Ecstatic to announce Merge Labs! 🧠🚀 I’m honored to work alongside my co-founders—Tyson Aflalo, @mikhailshapiro, @sandroherbig, @alexblania, and @sama on bridging biological and artificial intelligence. They’re *the* team to take on a mission this ambitious. We’re grateful to have partners like @OpenAI who share a long-term view on what it takes to build foundational technology. If you want to work on hard, foundational neurotech problems, come build with us.

Invasive / non-invasive BCI is often misleading. Consider more precise terms: Implanted. Wearable. Replaceable. Upgradeable. Risk (with quantification). Therapeutic. Consumer. Etc.

Congrats to two of my closest/longtime friends Han and @kvnbnntt and new friends like @af_gao on launching @fearn_ai! A Promethean effort to give inventors the power! 💪 Proud to be a tiny part of their story. Go team!

Neuropixels Opto is out! 🎉🥳🍾🚨 Congratulations to a fantastic team! nature.com/articles/s41592-0…

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

Building AI resilience is among the most important work of our generation. We have a lot to do to get it right. At the OpenAI Foundation, this is where we’re starting:

New FRO dropping!

AI will transform the economy and jobs, creating opportunities while also bringing new challenges. At OpenAI Foundation, we are launching a program to better understand shifts, support the transition, and build long-term economic security. Starting with $250M dedicated openaifoundation.org/news/ec…

One of the most important areas of AI Safety and @hannu is just the absolute best at what he does (which includes many things!)

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It's happening! 🚀🚀🚀

NSF announces $1.5B NSF X-Labs initiative to pursue generational breakthrough science efforts. NSF X-Labs will scale a new generation of transformative independent research organizations to advance breakthrough science outside of traditional institutions. nsf.gov/news/nsf-announces-1…

venice was built on a sandbar in 421 ad what's stopping us?

I am very proud of the progress that @RenPhilanthropy and its partners have made in our first two years – $533 million in funding for science and technology, launching more than 20 programs, training 45 scientists and innovators to design transformative, ARPA-style programs, partnering with the UK, German and Japanese governments, and publishing our first 10 playbooks on the “how” of innovation. Our field strategists are accelerating progress in areas such as AI for fundamental math, AI for early literacy, geologic hydrogen, stabilizing the Arctic climate, low-cost space telescopes, and open-source software for life sciences. Thanks to all the philanthropists, foundations, and governments that have supported our work – and please reach out if you’d like to collaborate. The best is yet to come!

If you had 10x the agency you feel you have now, what would you do?

Once in a while, science expands human capabilities. This is one such case. Super cool. "Oz enables display of colors that lie beyond the well- known, bounded color gamut of natural human vision" "Subjects report that olo in our proto- type system appears blue-green of unprecedented saturation" science.org/doi/10.1126/scia…

.@AdamMarblestone thinks it might cost ~low billions to map the human brain connectome. The benefit is getting answers about the brain’s secret sauce: esp. why are humans so much more sample- and energy-efficient. If labs are going to be spending trillions of dollars on compute by the end of the decade, Adam's pitch is: give him 1/100th of that to actually figure out these big questions about intelligence.

We're on the precipice of massive sociotechnical transformation. In thinking about what root-level technologies will matter most, I keep coming back to two themes. The first is Coordination. Non-linear and asymmetric technology acceleration is going to push things way out of equilibrium over the next couple of decades. We'll need counterforces that hold and pull society together. New technologies, institutions, and movements that can: - amplify trust, connection and collaboration. - drive collective flourishing while preserving individuality. - get us closer to the pareto frontier of shareholder and social value creation. The second is Neurotechnology. Neurological disorders are humanity's biggest barrier to productivity, agency, happiness, and peace. Meanwhile, powerful AI is about to challenge the very foundations of human identity and experience. Applying frontier engineering and invention to frontier neuroscience, I think we can massively shift the trajectory of human flourishing: - understand what makes us “us.” - gain control over psychiatric disorders, learning, cognition, and bias. - solve alignment and symbiosis with hyperintelligent machines. - protect, enhance & preserve the human experience. Thrilled to explore these topics as part of @RenPhilanthropy's growing community of scientists, funders, and entrepreneurs working to slingshot humanity into a better future!

Every drug × every target 📊 228 targets 💊 1,397 FDA-approved compounds 🔬 558K interactions @EvEBiotech's largest data release ever adds 29 new GPCRs in the Gs pathway 1 kinase (PDGFRa-D842V) All on @huggingface 🤗

Sure, there's a lot of slop. But my backlog of quality content from brilliant people that I've gotten to know and trust (either in their artifacts or IRL) has never been larger. So much incredible progress being made right now.