STEM CELLS TRANSLATIONAL MEDICINE is focused on speeding translations of emerging lab discoveries into legitimate clinical trials and bedside application.
Joined January 2011
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Moderate neuroprotection of combination cell therapy in fetal growth restricted newborns at postnatal day 10
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A selection model for umbilical cord blood units with high isolation yield of total nucleated and CD34 cells
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This study presents findings on METTL1 modified human umbilical cord MSCs, emphasizing therapeutic effect and mechanisms involved in treating metabolic dysfunction-associated steatotic liver disease.
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Bone marrow MSC treatment improved glucose metabolism in specific functional brain regions of aged macaques in this study using 18F-FDG PET/CT imaging with texture analysis and SPM8.0.
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A report on potential cell-based therapies to treat premature ovarian insufficiency after chemotherapy: doi.org/10.1093/stcltm/szag0…
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This article reports a procedure using caprolactam-based polymer as a cost-effective alternative to human serum albumin for generating functional HSPCs across diverse PSC lines and culture conditions, paving the way for a more consistent production.
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Randomized trial on patients with advanced knee osteoarthritis treated with allogeneic expanded adipose-derived MSCs. Results showed the ability of this treatment to mitigate symptoms & improve joint function for several years without serious side effects.
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This study explored the fate of transplanted donor limbal cells after corneal surface reconstruction in a mouse model and found evidence that both the transplanted stem cells and the endogenous residual stem cells contribute to tissue regeneration.
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This study examines the clinical outcomes and immune reconstitution dynamics in patients with severe aplastic anemia exhibiting mixed chimerism compared with those with full donor chimerism following HLA-matched hematopoietic stem cell transplantation.
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This study explores the mechanism by which MSC-derived small extracellular vesicles alleviate airway inflammation by influencing dendritic cells.
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This concise review addresses the global regulatory landscape of stem cell medical aesthetics, highlighting significant differences in the regulatory frameworks of the United States, Europe, Japan, South Korea, and China.
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Autologous stem cell transplantation may provide a therapeutic option for pediatric patients with treatment-resistant juvenile systemic sclerosis, offering durable clinical benefit and improved quality of life.
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Perspective on the efficiency of carcinogenesis and the potential of dynamic precision medicine to prolong survival and increase cure rate.
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Commonly used study designs for hiPSC-based disease modeling, drug response, or cardiac toxicity are compared in terms of applicability for different research questions, statistical analysis, and attainable power.
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Cell therapy for stroke and spinal cord injury in clinical trials
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This review discusses the mechanisms and therapeutic applications of epicardial activation, emphasizing its potential in cardiac regenerative medicine.
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Meta-analysis evaluating the efficacy and mechanisms of stem cell therapy in rodent models of hepatic ischemia-reperfusion injury
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A challenge in regenerative medicine is finding ways to restore the body’s natural capacity for repair. This study reports on a powerful molecular tool, the miR-302/367 cluster, which plays an important role in reversing signs of aging.
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This review discusses cellular senescence and functional tissue decline, focusing on small molecule-driven reprogramming as a tool to rejuvenate aged cells and tissues.
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This concise review discusses the most recent scientific progress in the field of human iPSC-derived neural stem/progenitor cell therapy for spinal cord injury.
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