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Structure @Structure_CP

Structure is a monthly publication of @CellPressNews dedicated to research at the cutting edge of #structuralbiology. Tweets are by the Editors.

Joined August 2012
  • Tweets 8,514
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Online now! An extracellular allosteric gate modulates the ligand efficacy of GPR119 dlvr.it/TSz7MY

An extracellular allosteric gate modulates the ligand efficacy of GPR119

Zhang et al. report a cryo-EM structure of GPR119 bound to a partial agonist, revealing that ligand-induced closure of an extracellular gate restricts receptor activation. This study uncovers a...

cell.com
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Online now! Molecular basis for the dopamine reuptake and inhibition mechanism of human dopamine transporter dlvr.it/TSxXxn

Molecular basis for the dopamine reuptake and inhibition mechanism of human dopamine transporter

Yin et al. report cryo-EM structures of the human dopamine transporter, revealing how it captures dopamine and how antidepressants block its activity. Their findings explain drug selectivity and...

cell.com
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Cross-linking with diazirines: Bright sides and blind spots dlvr.it/TSxRBS

Cross-linking with diazirines: Bright sides and blind spots

Cross-linking mass spectrometry (XL-MS) has become an important method in integrative structural biology. Diazirine-based cross-linkers are widely used, but instead of being unselective, they...

cell.com
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Meet the author: Junyu Xiao dlvr.it/TSxLX2

Meet the author: Junyu Xiao

In this meet-the-author Q&A, Structure editor-in-chief Karin Kühnel speaks to our advisory board member Junyu Xiao from Peking University about his research group’s recent Structure paper entitled...

cell.com
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A structural glimpse into lipid phosphate dephosphorylation by human LPP2 dlvr.it/TSxCWv
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Tracking the redox reaction of the iron enzyme ribonucleotide reductase using continuous SerialED and SFX dlvr.it/TSx2GR

Tracking the redox reaction of the iron enzyme ribonucleotide reductase using continuous SerialED...

Pacoste and Kumar et al. use continuous serial electron diffraction (c-SerialED) and SFX to determine the structures of a metalloenzyme across multiple redox states. Close agreement between c-Seria...

cell.com
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Join speaker Martin Beck @MPIbp at #CS3Dbiologicalfunction2026. Martin’s cutting-edge research combines cryo-ET, structural proteomics and computational modeling to uncover how molecular machines function within cells. Abstract deadline: July 3, 2026 hubs.li/Q04ksd4_0
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Structure of the IgY-FcRY complex and its comparison with IgG-FcRn dlvr.it/TSvM8w

Structure of the IgY-FcRY complex and its comparison with IgG-FcRn

Deng et al. reveal how the chicken yolk sac receptor FcRY recognizes IgY, the bird antibody passed from mother to embryo. The structure identifies key contact sites and suggests that FcRY and FcRn,...

cell.com
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Cryo-EM structures of prevalent gut phage PD491P1 uncover extensive disulfide stabilization and distinct structural adaptations dlvr.it/TSvFcc

Cryo-EM structures of prevalent gut phage PD491P1 uncover extensive disulfide stabilization and...

Cai et al. report cryo-EM structures of the abundant gut phage PD491P1, defining its capsid, head-to-tail, and tail tip architecture. An extensive disulfide network, distinctive portal interfaces,...

cell.com
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Cryo-EM structure of human lipid phosphate phosphatase 2 dlvr.it/TSv94F

Cryo-EM structure of human lipid phosphate phosphatase 2

Wang et al. determined the cryo-EM structure of hLPP2, revealing a tetrameric assembly and a conserved PAP2 family reaction mechanism. Bound phosphatidylcholine shows how phosphatidic acid enters the...

cell.com
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Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction dlvr.it/TSv1xY

Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction

The TACC3-CHC complex stabilizes mitotic spindle k-fibers. Gunning et al. uncovered the structural mechanism by which TACC3 phosphorylation enhances the interaction with CHC. They developed a...

cell.com
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Classifying biophysical subpopulations of insulin secretory granules using quantitative whole-cell structure analysis dlvr.it/TSts4J

Classifying biophysical subpopulations of insulin secretory granules using quantitative whole-cell...

Chang et al. combine quantitative whole-cell imaging and unsupervised clustering to define insulin granule subpopulations in pancreatic beta cells. They show that secretory stimuli remodel the...

cell.com
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Cryo-ET reveals distinct Gag lattice architectures in virus-like particles and immature HIV-1 dlvr.it/TStPfQ

Cryo-ET reveals distinct Gag lattice architectures in virus-like particles and immature HIV-1

Preece et al. compare Gag lattice characteristics between HIV Gag virus-like particles and immature virions, highlighting variation in Gag copy number and correlation with lattice curvature. These...

cell.com
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CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1 dlvr.it/TStHy6

CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical effici...

Wang et al. show that two related regulatory proteins, CAND1 and CAND2, promote CUL4-mediated protein degradation and support dynamic exchange of most CUL4 substrate receptors with largely comparable...

cell.com
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prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation dlvr.it/TStCQp

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation

He et al. show that label-free deep learning can be applied to cryo-EM micrographs and power spectra to elucidate image quality and achieve 3D reconstructions comparable to manually curated datasets....

cell.com
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From birds to man—Divergence and convergence in the co-evolution of an antibody/receptor complex dlvr.it/TSt4C6
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Online now! Structural insights into allosteric regulation of GdpP: A conformationally dynamic phosphodiesterase dlvr.it/TSs4yx

Structural insights into allosteric regulation of GdpP: A conformationally dynamic phosphodiesterase

Shataer et al. present cryo-EM structures of the Streptococcus mutans phosphodiesterase GdpP, revealing a tetrameric architecture in which a repurposed GGDEF domain scaffolds the catalytic domains....

cell.com
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Online now! Structural basis for proton inhibition of the two-pore domain K channel TASK-1 dlvr.it/TSr4T0

Structural basis for proton inhibition of the two-pore domain K channel TASK-1

Docter et al. show how acidic extracellular conditions close the TASK-1 potassium channel. Low pH triggers structural changes that create a hydrophobic seal to block ion flow. Disease-linked mutati...

cell.com
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Join Martin Beck @MPIbp at #CS3Dbiologicalfunction2026. Martin’s cutting-edge research combines cryo-ET, structural proteomics, and computational modeling to uncover how molecular machines function within cells. Abstract deadline: July 3, 2026 hubs.li/Q04jLvQW0
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We welcome M. Madan Babu @StJude to #CS3Dbiologicalfunction2026. Madan’s research on biomolecular regulation, protein interactions & cellular organization continues to shape our understanding of complex biological systems. Abstract deadline: July 3, 2026 hubs.li/Q04h_-1N0
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