaboration! @ENPEN_ESCV @KimBenschop
@TheaKFischer @Simmonds_Lab
@ESCVirology @Eurosurveillanc
eurosurveillance.org/content…
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23 Jun 2021
Disaster - are we going back to square 1? Despite the vaccine coverage
22 Jun 2021
Very nice article comprehensively reviewing aspects of compositional bias in RNA viruses & interrelationships with still poorly characterised cellular mechanisms responding to RNA sequence motifs - ZAP, APOBECs, ADAR & many more, and selection biases from effects on translation
22 Jun 2021
1/2 Our review article about genome composition biases in RNA viruses is now online: onlinelibrary.wiley.com/doi/….
TL:DR (it is long): 1. Composition biases occur at mono- and di- nucleotide level and beyond, at amino acid level and codon pairs.
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Peter Simmonds retweeted
16 Jun 2021
Our review of the ZAP antiviral pathway and how it specifically targets viruses is out in @AnnualReviews. Thank you to @stuartjdneil & @Swanson_Chad. annualreviews.org/doi/abs/10…
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Peter Simmonds retweeted
16 Jun 2021
See you there!
16 Jun 2021
The #ESCV2021 Conference is coming to you!
Wherever you are, we can learn together, reshaping our community and raising standards of #ClinicalVirology. More of what you can expect from the #ESCV2021 programme below : ow.ly/L6g450FbmyH
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2 Jun 2021
Very experimental but also very surprising, here is some evidence for excess C->U changes in a range of mammalian RNA viruses, potentially related to the much discussed phenomenon in SARS-CoV-2:
doi.org/10.1371/journal.ppat…
Consequences for virus evolution: interesting.....
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30 May 2021
As some may know, Finnish doesn't have separate b's and p's, so new words may be a bit of a guess - usually right but not always!
30 May 2021
Holiday week has started - trying out our new baddleboard and canoe in the Thames. Beautiful day!
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